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    Drug Study

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    karen_romero_10
    Aminoglycosides irreversibly bind to specific 30Ssubunit proteins and 16S rRNA. Gentamicin binds to four nucleotides of the 16S subunit proteins and one amino acid in protein S12. Patients with edema or ascites may have lower peak concentrations due to expanded extracellular fluid volume.

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    Drug Study

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    karen_romero_10
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    Aminoglycosides irreversibly bind to specific 30Ssubunit proteins and 16S rRNA. Gentamicin binds to four nucleotides of the 16S subunit proteins and one amino acid in protein S12. Patients with edema or ascites may have lower peak concentrations due to expanded extracellular fluid volume.

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    Aminoglycosides irreversibly bind to specific 30Ssubunit proteins and 16S rRNA. Gentamicin binds to four nucleotides of the 16S subunit proteins and one amino acid in protein S12. Patients with edema or ascites may have lower peak concentrations due to expanded extracellular fluid volume.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    21 views1 page

    Drug Study

    Uploaded by

    karen_romero_10
    Aminoglycosides irreversibly bind to specific 30Ssubunit proteins and 16S rRNA. Gentamicin binds to four nucleotides of the 16S subunit proteins and one amino acid in protein S12. Patients with edema or ascites may have lower peak concentrations due to expanded extracellular fluid volume.

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    Download as DOC, PDF, TXT or read online from Scribd
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    Drugs

    Indication

    Action

    Side Effect/ Adverse Reaction An allergic reaction: (shortness of breath; closing of the throat; hives; swelling of the lips, face, or tongue; rash; or fainting); little or no urine; decreased hearing or ringing in the ears; dizziness, clumsiness, or unsteadiness; numbness, skin tingling, muscle twitching, or seizures; or severe watery diarrhea and abdominal cramps.

    Nursing Consideratio n Give by IM route if at all possible; give by deep IM injection. Culture infected area before therapy. Use2 mg/mL intrathecal preparation without preservatives, for intrathecal use. Avoid longterm therapies because of increased risk of toxicities. Reduction in dose may be clinically indicated. Patients with edema or ascites may have lower peak concentrations due to expanded extracellular fluid volume

    Patient Teachi ngs

    Date Ordered: 07/03/2011 Generic Name: Gentamicin Brand Name: Alcomicin Apogen Bristagen G-Mycin G-Myticin Garamycin Garamycin Classification: aminoglycoside antibiotic Dosage: CHILDREN: (112 Years) 2 mg/kg every 8 hours. INFANTS: (Birth-12 months) 3 mg/kg every 12 hours

    For treatment of serious infections caused by susceptible strains of the following microorganisms: P. aeruginosa, Proteus species (indolepositive and indolenegative), E. coli, KlebsiellaEnterobactorSerratia species, Citrobacter species and Staphylococcus species (coagulasepositive and coagulase-negative).

    Aminoglycosides irreversibly bind to specific 30Ssubunit proteins and 16S rRNA. Specifically, gentamicin binds to four nucleotides of the 16S rRNA and one amino acid in protein S12. This interferes with decoding near nucleotide 1400 in 16S rRNA of the 30S subunit, interfering with the formation of an initiation complex, causing misreading of mRNA so that incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.

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