While tracking a young boy with dangerous powers, Dr. Helen Magnus encounters Will Zimmerman, a psychiatric resident who may have what it takes to become her new protege.
Will learns that "Sanctuary for all" is a motto Helen Magnus takes very seriously, as they begin the seemingly insurmountable task of relating to the boy they think is responsible for the recent crimes.
Revelations lead to confrontations. When secrets from Helen's past refuse to remain hidden, what will the ramifications be for Ashley and the rest of the Sanctuary team?
The Sanctuary digs further into the mystery of the three sisters, and what they might be capable of. Meanwhile, Ashley continues trying to exorcise her own personal demons.