During the scene where an armed helicopter assists Leon in cleaning out the bad guys, the helicopter pushing over the fuel tank doesn't make a sound until it is revealed by the camera. The Ganados are alarmed only by the creaking sounds of the tank. The helicopter makes so much noise that they should have heard it coming long before it arrived at the tank.
Verdugo, Salazar's "right hand", pierces holes through the floors and ceilings with its tail, yet these holes don't stay there when the tail is retracted.
In the beginning of the second chapter, Leon kills one of the villagers and his body is left in a corner of the room with blood stains and his weapon lying next to him. However, once the player resumes control over Leon, the villager along with his weapon and bloodstains have completely disappeared.
During game play, Leon is dragged around the lake in a boat after a rope tied to the boat's bow gets wrapped around the tail of the lake monster. However, after the monster is defeated, the rope is suddenly no longer tied around the monster's tail, and gets wrapped around Leon's leg. If the rope is loose enough to untie itself from the bow of the boat, then Leon wouldn't have been dragged around in the first place.
In one camp area within the village, where the players first encounter The Bella Sisters, it's necessary to defeat one of the sisters in order to get a key that unlocks a locked door that leads further into the camp which leads to the exit to the next area. However, if the player encounters the sisters with Ashley accompanying them, any villager that captures her can simply push the locked door open, enter it and immediately lead to Mission Failure.
Near the end of the game, Ada is shown belly flopping off a platform directly over a rising helicopter. Seconds later she's safely seated inside the rear passenger seat of the helicopter when her leap would have lead to her death.
An enemy is shown firing a homing missile from an RPG-7. RPG-7s only fire unguided rockets.
Leon is shown continually throwing his combat knife during cut-scenes and accurately hitting his targets. The type of knife he's using is designed for close quarters combat. It would be impossible to throw a close-quarters combat knife because it's too heavy between the handle and blade, it's not aerodynamically shaped or evenly balanced between handle and blade and would never effectively hit any of his targets.
The jet ski at the end of the game isn't tied down to anything and yet the water current doesn't move it at all.
Although walking into bear traps can hurt Leon and Ashley, the villagers can walk through bear traps unaffected.
Leon and Ada constantly leap off of tall/very high ledges during game play, but they never get hurt when they land regardless of the height.
During a cutscene, Leon enters a barn that leads to a boss battle against the village chief. The village chief was able to enter the doors silently behind Leon's back without him even noticing. In fact, the village chief entered the barn without even opening the doors.
In the chamber where you first meet Salazar in a cutscene, during gameplay, there's no one on the balcony, but then a shot later, when the cutscene starts, Salazar and two Verdugo appear.
The cannon that Mr. Kennedy uses to destroy a gate isn't pointed directly at the gate when it fires.
One mechanism for crossing a pit consists of two toothed wheels with a platform in between. There is nothing keeping the platform level.
It is possible for the Player to break through what appears to be reinforced glass - which is difficult to break.
Weapons and equipment are carried in a briefcase, but Mr. Kennedy isn't visibly carrying a briefcase.
When reloading the Rifle (standard; wii Edition only), The speaker (on the wii remote) finishes the sound but Leon isn't finished reloading. Upgrading the reload speed once, however, will fix this. This also happens with the Semi-Auto Rifle.
When you reload the Mine Thrower, it, like the Rifle (Standard and Semi-Auto), finishes the sound on the Wii Remote about 2 seconds before Leon finishes reloading. Again, upgrading the Reload Speed once, will fix this.
The game is set in Spain, but the natives speak a Latin-American dialect of Spanish (The most obvious example to a native speaker is the use of "aca" instead of "aqui" which means "here").
Leon and Ada continually get captured during the course of their scenarios, yet every time they get captured, their weapons and items stay on them. Who captures someone they intend to kill or torture but leaves that person's weapons on them in case they feel like breaking free and retaliating?
Any time Ashley gets recaptured by the villagers during game-play, it leads to Mission Failure. However, every time Ashley is recaptured during a cut scene, the mission to rescue her continues.
Leon is equipped with a very heavy duty knife. However, he never uses it to simply cut the rope when the boat is caught by the lake monster, and instead allows himself to be dragged around at a disadvantage until the battle is over.
Despite having numerous weapons at his disposal, such as a Handcannon, Chicago Typewriter, and a Rocket Launcher, Leon only uses a harpoon to defeat the lake monster, when he uses those available weapons for every other enemy.
Salazar knew about Leon before they even met. In fact, Salazar was able to jack Leon's communication radio without meeting him first.
Salazar calls Mr. Kennedy 'Mr. Scott'.
When the helicopter arrives, it doesn't shoot at enemies except in cutscenes.