Trivia

Several versions of the film are in distribution. The official US version is 76 minutes long. There is a European/UK (Polygram) version that is 102 minutes long. Director/writer Albert Pyun has said in interviews he intends to restore and release a 110 minutes Director's Cut restoration of the film. This version is set entirely in Romania and has only a minor virus aspect in its plot.

The film was heavily re-edited and reshot under orders of Bob Weinstein of Dimension Pictures. The major changes installed by Weinstein were resetting the film from Romania to Boston, U.S.A. and making the virus infection the principal plot device. Future Rogue Pictures president, Andrew Rona, supervised the re-edit for Dimension Pictures. The rewrites for the reshoots were done by Rand Ravich who would later create the short lived TV series "Life".

Stylistically, director Albert Pyun wanted to create a real time experience and shot the film as a news crew might cover a war. There was less reliance on narrative and traditional movie plotting, with the film being more akin to a documentary style, where action revealed the story and character. Pyun wanted longer takes with less coverage for editing to give the audience a "you-are-there" feeling.

The film takes place in 2007.

Director Albert Pyun shot Nemesis 4 in between taking part in reshoots for this movie.