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    Estimation of Serum Urea

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    jochenzebisch
    This document provides information on estimating serum urea levels including: 1. Urea is formed in the liver from protein catabolism and its level in blood serum depends on production and excretion by the kidneys. 2. High serum urea can indicate kidney failure or increased tissue breakdown while low levels may be seen in pregnancy, liver disease or malnutrition. 3. The objective is to estimate urea concentration in serum and gain experience using testing kits.

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    Estimation of Serum Urea

    Uploaded by

    jochenzebisch
    56 views17 pages
    This document provides information on estimating serum urea levels including: 1. Urea is formed in the liver from protein catabolism and its level in blood serum depends on production and excretion by the kidneys. 2. High serum urea can indicate kidney failure or increased tissue breakdown while low levels may be seen in pregnancy, liver disease or malnutrition. 3. The objective is to estimate urea concentration in serum and gain experience using testing kits.

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    Estimation of Serum Urea (1)

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    This document provides information on estimating serum urea levels including: 1. Urea is formed in the liver from protein catabolism and its level in blood serum depends on production and excretion by the kidneys. 2. High serum urea can indicate kidney failure or increased tissue breakdown while low levels may be seen in pregnancy, liver disease or malnutrition. 3. The objective is to estimate urea concentration in serum and gain experience using testing kits.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    56 views17 pages

    Estimation of Serum Urea

    Uploaded by

    jochenzebisch
    This document provides information on estimating serum urea levels including: 1. Urea is formed in the liver from protein catabolism and its level in blood serum depends on production and excretion by the kidneys. 2. High serum urea can indicate kidney failure or increased tissue breakdown while low levels may be seen in pregnancy, liver disease or malnutrition. 3. The objective is to estimate urea concentration in serum and gain experience using testing kits.

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    Estimation of Serum Urea

    Haematology lab
    Miss. Tahani Al Shehri

    Objective
    1. To estimate the concentration of urea in serum 2. To obtain experience in the use of kits

    Introducton

    Introducton

    Urea is nitrogen compound , formed almost solely in the liver From the catabolism of amino acids and is the main excretion product of protein metabolism

    Introducton
    The concentration of urea in the blood serum represent mainly a balance between urea formation from protein catabolism and urea excretion by kidney .

    Introducton
    If kidney fail , blood urea Conc. Increase to high level and toxic condition known as (Uremia ) will result . In uremia , urea must be removed from the blood by clinical procedure called Blood Dialysis

    Introducton

    Blood Urea Nitrogen (BUN)


    Some time used as measurement of serum urea

    Mwt of Urea is Nitrogen Normal range Serum urea ( 10-50 ) mg/dl BUN ( 5- 25) mg/dl

    Clinical calculator
    http://www.clinicalculator.com/homepage.htm

    Clinical calculator

    Serum urea normally vary depending on :


    Age ( due to change kidney function ) Sex ( conc. are slightly higher in men ) Diet ( protein diet Urea )

    Abnormal condition
    Causes of high Serum urea 1. tissue protein catabolism (-ve N balance) This occurs in : Fevers Wasting disease Thyrotoxicosis Diabetic coma After trauma or a major operation

    Abnormal condition
    2. Excess breakdown of blood protein

    Leukemia Release of leukocyte protein

    GIT Bleeding Hb & plasma protein can be released in to the gut

    Abnormal condition
    3. Diminished excretion of urea

    Pre-renal
    Eg, -Shock -congestive heart failure -Sodium depletion -Addisons disease

    Renal disease
    Eg, Acute Glomerulonephritis Chronic heart failure Sever destructive renal disease Acute renal failure Hepatorenal syndrom

    Post-renal
    Eg, -Enlarge prostate Gland -Stone

    Azotemia :- Is a term used for a high blood serum urea concentration Uraemia :- ( as opposed to Azotemia) Is the name given to the clinical syndrom that develops when there is nitrogen retention due to renal failure

    Low Serum urea


    1.Late pregnancy Due to : glomerluar filtration rate (GFR) Use of N by fetus Water retention 2. Liver disease 3.long term of protein malnutrition Increase rate of protein anabolism Long term replacement of blood loss with intravenous dextran or glucose or saline (Dilution )

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