- Tied with Nicholas Courtney for the record of appearing with 7 on-screen incarnations of the Doctor. Although she is best known as a companion with Jon Pertwee and Tom Baker, she appeared with all of the first five Doctors in The Five Doctors (1983). She later appeared with David Tennant and Matt Smith's Doctors in Doctor Who (2005) and The Sarah Jane Adventures (2007).
- In 2021, her daughter, Sadie Miller, took over as her character Sarah Jane Smith in Doctor Who audio productions by Big Finish.
- Returned to playing her Sarah Jane Smith character from the original Doctor Who (1963) series (1963-1989) in the new in School Reunion (2006), The Stolen Earth (2008), Journey's End (2008), The End of Time: Part Two (2010), and her own spin-off series, The Sarah Jane Adventures (2007).
- Along with David Tennant, John Leeson, Tommy Knight, Alexander Armstrong, Lachele Carl, and Matt Smith, she is one of seven actors to play the same character (Sarah Jane Smith) in both Doctor Who (2005) and The Sarah Jane Adventures (2007).
- Voted best guest actress by readers of Doctor Who magazine for School Reunion.
- Her wedding reception took place at Penny Lane in her home city of Liverpool, the street which was famously immortalised in the song by The Beatles.
- Returned to playing the role of her Doctor Who (1963) companion character, intrepid journalist "Sarah Jane Smith", in a series of brand new, original self-contained audio adventures on single CD in 2002 and again in 2006.
- Along with John Leeson, Nicholas Courtney, and Katy Manning, she is one of four actors to play the same character (Sarah Jane Smith) in both Doctor Who (1963) and The Sarah Jane Adventures (2007).
- She starred in K-9 and Company: A Girl's Best Friend (1981), the first television spin-off of Doctor Who (1963), which featured Sarah Jane Smith as played by Sladen, and K-9 as voiced by John Leeson.
- One of over 30 performers to have acted in both 20th century Doctor Who (1963) and the 21st century Doctor Who (2005) TV series.
- Along with Peter Davison and John Leeson, she is one of only three actors to play the same character (Sarah Jane Smith) in both Doctor Who (1963) and Doctor Who (2005).
- She is the mother of Sadie Miller.
- Along with John Leeson, she is one of only two actors to play the same character (Sarah Jane Smith) in four different television productions based in the "Doctor Who" universe: Doctor Who (1963), K-9 and Company: A Girl's Best Friend (1981), Doctor Who (2005) and The Sarah Jane Adventures (2007). She appeared with Leeson's character in all four.
- The character of Clara Oswald in Doctor Who (2005) was named after her.
- Thanks to her presentation job on The Fuel Fishers (1977), was the first woman to set foot on a North Sea oil rig, the Dundee Kingsnorth.
- Had to deliver daughter Sadie Miller via emergency Caesarean section after the baby went into distress during labor.
- She was offered the roles of Ellen Donaldson and The Space Girl in Lifeforce (1985).
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