I don't care that this movie is listed as a horror on IMDb or that the video cover art features hands coming from a wall to grab a woman or that the film is included on just about every budget horror set, Die Sister, Die! has little in the way of horror to offer. There are moments of horror to be sure, but it's really more of a drama/mystery. If you're a fan of Columbo/70s style mysteries, this movie might appeal to you.
My problems with the movie have nothing to do with the way it has been incorrectly categorized over the years. Instead, I see weaknesses in the script and acting. Too much of the movie is just plain dull. Die Sister, Die! might have been much more enjoyable with a tighter script and a shorter run time. There's just too much in the way of padding for my taste. As for the acting, Antoinette Bower is dreadful in the pivotal role of the nurse. She plays the role as a woman who appears on the verge of going comatose at any minute.
The plot is standard 70s made-for-TV stuff. An older woman wants to commit suicide because of some unknown guilt. Her brother, seeking to inherit the family's fortune, would like to see her succeed. He hires a nurse to look after his sister and to make sure the next suicide attempt is the last one. The family doctor plays detective and puts the pieces together. There are some fairly entertaining twists and turns along the way, all leading to a satisfactory, if not predictable, conclusion.
Fans of 70s Movie of the Week fare should definitely check this one out.