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    Structure of Skeletal Muscle

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    nirilib
    The document summarizes the structure of skeletal muscle in three paragraphs. It describes the structure from the macroscopic level down to the microscopic and ultrastructural levels. Key points include that skeletal muscle forms 40% of body weight, is striated and multinucleated. At the microscopic level it has dark A bands and light I bands. At the ultrastructural level it contains thick myosin filaments that form cross bridges with thin actin filaments, regulated by tropomyosin and troponin.

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    Structure of Skeletal Muscle

    Uploaded by

    nirilib
    352 views13 pages
    The document summarizes the structure of skeletal muscle in three paragraphs. It describes the structure from the macroscopic level down to the microscopic and ultrastructural levels. Key points include that skeletal muscle forms 40% of body weight, is striated and multinucleated. At the microscopic level it has dark A bands and light I bands. At the ultrastructural level it contains thick myosin filaments that form cross bridges with thin actin filaments, regulated by tropomyosin and troponin.

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    structure of skeletal muscle

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    The document summarizes the structure of skeletal muscle in three paragraphs. It describes the structure from the macroscopic level down to the microscopic and ultrastructural levels. Key points include that skeletal muscle forms 40% of body weight, is striated and multinucleated. At the microscopic level it has dark A bands and light I bands. At the ultrastructural level it contains thick myosin filaments that form cross bridges with thin actin filaments, regulated by tropomyosin and troponin.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    352 views13 pages

    Structure of Skeletal Muscle

    Uploaded by

    nirilib
    The document summarizes the structure of skeletal muscle in three paragraphs. It describes the structure from the macroscopic level down to the microscopic and ultrastructural levels. Key points include that skeletal muscle forms 40% of body weight, is striated and multinucleated. At the microscopic level it has dark A bands and light I bands. At the ultrastructural level it contains thick myosin filaments that form cross bridges with thin actin filaments, regulated by tropomyosin and troponin.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    of 13

    Dr.

    Niranjan Murthy H L
    Asst. Prof., Dept. of Physiology
    Sree Siddhartha Medical College & Hospital, Tumkur
    STRUCTURE OF SKELETAL
    MUSCLE

    • Forms 40% of body weight


    • Locomotion
    • Striated or voluntary
    • Multinucleated
    Sarcolemma-
    • Consists of an inner plasma membrane and
    outer collagenous layer
    • Invaginates at numerous points to form T-
    tubules
    • Carries action potential
    Sarcoplasm-
    • Consists of myofibrils
    • Numerous mitochondriae
    lying parallel to myofibrils
    Sarcoplasmic reticulum-
    • L-tubules
    • Storage of calcium ions
    • Skeletal muscle
    • Fasciculus
    • Muscle fibers
    • Myofibrils
    • Myofilaments
    • Muscle fiber- 10 to 80μ in diameter each is
    composed of 1000s of myofibrils

    • Each myofibril is in turn made up of


    myofilaments

    • Myofilaments
    (i) contractile- myosin II, actin
    (ii) modulatory- tropomyosin, troponin
    LIGHT MICROSCOPIC STRUCTURE
    • Cross striations due to alternate dark and light bands
    • Light band- Isotropic band- I band- thin filaments
    • Dark band- Anisotropic band- A band- birefringent
    • H zone- lighter zone in A band
    • Z line- in the center of I band
    • M line- in the center of A band
    • Sarcomere- between two z lines- basic unit of muscle
    ULTRASTRUCTURE
    • Myofilaments- thick & thin filaments
    • Myosin-10 to 14nm wide & 1.6μm long
    1500 in each myofibril
    Myosin filament made of around 200molecules of myosin
    • Myosin molecule- composed of 6 polypeptide chains- 2 heavy
    chains and 4 light chains
    A tail, an arm and 2 globular heads
    Arm and head form cross-bridge
    Two hinges
    Head has sites for ATP and actin binding
    • Actin filament- 7nm wide and 1.0μm long
    Extend on both sides of z-lines
    F-actin forms a double helix
    Made of 300 G-actin molecules (MW 42,000)
    G-actin has active sites for interaction with
    myosin heads
    • Tropomyosin- 40nm length and MW of
    70,000.
    Wrapped around actin helix & covers
    active sites in resting phase

    • Troponin- made of 3 protein subunits


    (Tn I, Tn C & Tn T)
    OTHER PROTEINS

    3) Actinin- binds actin to Z lines

    2) Desmin- binds Z lines to the plasma


    membrane

    3) Titin- connects Z lines to M lines and provide


    scaffolding for sarcomere. Provides elasticity

    4) Dystrophin, dystroglycans and sarcoglycans

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