26 stories from the original Franco-Belgian comic book series were adapted loosely for this series. Although the overall plot-lines and most characters stayed intact, many story details were changed, creating more humor. The best known example of this is giving the brainless dog Rantanplan a role in every story, while in the comic he mostly appeared in stories involving the Dalton gang. Another change was having Lucky Luke narrate the story.
Croatian music duo Sunci used scenes from this series to make a music video for their hit song Lucky Luke.