- Midfielder for Envigado F.C. (2006-07), C.A. Banfield (2008-10), F.C. Porto (2010-13), A.S. Monaco F.C. (2013-14), Real Madrid (2014-17, 2019-20), Bayern München (2017-19) and Everton F.C. (2020-).
- Won the Primera B (2007) with Envigado; Primera División Argentina (2009) with C.A. Banfield; Primeira Liga (2011, 2012, 2013), Taca de Portugal (2011), Supertaca (2010, 2011, 2012) and UEFA Europa League (2011) with F.C. Porto; La Liga (2017), UEFA Champions League (2016, 2017), UEFA Super Cup (2014, 2016) and FIFA Club World Cup (2014, 2016) with Real Madrid; and the Bundesliga (2018) with Bayern München.
- International with Colombia National Football Team since 2011. Member of the Copa América 2015, 2016, 2019, and the Brazil '14 and Russia '18 squads.
- Met his wife Daniela Ospina at the age 17.
- Brother-in-law of David Ospina.
- Has 2 children: daughter, Salomé Rodríguez Ospina (b. May 29, 2013) with estranged wife, Daniela Ospina & son, Samuel Rodríguez De Lima (b. October 30, 2019) with girlfriend, Shannon De Lima.
- Top assist provider of the FIFA U20 World Cup (2011), Ligue 1 (2014) and Copa del Rey (2017).
- 2008: The youngest ever expatriate footballer to play in the Argentine Primera División with 17 age.
- Won the Portuguese Golden Ball in 2012.
- Named in the Team of the Season of the Ligue 1 (2014), La Liga (2015) and Bundesliga (2018).
- Golden Boot, All-Star Team, Dream Team and Goal of the Tournament at the 2014 FIFA World Cup.
- Won the FIFA Puskás Award in 2014.
- Named in the UEFA Team of the Year in 2015.
- New species of coral discovered by Santiago Herrera named "Paragorgia James" after him.
- Named in the UEFA Champions League Squad of the Season in 2018.
- In a relationship with Shannon De Lima since 2018.
- Named in the Copa América Team of the Tournament in 2019.
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