Physiology Cardiovascular Equations

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Cardiovascular Equations

Conduction Velocity:
A d2V
= ---- ----2RI dt2
2

= conduction velocity
A = cross-sectional area
R = resistance

I = capacitance
d2V/dt2 = second derivative
of membrane voltage to time

P = pressure
H = wall thickness

T = wall tension
r = chamber radius

Law of Laplace:
2HT
P = -----r
Stroke Work:
1
SW = stroke work
2
SW = (Pafterload)(SV) + --- mv Pafterload = afterload pressure
2
mv2/2 = kinetic energy
SV = stroke volume
SW = (MAP)(SV)
MAP = mean arterial pressure
Efficiency:
SW
CE = ------QO2

CE = cardiac efficiency
SW = stroke work
QO2 = oxygen consumption

Cardiac Output:
CO = HR (EDV ESV)
CO = (HR)(SV)

CO = cardiac output
HR = heart rate
EDV = end diastolic volume
ESV = end systolic volume
SV = stroke volume

Ejection Fraction:
EF = (EDV ESV)/EDV

EF = ejection fraction
ESV = end systolic volume
EDV = end diastolic volume

Flow through a tube:


VF = vA

VF = volumetric flow
v = velocity
A = cross-sectional area

Darcys Law:
MAP
CO = ---------TPR

CO = cardiac output
MAP = mean arterial pressure
TPR = total peripheral resistance

Poiseuilles Law:
8l
R = -------r4

R = resistance
= viscosity
l = tube length

r = tube radius

Reynolds Number:
vD
NRe = --------

NRe = Reynolds number


v = fluid velocity
D = tube diameter

= density
= viscosity

Vascular Compliance:
C = compliance
V = volume
P = pressure

C = V/P
Organ Blood Flow:
P
Qi = ------Ri

Qi = volumetric flow to organ i


P = perfusion pressure
Ri = resistance to organ i

Solute Exchange:
JS = PSS (CC-CI)

JS = solute flux
CC = [solute] in capillary
PS = permeability coefficient CI = [solute] in interstitium
S = capillary surface area for exchange

Starling Equation:
JF = LPS [(PC-PT)- (C-T)]

JF = transcapillary flux
LP = hydraulic conductivity
= plasma protein reflection coefficient
S = capillary surface area for exchange
PC = capillary hydrostatic pressure
PT = tissue hydrostatic pressure
C = capillary oncotic pressure
T = tissue oncotic pressure

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