The title is director David Lowery's "mondegreen" - a mishearing of a song lyric - and has no actual meaning. He had been wanting to use it as a movie title for years.
Director David Lowery said Rooney Mara (Ruth) was the only actress he met with, and Casey Affleck (Bob) was the first actor he met with, "I had a gut instinct of who would be perfect for these roles. It was those actors. Luckily for me, they said yes."
Rami Malek originally auditioned for the role of Sweetie, but the role went to Nate Parker. However director David Lowery was so impressed with Malek's audition that he decided to give him the small role of Will later in the film.
Rooney Mara on her accent in Ain't Them Bodies Saints (2013), "I worked with a coach a few times, but it's such an easy accent to pick up because we've grown up hearing it. It's easier to pick up as an American. I just feel like I've been hearing it my whole life."
In an interview for Ain't Them Bodies Saints (2013), Rooney Mara revealed her character Ruth, and Casey Affleck's character Bob, have known each other since they were "12 years old."