For the show's final season in 1965 - 66, the format was completely changed in order to capitalize on the popularity of spy shows like "The Man from U.N.C.L.E. (1964)," with Amos Burke himself becaming a secret agent. The title of the series was changed accordingly: "Amos Burke - Secret Agent." But the new format proved unpopular, and the show was cancelled.
"Burke's Law" originated from an episode of the anthology series "Who Killed Julie Greer? (1961)." Dick Powell played Inspector Burke on that episode.
Amos Burke became a slightly different character in this series from the fellow he had been in "Who Killed Julie Greer? (1961)," the opening episode of "The Dick Powell Theatre (1961)" from which "Burke's Law" was spun off. Dick Powell, who had originally played him, died a few months before "Burke's Law" began to air. Gene Barry, his replacement in the part, was some 15 years younger. The character became much suaver, with emphasis on his designer clothes, his upper-crust social status, and his playboy lifestyle. Also, Burke had now received a promotion in his police career, becoming a captain instead of an inspector.