- Because he was only 17 at the time of filming Superbad (2007), his mother was required to be on set during the filming of his sex scene.
- Great-grandson of producer Charles Mintz and M.J. Winkler (born Margaret Winkler), who was a prominent figure in the early history of animation films in Hollywood. Great-great-nephew of M.J.'s brother, animation producer George Winkler.
- Attended El Camino Real High School from 2003 to 2007.
- Anchorman: The Legend of Ron Burgundy (2004) is one of Christopher's favorite comedies.
- Christopher's father is from a Catholic family, of half Polish, three eighths French-Canadian, and one eighth Irish, descent. Christopher's mother is from a Jewish family (from Austria, Hungary, Russia, Germany, and Poland). Through his mother, Christopher is a second cousin, three times removed, of politician Barry Goldwater, who was the Republican nominee for President in 1964. Christopher's maternal great-great-great-great-grandparents, Hirsch Goldwasser and Scheindel-Chawe/Fravda, were also Barry Goldwater's paternal great-grandparents.
- Member of the same Los Angeles gym as Ryan Gosling, Bradley Cooper, Jodie Foster, Michelle Monaghan, Jason Sarayba, and Ashley Tisdale.
- Member of the Sunday Men's Basketball League.
- On December 24, 2022, Mintz-Plasse announced his engagement Britt Bowman after 5 years of dating.
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