Genome-wide transcriptomics analysis of IFNγ-producing or IL-17A-producing γδ T cell subpopulations reveals marked differences in their mode of activation and functional potential in the periphery. We describe the differential expression of a set of 20 signature genes in models of infection and autoimmunity that may be useful for future studies on γδ T cell functions.
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This is a summary of: Inácio, D. et al. Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation. Nat. Immunol. https://doi.org/10.1038/s41590-024-02073-8 (2025).
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Functional signatures and activation mechanisms of effector γδ T cell subsets. Nat Immunol (2025). https://doi.org/10.1038/s41590-025-02098-7
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DOI: https://doi.org/10.1038/s41590-025-02098-7
