The 2nd unit crew took a camera vehicle on the exact Cincinnati-to-Chicago route depicted in the movie to provide geographically-accurate backgrounds.
Nikki's mention of the "Bewitched" TV show in the opening scene was an inside nod to a show where a main character is portrayed by two different actors (Dick Sargent replaced Dick York in that series); Juliana Allen replaces Pamela Brumley in "Nikki and the Perfect Stranger" (2013).
Nikki's personal vehicle is a Jeep Liberty; in the original movie, she drove a late-model Lexus SUV--a storyline nod to her new scaled-back lifestyle.
Based on David Gregory's third 'Perfect Stranger' novel, 'Night with a Perfect Stranger'.