- Was in a car crash at age 4 that killed her 34 year old mother, her 3 year old sister, and a 25 year old cousin. She has used that as a motivation for her life.
- Appeared in Sheryl Crow's 1997 video "A Change Would Do You Good".
- Graduated from NYU in 1987.
- Best friends with Heather Graham.
- Mother of Stella Chesnut and Nolan Chestnut.
- Wore an off-white "garden dress" designed by SNL wardrobe department head Dale Richards in her May 2004 wedding to Fritz Chestnut.
- She studied drama at HB Studio in Greenwich Village in New York City.
- Had a second baby, a boy, named Nolan Shannon Chestnut. (March 15, 2005)
- Molly's dad Jim was the youngest of 10 siblings.
- Mother was a librarian.
- Molly & Fritz welcomed their first child, a girl named Stella Shannon Chestnut. (September 28, 2003)
- She is from the same city in Ohio as Paul Newman, Fred Willard and David Wain. Shaker Heights, Ohio is also the name of the place that the Cleaver family was from in the early sitcom, "Leave It To Beaver".
- Both of her parents were of Irish descent. Her maternal grandparents were born in Achill, Mayo, Ireland, with her grandfather being from Cloghmore and her grandmother from Ballinglanna.
- Presented at the 2000 GLAAD Media Awards for films and TV shows that accurately portray gay and lesbian characters.
- Became engaged to Fritz Chestnut, an artist. (March 2003)
- BFA in Drama - New York University, Tisch School of the Arts (1987).
- Has been buddies since the 5th grade with George Cheeks, CEO of CBS Entertainment Group. They appeared in a theater production of The Wizard Of Oz.
- Graduated from Hawken School in Chesterland, Ohio, June 1983, where she was a classmate of actress Greer Goodman.
- In 2022, she was the celebrity spokeswoman for Lending Tree.
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