- His broad spectrum of character voices, noises and other vocal effects that have appeared over the last 40 years in motion pictures, have vaulted him to number one on the "All Time Top 100 Stars at the Box office" list. The revenue of films he has participated in have generated over 12 billion dollars worldwide. His work in over 90 films has put him ahead of Eddie Murphy, Harrison Ford, Tom Hanks and Samuel L. Jackson.
- Has done every voicing of Fred Jones for all of the Scooby-Doo animated series with the sole exception of A Pup Named Scooby-Doo (1988). Even in parodies and cameos on different television series, he has always done this voice.
- Has played the same character (Fred Jones) on 14 different series: Scooby Doo, Where Are You! (1969), The New Scooby-Doo Movies (1972), The Scooby-Doo/Dynomutt Hour (1976), Dynomutt Dog Wonder (1976), Scooby-Doo and Scrappy-Doo (1979), The Scooby and Scrappy-Doo Puppy Hour (1982), The New Scooby-Doo Mysteries (1984), Scooby's Mystery Funhouse (1982), Family Guy (1999), Harvey Birdman, Attorney at Law (2000), What's New, Scooby-Doo? (2002), Robot Chicken (2001), Batman: The Brave and the Bold (2008) and Scooby-Doo! Mystery Incorporated (2010).
- Referred to in Hollywood as a voice god.
- Has worked with Robin Williams in five films: A Wish for Wings That Work (1991), Aladdin (1992), In Search of Dr. Seuss (1994), Jumanji (1995) and Aladdin and the King of Thieves (1996).
- One of the most prolific voice actors of all time, he has been involved with some of the most popular and important animated series of all time as well, beginning with his role as level-headed leader Fred Jones on "Scooby-Doo", the evil Decepticon leader Megatron on The Transformers (1984) (among others), Dr. Ray Stantz on The Real Ghostbusters (1986), and a variety of supporting roles on G.I. Joe (1985), Tiny Toon Adventures (1990), Animaniacs (1993) and The Smurfs (1981).
- Became the sixth actor to appear in two films to gross $1 billion with Alice in Wonderland (2010) and Transformers: Dark of the Moon (2011). He is the first voice actor to achieve this feat.
- Has provided voices for eight of the original 14 Decepticons on The Transformers (1984) animated series: Megatron, Soundwave, Skywarp, Laserbeak, Rumble, Frenzy, Ravage and Buzzsaw. He voiced two of the original Autobots as well: Trailbreaker and Mirage, as well as one of the Dinobots (Sludge) that also appeared in the first season.
- He also did the animal voice effects including Dumbo in Who Framed Roger Rabbit (1988).
- Having been the voice of Spock's screams, he is one of three Star Trek cast members who has also provided a voice for Star Wars. The others include George Takei and Simon Pegg.
- His "Doctor Claw" voice came about as a result of him trying to do an impression of singer-songwriter Barry White.
- Has shared two roles with Leonard Nimoy. When the third season of The Transformers (1984) came around, Frank took the role of Galvatron that Leonard Nimoy had taken in The Transformers: The Movie (1986). And in Star Trek III: The Search for Spock (1984), Frank provided the screams of Leonard Nimoy's most famous character Spock.
- His "Doctor Claw" voice is arguably his most famous role. Aside from playing Doctor Claw on Inspector Gadget (1983), he has used the voice for other characters, such as Darkseid on Super Friends (1973), Emperor Krulos on Dino-Riders (1988), Soundwave on The Transformers (1984) (only heavily modified with a vocoder, to give it a distinct monotone, robotic sound), as well as in movies such as the Cave of Wonders in Aladdin (1992), Shao Kahn in Mortal Kombat (1995), Soundwave again in both Transformers: Revenge of the Fallen (2009) and Transformers: Dark of the Moon (2011) (without the vocoder effects), as well as playing the Devil in four movies: The Golden Child (1986), All Dogs Go to Heaven (1989), Bill & Ted's Bogus Journey (1991) and Spawn (1997).
- Has done voices for both the Star Trek movie series and Star Trek: Voyager (1995).
- Although he never met with the producers or the director Michael Bay, Bay felt his Welker's G1 Megatron voice did not fit the film and Bay's new interpretation. Ironically, he recreated the G1 voice for Transformers: The Game (2007) based on the movie, and was once again reunited with his old nemesis Optimus Prime played by Peter Cullen.
- Has worked with Leonard Nimoy in four films: Star Trek III: The Search for Spock (1984), The Transformers: The Movie (1986), The Pagemaster (1994) and Transformers: Dark of the Moon (2011).
- In Tiny Toon Adventures (1990), he voiced Furrball, Gogo Dodo, Calamity Coyote, Little Beeper, Byron Basset, Uncle Stinky Pig, Henry Bear and Ralph the Guard who later appeared in Animaniacs (1993), where Frank not only voiced Ralph, but also voiced Thaddeus Plotz, Buttons, Runt, Flavio Hippo and Chicken Boo.
- Has appeared in six films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Indiana Jones and the Raiders of the Lost Ark (1981), Who Framed Roger Rabbit (1988), The Little Mermaid (1989), Beauty and the Beast (1991), The Lion King (1994) and Shrek (2001).
- Has two roles in common with Carl Steven: (1) Welker provided Spock's screams in Star Trek III: The Search for Spock (1984) while Steven played the nine-year-old version of the character in the same film and (2) Welker voiced Fred Jones in Scooby Doo, Where Are You! (1969) and its various spin-offs while Steven voiced him in A Pup Named Scooby-Doo (1988).
- Attended Santa Monica City College where he majored in Theatrical Arts.
- Based the voice of the Cave of Wonders in Aladdin (1992) on Sir Sean Connery.
- Born on the exact same date as singer/actress Liza Minnelli.
- He voiced Grimace in many McDonald's television commercials from 1986 to 2003 as well as the 1995 Halloween-themed Kid Rhino cassette tapes "Ronald Makes It Magic", "Travel Tunes", "Silly Sing Along" and "Scary Sound Effects".
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