Saskia Wickham's real-life parents, Jeffry Wickham and Clare Stewart, played the adoptive parents of her character, Erica Matthews.
In season five, Will and Kate's baby, Emily, is treated at a cystic fibrosis unit in Bristol, which is named after Vanessa Machin, a cystic fibrosis sufferer (played by Susannah Corbett) who appears in episode Other Lives (1995).
The house in Wessington, which was used as the location for David and Clare Shearer's house, was owned by Tim Parkin, the Medical Advisor to the program.
Jack Kerruish's car (Series 1-3) was a silver Bristol 405, registration VUB 405, made in 1955 and last taxed in 1999.
Only 7 of the 12 seasons have been released on DVD.
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