Thrombocytopaenic purpura articles from across Nature Portfolio

Producing recombinant human IgG1 Fc fragment in serum and egg yolk of transgenic chickens have higher sialylation and low fucosylation which increases the affinity of the Fc to its receptors and exerts anti-inflammatory effects in vitro and in vivo.

Tania Rowley et al. present multivalent Fc molecules with enhanced avidity for Fc gamma receptors in order to improve the treatment of autoantibody-mediated human diseases. They found several key amino acids involved in Fc receptor binding interactions.