Dash Shaw has known Jason Schwartzman for many years through comic books. He met him after Dash's comic book called, "Bottomless Belly Button" had come out and has always kept in touch.
The first time Dash Shaw (the director/writer/animator) saw that he could make gifs in Photoshop, could line up images, and that Photoshop could arrange them in short animations, he realized that he didn't need a multi-pane camera the way Disney needed a camera. He could use a scanner and make animations with the same tools he uses to make comics.