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Autoimmune disorders

SLE B cells take an extrafollicular detour after mRNA vaccination

Nature Immunology volume 26, pages 4–6 (2025)Cite this article

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Systemic lupus erythematosus (SLE) is an autoimmune disease with considerable clinical heterogeneity and diverse treatment options. A study now shows that heightened extrafollicular B cells and anti-BAFF therapy are linked to inferior responses to COVID-19 vaccines.

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Fig. 1: Aberrant B cell responses to mRNA vaccine in SLE.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Sokratis A. Apostolidis

  2. Department of Microbiology, University of Pennsylvania, Philadelphia, PA, USA

    Michela Locci

Authors
  1. Sokratis A. Apostolidis
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  2. Michela Locci
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Correspondence to Sokratis A. Apostolidis or Michela Locci.

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All authors have no competing interests.

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Apostolidis, S.A., Locci, M. SLE B cells take an extrafollicular detour after mRNA vaccination. Nat Immunol 26, 4–6 (2025). https://doi.org/10.1038/s41590-024-02035-0

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