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Glomerulonephritis: - Cherelle Fitzclarence - August 2009

Glomerulonephritis is inflammation of the glomeruli, the small round clusters of blood vessels in the kidneys. The document provides an overview of glomerulonephritis and compares micrographs of a normal glomerulus to one affected by membranoproliferative glomerulonephritis, which shows changes like increased cellularity, mesangial expansion, narrowed capillary lumens, and thickened capillary walls.

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67 views5 pages

Glomerulonephritis: - Cherelle Fitzclarence - August 2009

Glomerulonephritis is inflammation of the glomeruli, the small round clusters of blood vessels in the kidneys. The document provides an overview of glomerulonephritis and compares micrographs of a normal glomerulus to one affected by membranoproliferative glomerulonephritis, which shows changes like increased cellularity, mesangial expansion, narrowed capillary lumens, and thickened capillary walls.

Uploaded by

Fera Susanti
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Glomerulonephritis

Cherelle Fitzclarence
August 2009

Plan
General over view
Bit of revision re anatomy

Glomerulonephritis

Nephros kidney
-itis inflammation of
Glomus small round ball or knot
Pathos suffering or disease
-osis diseased condition

Glomerulonephritis inflammation of the


glomeruli
Glomerulopathy disease of the glomeruli

Light micrograph of a normal glomerulus. There are only 1 or 2 cells per capillary tuft, the capillary
lumens are open, the thickness of the glomerular capillary wall (long arrow) is similar to that of the
tubular basement membranes (short arrow), and the mesangial cells and mesangial matrix are
located in the central or stalk regions of the tuft (arrows). Courtesy of Helmut G Rennke .

Light micrograph in membranoproliferative glomerulonephritis showing a lobular appearance of the glomerular tuft with
focal areas of increased glomerular cellularity (large arrows), mesangial expansion (*), narrowing of the capillary
lumens, and diffuse thickening of the glomerular capillary walls (small arrows). Courtesy of Helmut Rennke, MD.

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