Johnny Depp and ex-wife Amber Heard first met while making this film. They became a couple in 2012 after Depp separated from his longtime girlfriend Vanessa Paradis, were married in February 2015, separated in May 2016 and officially divorced in January 2017, after a very public court battle, which was reignited in 2019 when Depp sued Heard for defamation.
Johnny Depp suspended his sobriety for this film in order to experience the effects of liquors depicted.
Marks the second time that Johnny Depp appears in a movie adaptation of a Hunter S. Thompson novel. The first time was Fear and Loathing in Las Vegas (1998).
The final black and white still shot at the very end of the movie is not Puerto Rico, where the movie takes place, but Aruba. The author is shown sitting on a bench at the Aruba Palm Beach Club with a bottle of Amstel beer. The Aruba Caribbean Hotel, in the background, was the first resort hotel constructed on Palm Beach. The author visited Aruba while living in Puerto Rico. The photo is also the book's cover photo.
The name of the restaurant from which Kemp and Sala are chased, "Café Cabrónes", translates roughly to "Coffee Bastards".
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