This video game takes place in the Normal Timeline of the Pokémon multiverse, together with Pokémon FireRed Version (2004), Pokémon LeafGreen Version (2004), Pokémon Emerald Version (2004), Pokémon Platinum Version (2008), Pokémon SoulSilver Version (2009), Pokémon Black Version (2010), Pokémon White Version (2010), Pokémon Black Version 2 (2012) and Pokémon White Version 2 (2012).
The main male character of Gold now is called Ethan.
The new main female character is called Lyra, replacing to Kris.
Giovanni appears on this video game unlike of the original games that does not appear.