Queen Latifah originated her character, Gina Norris, in Barbershop 2: Back in Business (2004). Beauty Shop (2005) is a part of the same cinematic universe as the Barbershop (2002) franchise, but takes place in Atlanta, not Chicago.
The last Metro Goldwyn Mayer film to be released on VHS.
Djimon Hounsou and Kimora Lee Simmons started dating two years after this film's release, and had one son together. They broke up in 2012.
Gina's main inspiration in the film is Madam C.J. Walker. Octavia Spencer, who is credited as "Big Customer" (the lady who declines the cappuccino), would go on to portray Walker in the miniseries Self Made: Inspired by the Life of Madam C.J. Walker (2020).
The video store next to Gina's Beauty Shop is called "The Big Picture", which is a nod to The Big Picture (1989), a film starring Kevin Bacon.