Ageing articles from across Nature Portfolio

Single-nuclei multiomics analyses of ovarian tissue from young and reproductively aged individuals reveal mTOR signaling as an ovary-specific aging pathway and identify functional genetic variants associated with ovarian aging. This comprehensive atlas provides insights into molecular and genetic mechanisms of ovarian aging and potential therapeutic targets for reproductive longevity.

Older female mice show poor spatial memory when their paternal X chromosome is inactive and only the maternal copy is active. This phenomenon could be responsible for variation in age-related cognitive decline among women.

Using single-cell imaging of a fluorescent chaperone-mediated autophagy (CMA) reporter and RNA sequencing data, the authors present a resource on basal CMA activity across organs, cell types and sexes in young and old mice, offering a comprehensive overview of changes in this proteostatic mechanism in the context of aging.

Using multi-omics analysis, Zuo, Zhao, Wu, Wang, Wang and colleagues report disrupted branched-chain amino acid (BCAA) catabolism in skeletal muscle samples from patients with sarcopenia. In mouse models, they causally link BCAA catabolic dysfunction to impaired muscle mass and demonstrate the translational potential of enhancing BCAA catabolism.

Single-nuclei multiomics analyses of ovarian tissue from young and reproductively aged individuals reveal mTOR signaling as an ovary-specific aging pathway and identify functional genetic variants associated with ovarian aging. This comprehensive atlas provides insights into molecular and genetic mechanisms of ovarian aging and potential therapeutic targets for reproductive longevity.

The anti-ageing effect was even greater when combined with vitamin D and exercise.

Older female mice show poor spatial memory when their paternal X chromosome is inactive and only the maternal copy is active. This phenomenon could be responsible for variation in age-related cognitive decline among women.

Researchers are exploring how to prolong ovarian life and revisiting hormone replacement therapy — a once routine treatment that has fallen out of favour.