"Brother Nature" is reminiscent of countless comedies, ranging from "What About Bob" to "The Great Outdoors." It's one of those classic formulas where a straight-faced, straight-laced guy (in this case, Taran Killiam, from "SNL") encounters someone who is obnoxiously wacky and has a potential mean streak that no one else ever seems to notice (Bobby Moynihan, also from "SNL").
Killiam's character becomes more and more exasperated, and there are hints at times that Moynihan's character is deliberately sabotaging him a la "The Cable Guy." The first half is quite funny -- Killiam is a weak lead, but Moynihan is hilarious, and has a number of moments that made me laugh out loud.
But they don't really go anywhere with the idea that Moynihan is subversively destroying Killiam (the film seems to hint at it, and then promptly drops it); they also opt for a safe conclusion by fundamentally changing the nature of Moynihan's character, as, in the first half, he's an obnoxious goofball who no one would ever like, but towards the end he's suddenly a calmer, more sympathetic version of the same character, as if his apparently intentional attacks on Killiam earlier in the film never happened.
Whether this is studio intervention (the ending certainly seems like something that would be tacked on after poor test screenings), who knows, but ultimately this movie goes from a 7/10 to a 5/10 simply because its second half egregiously missteps and the movie is never able to recover from it.
Those early scenes with Moynihan, though, reveal great potential for the actor.