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- Using a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- Jack Skellington, king of Halloween Town, discovers Christmas Town, but his attempts to bring Christmas to his home causes confusion.
- When a young boy accidentally triggers the universe's most lethal hunters' return to Earth, only a ragtag crew of ex-soldiers and a disgruntled scientist can prevent the end of the human race.
- An industrialist invites some experts to visit his theme park of cloned dinosaurs. After a power failure, the creatures run loose, putting everyone's lives, including his grandchildren's, in danger.
- With Spider-Man's identity now revealed, Peter asks Doctor Strange for help. When a spell goes wrong, dangerous foes from other worlds start to appear.
- Young Blade Runner K's discovery of a long-buried secret leads him to track down former Blade Runner Rick Deckard, who's been missing for thirty years.
- Following clues to the origin of mankind, a team finds a structure on a distant moon, but they soon realize they are not alone.
- A young American studying in Paris in 1968 strikes up a friendship with a French brother and sister. Set against the background of the '68 Paris student riots.
- A blade runner must pursue and terminate four replicants who stole a ship in space and have returned to Earth to find their creator.
- After being bitten by a genetically-modified spider, a shy teenager gains spider-like abilities that he uses to fight injustice as a masked superhero and face a vengeful enemy.
- A half-vampire, half-mortal man becomes a protector of the mortal race, while slaying evil vampires.
- A father and son, both coroners, are pulled into a complex mystery while attempting to identify the cause of death of a young woman who was apparently harboring dark secrets.
- Security guard David Dunn uses his supernatural abilities to track Kevin Wendell Crumb, a disturbed man who has twenty-four personalities.
- A brilliant plastic surgeon, haunted by past tragedies, creates a type of synthetic skin that withstands any kind of damage. His guinea pig: a mysterious and volatile woman who holds the key to his obsession.
- Four teenagers are sucked into a magical video game, and the only way they can escape is to work together to finish the game.
- When strange seeds drift to earth from space, mysterious pods begin to grow and invade San Francisco, replicating the city's residents one body at a time.
- A biologist signs up for a dangerous, secret expedition in which the laws of nature don't apply.
- When a pilot crashes and tells of conflict in the outside world, Diana, an Amazonian warrior in training, leaves home to fight a war, discovering her full powers and true destiny.
- A team of scientists aboard the International Space Station discover a rapidly evolving life form that caused extinction on Mars and now threatens all life on Earth.
- A family man is drafted to fight in a future war where the fate of humanity relies on his ability to confront the past.
- The X-Men send Wolverine to the past in a desperate effort to change history and prevent an event that results in doom for both humans and mutants.
- Dr. Richard Kimble, unjustly accused of murdering his wife, must find the real killer while being the target of a nationwide manhunt led by a seasoned U.S. Marshal.
- At an Antarctica research site, the discovery of an alien craft leads to a confrontation between graduate student Kate Lloyd and scientist Dr. Sander Halvorson.
- A strange black entity from another world bonds with Peter Parker and causes inner turmoil as he contends with new villains, temptations, and revenge.
- Wonder Woman finds herself battling two opponents, Maxwell Lord, a shrewd entrepreneur, and Barbara Minerva, a friend-turned-foe. Meanwhile, she also ends up crossing paths with her love interest.