Blame! throws us into an unknown far-future post-apocalyptic setting that's unlike most post-apocalyptic settings we're used to. Natural formations like land, sea, sky, plants, and rocks are completely non-existent and what we are left with is a colossal, cavernous, metaled mess of a megastructure. Any adjective with the basic meaning of "large" that I could have chosen to describe this structure should be seen as an understatement since - according to the manga from which this film is based on - the megastructure itself, which initially started on Earth, now extends past the orbit of Jupiter.
The massive labyrinth interior of the megastructure is created and maintained by "Builders" (giant skeletal, mechanized creatures who slowly roam around)and to us humans, their design theory can probably be best summed up as ordered chaos gone amok. The viewer is overwhelmed with scene after scene of grand metal-type architecture. One can't wait to see what fresh, new, metallic gloomy backdrop is waiting around each and every corner. The animation used to depict this cold and miscalculated world is phenomenal. Based on this reason and the given "nature" of the setting, any viewer who is attracted to films because of their dark atmospheres should give this one a try.
Not to say the story is dull by any means. Plot elements include a tribe that's on the brink of destruction who question whether they are the only humans left, hyper robots with spider-like bodies and ultra-artificial human faces who eliminate humans upon detection, a wandering protagonist with a synthetic body and a super gun, a female engineer sidekick with Netsphere (cyberspace)insight and the ability to transfer her consciousness into reanimated forms, and that's just to name a few. This is a sci-fi nerd's wet dream.
Some might criticize the protagonist's quiet and shadowy attitude, but I suppose it fits since who knows how long he has been wandering around for. Maybe thousands of years? I found myself longing to know more about his own history, the sights he'd seen, and the experiences he'd had along the way.
My own point of criticism would be the children characters' "coming of age" story whose names, faces, and personalities seem to all run together. Their part in the film should probably be included, but maybe with a little less focus and their characters a little more distinguished.
One warning I give to the potential viewer is there are some sci-fi concepts in the film which are unexplained and rely wholly upon the audience's familiarity with sci-fi in general. Some examples of these concepts are transhumanism and theoretical replication technology.
Have fun watching Blame!. I thought it was a blast!