Rivals Buster and Plucky decide to throw an epic Pizza Party and are shocked to find out they're actually getting along, while Babs and Sweetie get into their first roommate disagreement.
Babs realizes Acme Loo's school paper has closed, so she starts a new one with her pal Sweetie, but, when Plucky starts a gossipy tabloid to compete against them, which paper will come out on top?
Buster and Sweetie join the Tooney Ball team during Electives Week while Babs and Plucky tackle the basics in Anvils 101, leaving Hamton on a journey to fix his indecisiveness.
Buster, Plucky and Hamton must save the Loo Bru from Montana Max who intends to tear it down while Babs and Sweetie lets Dizzy stay in their dorm room, but he soon becomes an annoying roommate.
Hamton gets into medical school but soon realizes it's not at all what he imagined. Buster desperately tries to find a way to bring his pal back to Acme Loo.
Buster finds a cloning machine at Wile E. Coyote's yard sale that he uses to make another Buster, Babs and Sweetie snag a time machine that they use to open a vintage clothing store.
Babs is excited to be the first student director of the annual toon showcase, but she quickly learns it won't be as easy as she thought. Meanwhile, with the help of his friends, Hamton learns to shine in the spotlight.