Rheumatoid Arthritis
Rheumatoid Arthritis
Rheumatoid Arthritis
What is RA?
A Chronic,
systemic inflammatory disease,
characterised by symmetrical
joint involvement which is
typically erosive/destructive.
hallmark feature: persistent
symmetric polyarthritis (synovitis)
Recap on the anatomy and physiology
Function of JOINTS:
•Unknown
• Genetic
• Autoimmune
Pathophysiology
Antigen –
Environmental agent, infectious agent
Genetic
Susceptibility Activates CD4 helper
HLA-DR4 T cells and probably
HLA-DQ B lymphocytes
HLA- DP
Cytokines
T cells stimulates
Activates
synovial macrophage
B lymphocytes
and fibroblast
Pathophysiology
T cells stimulates Activates B lymphocytes
synovial macrophage
and fibroblast
Formation of
rheumatoid
RANKL factor
Cytokines
Activates Formation of
osteoclast autoimmune complexes
Fibroblast and probable deposition
Chondrocytes in the joint
Synovial cells
Proliferation
1 hour
2. Arthritis of 3 or more joint areas.
3. Arthritis of the hand joints
4. Symetric arthritis
5. Rheumatoid nodules over extensor
surface or bony prominences.
6. Serum rheumatoid factor.
7. Radiologic changes.
Types of JIA
• oligoarticular JIA
•Polyarticular JIA
•Systemic JIA
Nursing Diagnosis: