Captain Grey Holden's (Darren McGavin) riverboat was named "Enterprise".
Burt Reynolds left the show in the middle of the first season because of behind-the-scenes disputes with Darren McGavin. He was replaced by Noah Beery Jr.. when the second season began.
Scenes showing the riverboat Enterprise paddling down the Mississippi River were miniature sets filmed in Hollywood.
Chip's dog, Andy Jackson, never received any screen credits.
There are three episodes where Burt Reynolds character becomes the captain, replacing Darren McGavin, who, in the beginning of the episodes, leaves for a gambling trip to New Orleans. At the end of each episode, Burt's character Ben explains all the craziness that occurred... one episode dealing with a gorilla who mugs and robs people. McGavin's character would be dumbfounded at the nonchalant way these stories were told.