Episode titles are seemingly three nonsense words but are actually anagrams. For example, "Eight Slim Grins" can be rearranged to "The Missing Girl" or "Missing the Girl". "A Stray Howl" can be decoded as "Taylor Shaw". Also, the titles for season 2 episodes 10 - 22 are the same backwards. This only occurs for an episode title one other time and that's for the series finale (S5E11).
For the first episode Jane Doe is found in Times Square. To get a real effect Times Square was shut off just so they could film the scene.
Jaimie Alexander must sit in the make-up chair for 7 1/2 hours to have all the elaborate tattoos applied to her body for each day's shooting.
In one scene Zapata makes fun of Patterson for playing "wizard and elf games" and refers to Patterson as "elf". Patterson corrects her by stating proudly that she is a gnome cleric. In reality, Ashley Johnson does indeed play a gnome cleric in a Dungeons & Dragons game with other well known voice actors on the Geek and Sundry show Critical Role.
Ashley Johnson can be seen throughout the show with a mug that says "Critical Role." Critical Role is the a name of a Dungeons and Dragons Twitch stream starring Ashley Johnson and other voice actors.