Drugs Generally Used in Clinics

No. Name (1) Enrofloxacin (Fluoroquinolone) BrandName Gyroflox 100mg/ml Bayrocin Content/M.O.A. Enrofloxacininhibitsthe enzymeDNAgyrase responsibleforcoilingand supercoilingofDNAthus producebactericidaleffect Indication Acute&Chronicmastitis, Respiratorytractinfections Pneumonia,H.S.,B.Q., Pyometra,metritis,jointill, Urogenitalinfections,Otitis, Brucellosis,Salmonellosis. Dosage Animal 2.55mg/kgBW PoultryRefertoCINVEX Precaution Contraindicatedin (1yrsofage)Not recommendedin horses.

(2)

Meloxicam (oxicamNSAID) injection

DiclovetM DisovetM 5mg/ml

InhibitsthesynthesisofPGE2 bymoreselectivelyinhibiting theCyclooxygenase(cox2) enzymestherebyexerting PotentAntiinflammatory, Antiexudativeanalgesic& AntiPyreticeffect.

Animalsinflammatory conditionsassociatedwith Pneumonia,Pleuritis,mastitis, ProlapseofUterus,laminitis, myositisArthritis,and Prematurelabour.

PneumoniaProlapsed. C/B/S/G/D/H 0.5mg/kgBW OtherConditions. C/S/G/P/D/H/0.20.3mg/kg Oraldosedog0.2mg/kgBW Maintenance0.1mg/kg

Donotusein animalssuffering fromGastro intestinaldisorders, impairedhepatic cardiac&renal functions.

(3)

Chlorpheniramine

CadistinTMvet

Chlorpheniramine Maleateexertsh1recptor antagonistactionalongwith AnticholinergicandSedative effect.

(AntiAllergicDrugs) CHLORAZIN H1Blocker (Alkylamine) 10Mg/ml

Cattle 3050mg(totaldose) Allergicdisorderlikeeczema, Urtiearia,skinedema,Photo Dog0.42mg/kgBID dermatitis,Dermatitis,rhinitis, Pregnancytoxemia,RFM, Mastitis,burn,Anaphylactic Shock,Rumenotomyincattle

Sedations,CNS excitement,GI disturbances, teratogeniceffect.

Shirish Bhatia

Drugs Generally Used in Clinics

No. Name (4) GENTAMYCIN (Aminoglycoside antibacterial) BrandName Cadila 40mg/ml Content/M.O.A. Gentamycininhibitsbacterial ProteinSynthesis,thus exertingbactericidalaction Indication Urinarytractinfections mastitis,metritis,wound infections,Pyometraotitis Pneumonia,CRD. Dosage C/S/G/P/D 4mg/kgBWBID Poultry35mg/kgBW Precaution Contraindicatedin pregnancy.Avoid Aminoglycosidesin cowspronetomilk fever. Intraarticularinj. Contraindicated. Avoidinpups& pregnant (6) ANALGIN/ MENTAMIZOIE (NSAID)Imidopyrin analgesic. VETALGIN 0.5 gram/ml Analginhaveapotent Pain,fever,rheumatoid analgesicAntiinflammatory& conditions,Spasticcondition Antipyreticaction. colic&Otherinflammatory conditions. Cattle 1020gm. Horse1030gm. Foal,calf2.57.5gm. Pig515gm. S/G14gm. D/C0.52.5gm. Hypersensitivity reactionmayoccur.

(5)

Oxytetracycline (tetracycline congener)

50mg/ml

Oxytetracyclinehas bacteriostaticaction,asit OTCL.A.200mg/ml inhibitsbacterialProtein Synthesis.

H.S.,B.Q.,Anthrax,pneumonia C/S/G/H/ 510mg/kgBW enteritis,genitourinarytract Dogcat1020mg/kgBW infections,mastitis, Brucellosis.

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Drugs Generally Used in Clinics

No. Name (7) NeuroxinMTM TradeName M.O.A. Indication Dosage Precaution

Cattle/H 510mlODI/M Injectionofmethylcobalamine Neurologicaldisorders, DeficiencySyndrome,Debility, ,vit.B6,Nicotanamide, Dog,Cat23mlODI/M Methylcobalamine500mg, andWeakness. PyridoxineHCLIP50mg, NicotonamideIP50mg. Allanimal&poultry Mixed Largeanima 1530mg/kgBW. bacterialinfectionaffecting Dog15mg/kgBW. respiratorytract,Urinarytract, Alimentarytract&Genital tract.

(8) (9)

COtrimoxazoleINj. (Diamino pyrimidine potentiated sulphonamide)

ORIPRIMVVetInj. PotentiatedSulphonamide 30ml inhibitsformation&Reduction ofbacterialDihydrofolicacid Trimethoprim80 effectingblockadesof mg bacterialDNAsynthesis& bactericidal. Sulphamethoxazole 400mg

Doberman pinschersKerato conjunctivitis& Transientarthritis.

IVERMECTIN (Avermection derivative)

IVECTION 10mg(1%W/V)

ItpotentiatesGABArelease, increasingthenormalresting potentialofpostsynapticcells andintumblockingNeuro transmission&worms undergoflaccidparalysis.

Nematodalinfections, ectoparasitesliketick,lice, mites&nasalbotsinS/G. cutaneousmyiasis,larvalstage ofcanineheartworm (microfilariae)ectoparasitic demodecticmange,cutaneons myiasis.

C/S/G/H/P/D/ 200g/kgBW S/C 10mg/50kgBW S/C.

Ineffectiveagainst trematodes, cestoedes&adult canineheart worms,Toxicto certainbreedsof dogs.(Collie).I/V& I/Madministration shouldnotbedone

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Drugs Generally Used in Clinics

No. Name (10) Conciplexinj. TradeName Highpotency vit.B complexinj. M.O.A. ThiamineHCL33.3g PyridoxineHCL3.3g Cynocobalamine33.3mcg Nicotinamide33.3g Riboflavin5mg Phosphatesodium1.66g Dpanthenol1.66g Benzylalcohol0.9%W/V. (11) VETADE Vit.AD3EINJ. Vit.A 250000IU Vit.D325000IU Vit.Eacetate100mg/mc Benzyl/AlcoholIP2%W/V. Deficiencyconditions,Repeat breeding,Poorconception rate,Xerophthalmia,Night blindness. 10mlvial Indication Anorexia,debility,anemia, deficiency,diseases. Dosage Largeanimals10mlOD Smallanimals35mlOD Inj.10mlvial Inj.30mlvial. Precaution

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Drugs Generally Used in Clinics

No. Name TradeName M.O.A. Indication Dosage Precaution Notuseinpuppy because Restlessness, excitement, extrapyramidal symptomsinyoung ones. Penicillium hypersensitivity reactionsmay occur.

(12) METOCLOPROMIDE PERINORM10ml (Antiemetic)HCL Metoclopramide HCLIPequivalentto Anhydrous Metoclopramide hydrochloride5mg. (13) Amoxicillin +Sulbactum combinations.(Semi syntheticB lactamaseinhibitor) AMOXIRIUM FORTE300mg

Dog,cat 0.20.4mg/kgBW Metaclopramidehavespecific VomitingduetoGastritis dopamineantagonisticaction Oesophagealrefluximpaction. (oral) blockingtheDopamine 0.010.2mg/kgBW(Inj.) receptorwhichinduceemesis &alsoincreasegastricmotility &emptyingthegastriccontent toposteriorsegment. LargeAnimals34.5gODBID SmallAnimals300mgODBID

Sulbactumisapotenthighly RTI,Otitis,UTI,skin andsoft specificirreversibleinhibitorof tissueinfection.Mixed Blactamasesproducedby bacterialinfections. Amoxycillinsodium Gve&G+veaerobes& 200mg anaerobesexertingitsaction Sulbactumsodium bybindingitselfwiththese enzymes&blockstheir 100mg destructivehydrolyticactivity. Calciumlevulinate76.4 mg.(equivalentto10mgionic calcium)Cholecalciferol5000 IUCyanocobalmine (vit.B12)50mcg/ml BenzylAlcoholIP1.5%W/V

(14) CALDEE12 Multipledosevial 30ml

Hypocalcaemia(prevention& Large1015mlthriceweakly treatment)debility,weakness. Small13mlthriceweakly Inj.30mlvial.

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Drugs Generally Used in Clinics

No. Name (15) FERITASIRTAS TradeName IRONSORBITOS, FolicAcid&VitB12 inj.10ml M.O.A. Iron , sorbitol, citricAcid complex50mg FolicAcid500mcg. Hydroxocobalaemineacetate 50mg/mlwaterforinj.I.P. Indication Postantparasitic treatmentin caseofecto&endoparasitic infestation,bettergrowthof youngcalves&morethanone weekpiglet,PregnantAnimals. Dosage Cattle,Horses2boliOD10 15dayscalf,sheep,goat bolus ODfor1015days/H/calf/S/G 1ml/50kgBWIM Piglets0.2mlI/M Precaution

(16) Dicycloverine Hydrochloride (Dicyclomine) Antispasmodics.

Spasmovet 30ml BenzylAlcohol2% v/v.10ml

Renal,Ureticcolic,Spasmodic Act onG.I.tract, biliarytract. Ureter&uterus,Reduas Pain. SpasmswithoutProducingany antisecretoryeffects.It attributesnonspecificdirect relaxantactiononsmooth muscle.

C/B/S/H/G 0.5mg/kgBW (I/M) Dogcat10mgQID(totaldose)

Nottobeusedin newborn. Premature,Oldor debilitated Animals,frank urinaryretention, Pyloricorduodenal obstructions.

Shirish Bhatia

Drugs Generally Used in Clinics

No. Name (17) DEXAMETHASONE TradeName Dexondvetinj. M.O.A. Dexamethasoneenhances CHOandproteinmetabolism, Hb,Redcells,modifycell mediatesImmure(CMI) responsealsohavepotent antiinflammatoryaction. Indication Acuteinflammation,bursitis, retinitis,Arthritis,Allergicskin disease,hypersensitivity reactions(Asthma),shock tissuedamage,toxemia,stress fromtrauma,disease, environment,emotions& fatigue. Dosage IM/IV(Totaldose) Cattle1030mg Calf/G/S/P25mg Dog0.52mg Cat0.250.5mg TA/PERIARTICULAR Cattle410mg Dog0.255mg Cat0.252mg ORAL Dog0.255mg Cat0.252mg Precaution Latepregnancy, Recentmajor surgery,deep cornealulceration, diabetesmellitus, cardiac insufficiency,Renal disease.

(SteroidAnti RxDexamethasone inflammatoryGluco IP.5ml corticoid. Sodium (Syntheticanalogue) Phosphatesinj.

DexamethasoneNaPinj. 4.4mgequivalentto InductionofParturition. dexamethasonep4mg dexamethasone3.344mg Large40mgI/V. MethylparabenIP0.15%W/V. PropylparabenIP0.22%W/V.

Shirish Bhatia

Drugs Generally Used in Clinics

No Name M.O.A. Indication Indication Dosage DROPS15ml Precaution

(18) OFLOXACIN (19) VirbacEPIOTIC (20) RANITIDINE(H2 antagonist) .

OTIRELEarDrops Ofloxacin+Clotrimoxazole+Betamethasone+ Eyeconjuctivitis, keratitis, cornealulcer,blepharitis, Vetnex Lignocaine. hordeolum,trachoma. OfloxacinIP0.3%w/v Clotrimazole1%w/v Betamethasone0.025%w/v Lignocainehydrochloride25w/vin glycerinebase Salicyclicacid. EarCleanerfor dog&cat. Salicyclic acidIP0.2%w/v PhenoxyethanolBP0.23%w/v ColorBrilliantblueFCC RANTACinj. Rinotacinj. Ranitidinepreventshistaminemediated gastricacidsecretionbyblockageof HistamineH2receptors. Ranitidine4HClIPequivalenttoRanitidine 25mg. PhenolIP0.5%w/v Gastritis, Gastric/ Duodenalulcers. Regularearcleanser, Pre treatmentofOtitis. EarOtitis

Dog,Cat 0.5mg/kgBW I/m,I/v,S/c,Oral

Avoidusein pregnancy, lactation,renal disorders.

Shirish Bhatia

Drugs Generally Used in Clinics

No Name TradeName VirbacEFFIPRO 80ml M.O.A Indications Dosage SPRAY0.25%w/v Precautions (22) Hydrogen PeroxideSolutions (23) GotBac40gm. Composition: Permethin2%w/v SulphonamideBP5%w/w ZincoxideIP2%w/w Fxcipientsq.s. Purifiedwater6.0%w/v20volume Disinfectantforcleansing woundandasadeodorant mouthwash,strong solutionsirritatetheskin. Forthetreatmentof Myiasis&penetrationof Flystrike. Permethin,sulphonamide andzincoxidepowder. PotentLarvicidal& bacteriostaticpowderfor woundandtissue regeneration.

(21) FIBRONIL(Phenyl pyryazole acaricide)

Fibronilexertsitsactionbyselectively Ectoparasiteinfestations. blockingthepassageofchlorideions Cutaneousspraysolutions throughtheGABAreceptorandglutamate fordog&cat. receptorwhichdisruptstheinsectscentral nervoussystem.

Shirish Bhatia

Drugs Generally Used in Clinics

No Name TradeName M.O.A Butaphosphan0.1mg Cynocobalamine50mcg/ml Indications Toimprovemetabolism andstrengthenresistance, inconvalescence,astonic, toimprovemuscular efficiency,assupportive therapyinhypocalcemic paresis,anoestrus, bacterialinfections, helminthinfestations. Dosage Cattle,Horse1025ml Calf,Foal512ml Sheep,Goat2.58ml Lamb,Kid1.52.5ml Dog0.55.0ml Cat0.52.5ml Pig2.510ml Precautions (25) DIAZEPAM Anxol10mlI/m DiazepamproduceCNSdepressioninthe Statusepilepticus, orI/V brainstemreticularformationbyblocking convulsionsdueto thespinalpolysynapticreflexes. poisoning. BenzodiazepinespotentiatesGABA mediatedinhibition.Diazepamhassedative andtranquilizingeffects. Dog, Cat0.51mg/kgBW IM,IV. Intravenousover dosagemay produce respiratoryarrest.

(24) CATOSAL10%inj. 30ml

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Drugs Generally Used in Clinics

No Name TradeName M.O.A Indications Animals arthritis,myositis ,tendinitis,bursitis, inflammation,allergic bronchitis,asthma,food allergy,Hydrocephalus, atopy,contact&flea allergy. Urethritis,persistent hematuria. Dog0.5mg/kgBWBID orally URETHRITIS,PERSISTENT HAEMATURIA Cat2.55mginevery24 48hrsorally. Dosage IM1%soln Precautions

(26) PREDNISOLONE (Steroidalanti inflammatory drugs) Glucocorticoid

Prednisolonehastypicalmetaboliceffects Prednisolone acetateBvetc10 ofnaturalcorticosteroids.Itmodifies mg/ml immuneresponseanditishavinganti inflammatoryaction.Itssynthetic Vetaquinolinj. analogueshaveverygoodanti inflammatoryeffects.

Glaucoma, Pregnancy, Horse,Cattle0.5mg/kgBW degeneration, jointdisease, Calf,Pig2.55ml(Total osteoporosis, Dose) fracture,diabetes Dog,Cat13ml(TD) mellitus, infections,renal LOCALTREATMENT disease. Largeanimals2.57.5 Notmorethan10 ml(TotalDose) withdrawals Dog,Cat0.52ml(TD) permitted. CANINEATOPY,CONTACT ALLERGY,FLEAALLERGY

Shirish Bhatia

Drugs Generally Used in Clinics

No Name TradeName PovidoneIodine solutionIP WinMedicine M.O.A Betadineantisepticsolutionshasarapid andprolongedgermicidalactionagainsta widespectrumofpathogenicorganism includingbothGram+veandGramve bacteria,fungi,protozoaandviruses.Itis alsoactiveagainstbacterialspores.Inthe presentofblood,serum,purulentexudate andnecrotictissue.Itsactivitypersistas longasthecolorremainstheGoldenbrown colorservetohighlightthedisinfected area. Indications Degerminatingofskinpre &postoperativelyfor surgicalproceduresforthe antiseptictreatmentof superficialwound ,traumaticinjuries,burns, vaginalpreparationpriorto asurgicalprocedure. Dosage PovidoneiodineIP5%w/v (0.5%w/vavailableiodine) PurifiedwaterIPq.s. Rs.277.60 Precautions

(27) BETADINE (28) PIPERAZINE (Anthelmintic) (Topical Antiseptic)

Piperagineliquid 45%w/v2.25 gm.

Piperagineinducesneuromuscularhyper Gastrointestinal polarizationintheworms,producing Nematodiasis. reversibleflaccidparalysis,whichprevents itfrommaintainingtheirpositioninthe hostsgutandtheyarevoidedwithfaces.

ORAL Cattle,Horse100ml Calf2030ml Dog25ml Poultry Grovers40ml/100birds Layers5075ml/100bird

Overdosage occasionally produceemesis (indogsandcat), diarrhea, incoordination, headpressingand other neurological signs.

Shirish Bhatia

Drugs Generally Used in Clinics

No Name TradeName Lasix (Furosemideinj.) 2ml 10mgI/mor slowI/v M.O.A Activeabsorptionofsodiumandchloride fromtheultrafiltrateattheluminalphase ofloopcellsisreduced.Thisactionis coupledwithincreasedmedullaryblood flow,reducesintestinalhypertonicityand thusreducesthereabsorptiveefficiencyof loop. Indications Acutepulmonaryedema , cerebraledema,ascites, CHF,postparturient edema Dosage Precautions

(29) FRUSEMIDE (30) NIMESULIDEinj. (NSAID)10%w/v (Loopdiuretic)

Dog,Cat24mg/kgBWBID Deafnessisan adverseeffect Cattle12mg/kgBW peculiartoloop diuretics.This tendencyfor ototoxicity contraindicates concurrent therapywith aminoglycoside antibiotics.

NIMOVET

Selectivelyinhibitsthecyclooxygenase (COX2)enzyme,therebyexertingpotent antiinflammatory,andantiinflammatory, antiexudative,analgesicandantipyretic effectswithdecreasedgastricirritation.

Symptomaticreliefofpain, pyrexiaandinflammation ofmusculoskeletalorigin, postsurgicalinflammatory conditions.

Dog35mg/kgBW C/B/S/G24mg/kgBW

Usewithcaution inpregnancy. Nosufficientdata availableforuse inHorses.

Shirish Bhatia

Drugs Generally Used in Clinics

No Name TradeName Sodiumacid phosphateinj. M.O.A Sodiumacid phosphate40.3%w/v Equivalenttoelementalphosphorus8% w/v MethylparabenIP0.18%w/v Propyiparaben0.02%w/v Indications Elementalphosphorus injectionforpost parturient haemoglobinuria,pica, infertility,systemic acidosis,indigestionand ketosis. Dosage IM,IV,SC Cattle,Horse510ml Foal,Calf13ml Dog12ml Forinfertility Cattle15mlon1st&3rdday Postparturient haemoglobinuria50mlIV (32) Albendazole (Benzimidazole anthelmintic) Albomar500ml Albendazoleoral suspensionUSP Eachmlcontain Albendazole25 mg Albendazoleinhibitpolymerizationof tubulinintheparasiteandblocksthe glucoseuptake.Itinterferewithenzyme fumaratereductaseandthustheenergy productionintheparasite.Energylevelsof theparasitediminishesanddeathresults.It haswormicidal,Larvicidal,andovicidal action. Nematodal,Cestodaland ORAL.5mg/kgBW trematodalinfections(both Cattle6090ml adult&larvalstage) Liverfluke&tapeworm Calf1530ml S/G23ml/10kgofBW Poultry3045mlfor100bird Dog35mltwicedailyfor 3days Precautions

(31) URIMIN30mlinj.

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Drugs Generally Used in Clinics

No Name TradeName ARTIZONESinj. 30ml M.O.A Phenylbutazonehaveantiinflammatory, antipyretic&analgesicactivity.Itproduces oxygentensionreductionandinhibits prostaglandinsyntheticbysuppressing cyclooxygenase(lysosomalenzyme)activity Phenylbutazone200mg Sodiumsalicylate20mg/ml Indications Pyrexia, symptomatic treatmentofinflammatory andpainfulconditionsof muscle,boneandjoint. Dosage IM,IV Largeanimal1020ml Precautions Contraindicated incatsduetohigh toxicity. Accidental ingestioninto carotidartery resultin excitement, prostrationand sometimesDeath.

(33) PHENYL BUTAZONE (Pyrazolone derivativeNSAID)

(34) BELAMYLinj.

Hepatobiliary drug

Thiaminehydrochloride10mg Riboflavin3mg Niacinamide100mg VitaminB1210mcg Crudeliverextract0.66ml

Acuteandchronicliver Largeanimal510ml disorder,hepatitis, Smallanimal0.250.5ml jaundice,fattyliver, cirrhosis,hepatotoxic conditions,aflatoxins, toxaemia,nonspecific anorexia,debility, weakness,anaemia,stress ofvariousetiology.

No

Name

TradeName

M.O.A

Indications

Dosage

Precautions

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Drugs Generally Used in Clinics

(35) QUINAPYRAMINE ANTRYCIDE PROSALTinj. 2.5gm. Quinapyraminesalts(sulphate&chloride) inhibitsthegrowthandcelldivisionof haemoprotozoans. Trypanosomiasis Surra Animals4.4mg/kgBW

(36) KETOPROFEN (NSAID)propionic derivative

Ketoprofen 100mg/ml

Ithasanalgesic, antipyretic,andanti inflammatoryeffect.Actsbyinhibitionof prostaglandinandLeucotrienens.It stabilizelysosomalmembrane.

Symptomaticreliefofpain, pyrexiaandinflammation ofmusculoskeletalorigin.

Cattle, Sheep,goat3mg/kg BW Dog2mg/kgBW Horse2.2mg/kgBW

Athigh concentrationit maycause irritation, bleedingor ulcerationof gastricmucosa. Avoidusagein penicillin hypersensitive animalsascross resistance between cephalosporin andpenicillinhas beenobserved.

(37) CEFALEXIN

LIXENPowder

Cephalosporininterferewithbacterialcell wallsynthesisbyinactivating transpeptidaseenzyme,producing bactericidaleffect.

AnimalsRespiratorytract infections,urinarytract infections,localized infectionsinskinandsoft tissue,mixedbacterial infections.

Dog,Cat 1030mg/kgBW TID Cattle510mg/kgBWBID

No

Name

TradeName

M.O.A

Indications

Dosage

Precautions

Shirish Bhatia

Drugs Generally Used in Clinics

(38) CEFTIOFUR (Thirdgeneration cephalosporin) BOVICEF Ceftiofursodium sterilepowder forinj. Cephalosporininterferewithbacterialcell wallsynthesisbyinactivating transpeptidaseenzyme,producing bactericidaleffect. Respiratorytractinfections, Cattle1.12.2mg/kgBWIM Avoidusagein penicillin Urinarytractprophylaxis Horse2.24.4mg/kgBWIM hypersensitive andtherapyinsurgery. Goat1.12.2mg/kgBWIM animalsascross resistance Pig35mg/kgBWIM between cephalosporin Dog2.2mg/kgBWS/C andpenicillinhas Dayoldchicks0.08 beenobserved. 0.2mg/birds/c Thesafetyof Ceftiofurhasnot Dayoldpoultry0.170.5 beendetermined mg/birds/c forhorses intendedfor breeding.

Shirish Bhatia