men blindfolded by turns, and then enquired of them,
if they heard the rapid motions of the Aurora. Tey
soon became sensible they did not, and yet so powerful was the Illusion of the eye on the ear, that they still believed they heard the Aurora. What is the cause that this place seems to be in the centre of the most vivid brightness and extension of the Aurora: from whence this immense extent of electric fuid, how is it formed, whither does it go. Questions without an answer. With the onset of the heroic age of British Arctic exploration in 1818, the Admiralty made it a high priority to provide answers to these questions. Te scientifc members of John Franklins Arctic land expedition of 1819-22, however, could not distinguish its rustling noise, of which, however, such strong testimony has been given to us, that no doubt can remain of the fact. On occasions they came tantalisingly close to this perception: we imagined, more than once, that we heard a rustling noise like that of autumnal leaves stirred by the wind; but after two hours of attentive listening, we were not entirely convinced of the fact. Unable to hear them, they did receive testimony of auroral sounds from a credible source. At Fort Chipewyan in 1821, a fur trader from the North West Company told them of an aurora so powerful that the Canadians fell on their faces and began praying and crying, fearing they should be killed; he himself threw away his gun and knife that they might not attract the fashes, for they were within two feet of the earth [...] and made a rustling noise, like the waving of a fag in a strong breeze. In most scientifc accounts of aurorae in the 19 th
century there was a distinct tension between describing the wondrous spectacle of the Northern Lights while disciplining the emotions and avoiding superstition. Whereas British expeditioners could not hear the Northern Lights, they continued to collect strange stories from sources they generally trusted. For example, even a prominent sceptic like Captain George Lyon could describe the air of magic during one stormy night in the Arctic and write how he had never contemplated the aurora without experiencing the most awful sensations, and can readily excuse the poor untutored Indians for supposing that in the restless motions of the Northern Lights, they beheld the spirits of their fathers roaming in freedom through the land of souls. Given that scientifc experts continued to profess profound uncertainties about the nature of aurorae up to the 1940s, why did testimony on auroral audibility not force a change in approach? Partly, this was due to the wider disciplining of the heavens that was associated with the rise of meteorology and the decline of folk weather knowledge and prognostication during the Enlightenment. But it was also because most reports came from permanent inhabitants of Arctic Canada: fur traders and indigenous inhabitants. Tinking about the Northern Lights, therefore, has historically involved assessing who is best qualifed to observe them. Tis continues to play out nowadays in conversations between seasoned feld scientists and aurora watchers who all know of someone who heard the Northern Lights. Yet, recent data from Finland has reignited the debate on whether the Northern Lights can make sounds. In 2012, researchers from Aalto University recorded a series of cracking or whipping noises during an auroral manifestation. Tese, they claimed, were formed about 70 metres above ground level (rather than in the atmosphere) and were caused in some way by the geomagnetic disturbances associated with the aurora borealis. Te researchers noted that auroral audibility was a rare phenomenon and that details about how the auroral sounds are created are still a mystery. As 2013 heralds a period of solar maximum, it behoves travellers and scientists in the Arctic to remember what the fur traders said and continue to keep their ears, as well as their eyes, open. Shane McCorristine is a Marie Curie/Irish Research Council postdoctoral fellow at NUI Maynooth and the Scott Polar Research Institute Have You Heard the Northern Lights? 7 Easter 2013 P U B L IC The aurora borealis is a natural light phenonmenon, sometimes visible at northern polar latitudes A CENTURY AFTER Gregor Mendel proposed the idea of inheritance and nearly fve decades since the structure of DNA was deduced, we have come to realise that many human diseases are linked directly to our genes. From infections to heart disease, scientists have revealed associations between many debilitating illnesses and the diferent versions of genes, known as alleles, that people carry. Understanding the genetic basis of disease has revolutionised the way we diagnose, monitor and treat illness, but it has also raised the question of whether the scientists who discovered these genes and their disease associations own their discovery, and to what extent should they be rewarded for their work. Te idea of patenting human genes is one that has been the subject of much contention and controversy. Pharmaceutical companies, as well as many academic scientists, have carried out the majority of the research into the molecular basis of disease in the hope of generating a proft from their discoveries. Scientifc research is an expensive business, and patenting can give labs fnancial security in promoting innovation and funding future projects. But, many scientists, medical professionals and non-proft organisations argue that it is unethical to charge a fee to those who seek to know if they carry a disease-causing allele, and that such information should be freely available to prevent unnecessary human sufering. Gene patenting is once again in the spotlight as the United States Supreme Court is set to rule on a lawsuit that has dominated the debate on human gene patenting and decide whether the molecular diagnostic company Myriad Genetics can patent the BRCA1 and BRCA2 (Breast cancer type 1/2 susceptibility proteins) genes, giving them the sole right to perform diagnostic tests. BRCA1 and BRCA2 were discovered and sequenced in the early nineties, from a woman with a strong family history of breast and ovarian cancer. Normally, BRCA proteins repair DNA when damage is detected. However, a small number of people have a form of the BRCA gene that is unable to reverse the DNA damage causing genetic material to accumulate within a cell leading to the development of cancer. Carrying an abnormal copy of either BRCA1 or BRCA2 increases the risk of breast and ovarian cancer development by up to 60 per cent. Te discovery of the BRCA genes was a major scientifc advance in genetics, enabling screening of high-risk women for susceptibility alleles and therefore allowing early medical intervention and ultimately saving many lives. Myriad, a company founded by one of the scientists who initially discovered BRCA, was granted a patent in 1997 and holds the rights for detecting gene mutations to diagnose cancer, as well as using the genes to identify novel drugs directly targeting the BRCA proteins. Te controversy surrounding gene patenting stems from the refusal of Myriad to licence its genes to labs wishing to use BRCAs for clinical testing. Although Myriad will allow other researchers to study the genes for free, it is the sole provider of BRCA1 and BRCA2 diagnostic testing in the US, allowing them to set a market price of around $3000 for a full analysis of the genes. Te company relies solely on the patents to generate its proft. However, its patent is due to run out in 2014 although they hope to extend it as in the US a patent has a 20 year term from the Kevin C-C Chen explores the implications of a Supreme Court ruling on BRCA cancer gene patents 8 The Myriad Genes Easter 2013 C h r is T o s
P A N A Y i d u l l h u N K The cycle path from Addenbrookes Hospital to Great Shelfold in Cambridgeshire features the BRCA2 gene sequence. The Myriad Genes fling date, but can be extended if it relates to a human or animal drug product. Te American Civil Liberties Union (ACLU), a non-proft organisation that advocates individuals rights, together with the Public Patent Foundation (PUBPAT), has challenged whether the patent should stand and have brought a lawsuit against Myriad. Te outcome of the judgement will determine the fate of genetic research and every one of us who may seek medical attention for diseases in the future. In the US, like most other countries, patenting natural law is not allowed. For example, the law of gravity can be observed anywhere in the world, and the usage of such law is not (and cannot possibly be) restricted by a simple patent. Te patent for genes is a more complicated issue. Although patent law cannot protect natural phenomena, DNA historically has been regarded as a sequence of chemicals determined by humans, and therefore not seen to be natural. Tis is because as recently as the 1990s, to sequence just one gene was considered a mammoth task. Te frst complete human genome sequence was published in 2003 at a cost of billions of dollars and joint efort across the globe. As protection for their efort and fnancial investment, many companies and academics fled patents for the genes they discovered, so they could secure the fnancial benefts the genes might bring. Tis was the case for Myriad, who beat their European competitors to patent the BRCA genes and as a result enjoyed great success through the sale of diagnostic tests. Biotech companies argue that having the patents does not just reward their hard work but also allows their labs to focus solely on mutations that might occur in the patented genes. Myriad suggested that their company studied the mutations more thoroughly before publishing them, in comparison with other laboratories that simply reported the mutation without showing how it causes cancer. Tey claimed that the company had invested in building their facility to constantly improve and maintain the quality of their testing kit. Furthermore, most biotech companies only pursue litigation for those who seek to proft, not the majority of scientists who work on the general studies of the genes. Te ACLU, however, argued that the patents have slowed the progress of understanding BRCA mutations. Although there are currently 8000 publications on the genes, according to the journal Nature, Myriad had prevented at least fve researchers from testing women directly following the studies. Moreover, a study carried out by Professor Mary- Claire King of the University of Washington, whose group was involved in the initial studies of the BRCA genes linkage with cancer, suggested that Myriads test kit, Comprehensive BRCAnalysis, did not pick up a number of mutations that are signifcant in the development of cancer. Additionally, Myriads fgures show that the company made $402 million in revenue, of which 90 per cent was directly from the test kit, in the fscal year ending June 2011. ACLU argued that Myriad has already been rewarded fnancially for the discovery of the BRCA genes. If the restriction imposed by the patent had been lifted, progress in the understanding of how diferent BRCA alleles lead to cancer could have improved signifcantly. Critics of Myriad believe that patients are losing out as a result of the patent. For many people in Europe, health care is provided freely. More importantly, the BRCA patents in Europe are held by Cancer Research UK, a charity, which ofers a diferent diagnostic kit than that from Myriad and free licensing to any reputable laboratory that wants to use it. For US citizens, however, the expensive price tag will have prevented many from accessing the test for BRCA alleles and any early disease intervention. More worryingly, Myriads own testing has suggested that for Latino women, an entire 20 per cent of all mutations can only be detected by its supplementary test, costing an additional $700 and not covered by many insurers in the US. Since 2009, the journal Nature has been following the progress of the lawsuit between Myriad and ACLU. In March 2012, the federal court ruled in Myriads favour. Te Supreme Court then requested the court to reconsider, but in August the court ruled in Myriads favour once more. Since then, ACLU and the PUBPAT have asked the Supreme Court to reconsider certain aspects of the case. On 30 th
November 2012, the court decided to answer the question of whether the human genes are patentable. Te ruling is expected later this year. Whatever the decision, the Supreme Court will not just be deciding on the fate of one biotech company, it will be deciding on the future of gene patenting, and the implication it has for patients around the world and the scientifc community as a whole. Kevin C-C Chen is a 2 nd year PhD student at the Department of Medicine The Myriad Genes 9 Easter 2013 M iK E
M iT C h E l l Purifed dNA, fuorescing orange under UV light, can be isolated and used for sequencing. IM DOING A FREE operating system (just a hobby, wont be big and professional)... announced a young Finnish PhD student to an internet message board on the 25 th of August 1991. In the two decades since Linus Torvalds made this announcement, what started as a small and amateur operating system has revolutionised the IT world. Linux, as it is known, now runs over 60 per cent of the worlds internet servers, powers over 90 per cent of the worlds supercomputers and holds a signifcant share of the smartphone market through Android. At the time of Linuxs conception there were several similar projects developing experimental operating systems for research purposeseither to directly research operating system design or as a platform for other research. However, Linux stood out from the crowd because it was made open-source. Tis means that as well as being given a copy of the compiled machine code that the computer understands, users are also given the human readable source code that they are free to modify and improve. Tese modifcations are then submitted back to maintainers who test the changes and incorporate them into the ofcial release. Tis model is very similar to the one used by projects such as Wikipedia, where anyone is free to edit and improve the content. Torvalds found that this model for software development worked very wella community of academics from other universities throughout the world could freely collaborate on his project through the internet. In particular, this meant that each contributor could work on the particular area that most interested them, and in which they were most highly skilled. People worked on Linux because they enjoyed doing so and because improving Linux would beneft their own work and the work of others across the globe. Another pioneer of the open-source movement is Richard Stallman, the founder of the Free Software Foundation, the FSF. Although Stallman shared Torvalds opinions as to the pragmatic benefts of the open-source development model, he had his own more philosophical reasons for despising the classical closed source development model. In the early 1980s, Stallman worked at MITs Artifcial Intelligence Lab, where something of a hacker culture existed. In its true meaning, hacking is the digital equivalent of the car enthusiast tinkering with their engine to improve performance, so this wasnt hacking in the popular sense, but was more about having a thorough understanding of a system in order to improve it. Tis geek culture was challenged when in 1980 the lab upgraded to the top-of-the-range Xerox 9700, the frst commercially available laser printer and a technological breakthrough according to the manufacturer. However, the new printer proved to be a step backwards as far as the MIT lab was concerned. In an efort to improve the usability of their previous printer, the group had modifed it so that it would message the job owner when their print job was done or if an error had occurred. However, Xerox refused to make the source code available for the new printer, believing that doing so would put their intellectual property at risk. Tis made it impossible to edit the software of Xerox products and efectively made the process of technological development a sealed box. Stallman was infuriated. He felt that as the owner, he should be able to do whatever he pleased with the printer, including modifying its source code. So, in 1984 he initiated the GNU project to develop an operating system that would put its end users in control, allowing them to modify their system as they pleased. Although the GNU project itself has not released a fully working operating system, its freely available suite of utility programs can be combined with the Linux kernel, the central core of the 10 Open for Everyone Easter 2013 Haydn King describes the open-source software movement and two of its most striking characters Linus Torvalds is the creator of what has become one of the most important computer operating systems
L in u x m a g .c O m Ja m E s
c O n a n
B a K E r Open for Everyone operating system, to create what is often referred to as GNU-Linux, or just Linux. In a video to mark the 25 th anniversary of the GNU project in 2009, Stephen Fry publicly supported the project, saying why cant the community at large alter and improve [an operating system] and share it, thats how science works after allall knowledge is free and all knowledge is shared in good science. If it isnt, then its bad science and its a kind of tyranny. So, how did a loosely knit group of academics with lofty ideals put together an operating system in their spare time to rival that of Microsoft and Apple? Linuxs decentralised and ad-hoc methodology made contributing to the project straightforward and allowed each part of the system to be written by an expert. But even this cannot explain how such an outft has won 60 per cent of the server market given the vast resources of its competitors. Te truth is that Linux is no longer only worked on by academics in their free time. Although Linux continues to rely upon the work of its community of users, over 70 per cent of the work is now carried out by paid developers. Some of these developers are paid by hardware giants such as Intel who see that the improvements made to Linux software will in turn improve the operation of their products and services, which rely on the Linux operating system. Other companies that pay their workers to improve the Linux operating system include Red Hat and Novell, both of which make money by selling accredited Linux distributions and support contracts. Tis may seem strange; why would anyone be willing to pay for something they can get for free? Furthermore, neither company is allowed to keep any of their modifcations secret. Tis means that they are essentially selling exactly the same thing as can be obtained from any of several entirely free distributions. When asked why companies come to him and pay for what they could get for free, Red Hat co- founder Bob Young likened the question to one about ketchup: Ketchup is nothing more than favoured tomato paste. Something that looks a lot like Heinz ketchup can be made in your kitchen sink without so much as bending a copyright rule... so why dont we, as consumers, make ketchup in our kitchen sink? Te answer is obvious: it is cheaper and more convenient to buy ketchup from the local Sainsburys than to make it yourself, in the same way as it is cheaper to pay Red Had or Novel to fne-comb and provide technical support for Linux distributions. Reliability is key when companies and organisations buy software, and you cannot guarantee the security of a piece of software unless you can see exactly how it works. NASA even have an expression that says: software is not software without the source code. However, despite numerous attempts, Linux has never broken into the mainstream PC market. Tere are several reasons for this. Linux still struggles with its image of being too complicated and difcult for the average user, even though user-friendly distributions such as Ubuntu are as simple to use as the alternatives in most cases. Competitors have been able to establish complete dominance by using aggressive marketing techniques such that even with our current competition laws, buying a new PC without also having to buy a Windows licence is practically impossible. An area in which Linux has been gaining ground quickly in recent years is in the software that is available on it. While Linux itself is still the largest single open-source software project, there are a number of other projects that have thrived under the open-source model. Te Mozilla Firefox and Google Chrome internet browsers now have nearly 80 per cent of the browser market share between them, and both are entirely open-source and cross-platform projects. An entire ecosystem of applications has been built using the model, from ofce suites such as LibreOfce to music players like Amarok, many of which are also available on multiple platforms besides Linux. Just as the free software movement is bigger than Linux, the open-source ideals extend beyond software. From the ideas of Stallman and his contemporaries came the notion of the copyleft licence, the most famous of which are the Creative Commons licences. Tese licences can be applied not just to software, but to all forms of creativity writing, media, art and scientifc worksand allow authors to share their work with others, who can build on it without fear of copyright infringement. Open-source focuses on making applications as good as they possibly can be rather than on selling as many units as possible, and so the software produced is often far more fexible than closed alternatives. Tat is the open-source ethos. Haydn King is a 4 th year undergraduate at the Department of Engineering Easter 2013 Linux-based operating systems are used to run most of the worlds supercomputers, such as Blue Gene/P a r g O n n E
n a T iO n a L
L a B O r a T O r y B E a T r ic E
m u r c
H richard stallman, promoter of the free software movement. and founder of the Free Software Foundation 2013 marks the 100 th anniversary of the Medical Research Council (MRC). Many have heard of this iconic institution, but few might realise the impact its research has had on our daily lives. Tis year, the MRC will be opening its doors to members of the public to reveal some of the life-changing research programmes that it funds. An emphasis on collaboration is a running theme, with many of their most recent discoveries being carried out in collaboration with the Welcome Trust, Cancer Research UK, or with one of the many other funding bodies in the UK. But it hasnt always been this way. Te MRC grew out of the Royal Commission to research the most pressing medical problem in the UK in the early 20 th century: Tuberculosis. Funds came from the 1911 National Insurance Act. Te money was to be spent on research carried out by investigators in approved institutions, the frst science institutes in the UK. Te frst of these continues today in North London as the National Institute of Medical Research. In 1913, 100 years ago, the Medical Research Committee and Advisory Council was established. Tis was the single research organisation for the UK, developing and funding their own research programmes and providing funding for research by other individuals or institutions that complemented their own. Today, the MRC is a non-departmental public body funded through the governments science and research budget. Tere are 56 MRC units, centres and institutes across the UK and in Africa. Te MRC supports research in all areas of medicine. Last year alone, the MRC funded 1,100 grants totalling over 309.9 million. In Cambridge, the MRC is currently committed to awards totalling over 130 million. It provides around 700 jobs in Cambridge at the MRC Laboratory of Molecular Biology and its other units and many more through the grants held in the University of Cambridge, and other local research institutes. Te MRC has a long history in Cambridge. In 1944, the MRC set up the Applied Psychology Research unit with Cambridge Universitys Department of Psychology. Te unit made advances in the feld of service personnel research, such as the selection of aircrews, pilot fatigue and the design of aircraft controls and instruments. After the war it made a number of major contributions to our understanding of such psychological processes as attention and memory and continued to tackle practical problems. For example, the unit was responsible for the heptagonal shape of our 20p and 50p coins. Research into the lives of the blind or partially sighted revealed that a range of entirely circular coins were incredibly difcult to tell apart by touch, leading to much frustration for the partially sighted. Te introduction of the heptagonal coins removed much of the difculty, as each British coin is now distinctively diferent to both sight and touch. In due course, it was renamed the the MRC Cognition and Brain Sciences Unit. Tis more modern counterpart is engaged in active collaborations with many other research institutes, and uses a range of brain imaging techniques. Other major contributions in Cambridge by MRC units over the years span such felds as nutrition, protein engineering and cancer, covering topics 12 Commemorating a Commission Easter 2013 Felicity Davies celebrates the centenary of the Medical Research Council James Watson (middle) and Francis Crick (right) discovered the structure of DNA in what is now called the MRC Laboratory of Molecular Biology M a r Jo r ie
M C C a r t y Commemorating a Commission J o s e p h i n e
B i r C h the heptagonal shape of our 20p and 50p coins was introduced to make the coins more deistinguishable Jo h n W o B e r t as diverse as the biology of mitochondria, and the contribution of genes and lifestyle to the incidence of diabetes across Europe. One of the most exciting breakthroughs was the discovery of the helical structure of DNA by Watson and Crick in 1953 in what is now called the MRC Laboratory of Molecular Biology (LMB). With the invention of DNA sequencing techniques by Fred Sanger, also at the LMB, the stage was set for the human genome project, with the Cambridge contribution led by John Sulston who moved from the LMB to found the Wellcome Trust supported Sanger Institute, where much of the UK efort was undertaken. To coincide with the centenary, change is happening for the MRC. In Cambridge, the new building for the LMB is complete, and research groups have been moving in since February 2013. Te previous building was opened by the MRC in 1962, and was home to 9 Nobel Prizes, shared between 13 scientists at the LMB. As a result, the institute was nicknamed Te Nobel Prize Factory. Te new building is the fagship building for the extension of the Cambridge Biomedical Campus and the MRC hopes that it will continue to provide frst class facilities to some of the worlds leading scientists. Te laboratory will have cost 212 million, and will provide space for more than 400 researchers. Te overall structure of the new building is evocative of paired chromosomes, with two long laboratory areas joined by a large entrance hall, containing seminar rooms and a lecture theatre. In keeping with the concept of partnership, the University have contributed towards the cost of the building, which will also house several University research groups. Some may argue that not much has changed since the Royal Commission; the aim of the MRC remains frst and foremost the furthering of medical knowledge and understanding through scientifc research. Te biggest change in the last 100 years has been an increase in collaborations between research bodies. Te MRC was founded as the frst research body of its kind, but today, there is a wealth of research funding institutions, including sister research councils to the MRC. In Cambridge, the MRC works very closely with Cancer Research UK, the British Heart Foundation and the Wellcome Trust. Adrian Penrose, Regional Communications Manager for Cambridge and the Midlands has described it as a catalytic coming together of scientifc expertise. With the complexity of the research questions to be addressed, and the need to bring together scientists from across the biological, physical and social sciences, collaborations have become invaluable. Expertise and experience are now found in a wide range of locations, and it is only by pooling knowledge and fnancial resources that research can be done efectively. Te MRCs centenary year will be a way of emphasising these collaborations. As it moves into its next 100 years, the MRC is embarked in a new form of collaboration, the university units, to strengthen the ties between the MRC and their academic research colleagues. As well as collaborations with universities, the MRC is also developing more collaborations with industry. Te latter has had less money to spend on research, which has spurred on partnerships between industry and research bodies. Tis is particularly the case in the feld of pharmacology, not least as a number of the expensive drugs are starting to come of patent. Late in 2012, the MRC announced a deal with AstraZeneca, a large UK pharmaceutical company. Te company agreed to allow scientists access to certain compounds that did not go all of the way to becoming patented drugs. Tese compounds might nevertheless be useful for a diferent research area. Access to data from the pharmaceutical industry can, if shared, save valuable time and money, and allow scientists to make new discoveries. Te centenary year will be used by the MRC to extend their reach to a wider community. Te MRC units regularly take part in the Cambridge Science Festival, and in June they will open their doors in the frst MRC open week. More than 40 units and centres will be open to the public, some for the frst time, so that members of the public can see for themselves the work carried out by the MRC.
Felicity Davies is an MPhil student at the Faculty of Philosophy Easter 2013 D a v iD - p - h o W a r D the new building for the MRC Laboratory of Molecular Biology was completed in 2013 RECENTLY, A DEAD carrier pigeon with a secret message from World War II was found during renovation of the chimney of a house in Surrey. It is believed that the message was sent from Nazi- occupied Normandy in June 1944. Te encrypted message has been sent to the UK Government Communications Headquarters to be deciphered, so far without success. Te amount of press surrounding this incident is uncommon for a subjects that usually stays out of the limelight: cryptography. Te purpose of cryptography is to alter a message in such a way that it makes no sense to anyone except for the intended recipient. In the past it was only used by governments and the military, but nowadays everyone who surfs the internet uses it, whether they know it or not. Cryptography started with simple methods: Caesar is known to have used an encryption in which each letter of the alphabet is shifted by a fxed distance (for example, message turns into nfttbhf by replacing each letter by its successor). Te distance by which the letters are shifted is called the key. If the recipient knows the key, then he can easily decipher the message. Te idea is that anyone who doesnt have access to the key has no chance of understanding the coded text. However, Caesars code could be easily broken if his enemy knew the method of encryption. For this reason it was necessary to invent more complex codes to ensure the security of the message. Tis was the beginning of the battle between friends and enemies, governments and criminals, code makers and code breakers. By World War II, the encryption techniques had developed signifcantly. Te Germans enciphered their messages with a mechanical coding machine called Enigma, which they thought was unbreakable. But some machines and encryption keys fell into the hands of the British forces, and so British military intelligence, frst and foremost Alan Turing, were able to decipher the code and thus change the course of the war. Teir efort drove the development of the frst programmable electronic computer, the Colossus. Tere is a method of encoding messages that is provably unbreakable: it uses a random sequence of numbers (the key) to turn the message into a string of letters which looks entirely random. Decoding the message is easy for the recipient who has access to the key, but it is impossible for anyone who doesnt know it. Each key can only be used oncehence the name: one-time pad. However, the one-time pad isnt widely used. Te problem that this method shares with all other encryption techniques developed before the 1970s is the distribution of keys. It was thought that encryption and decryption is a symmetric process: that the same key is needed to encrypt a message and to reverse the encryption. For this to work, both the sender and the recipient of the message have to be in possession of the same key. But as the Germans experienced in World War II, this is a risky business; keys can be lost by accident, corruption, or blackmail. A breakthrough came with the inception of public key cryptography. Before its invention, enciphering a text was essentially a mechanical procedure designed to muddle up the letters. However, using mathematical techniques, it is possible to design codes that are asymmetric. Every person has a pair of keys, a private key and a public key. Te private key is kept secret and the public key is made available to everyone. If two people, Alice and Bill, want to have a secure conversation, they dont have to meet in order to agree on a key. Alice just sends a message to Bill by encrypting it with Bills public key, and Bill uses his private key to decrypt it. Te asymmetry of the mathematics working in the background ensures that the message cannot be decoded except with Bills secret private key. Te asymmetry behind public key cryptography is obtained by mathematical operations whose computation is easy in one direction, but very time-consuming in the other. For instance, the RSA algorithm, named after its inventers Ron Rivest, 14 Cracking Codes Easter 2013 Philipp Kleppmann deciphers the advance of cryptography throughout the centuries D a n ie l
K u P e r m a n enigma, the machine used by the Germans to encipher messages Cracking Codes e m il y
The Neanderthals Are Back: The Beginning: A Series of Stories about Modern Day Neanderthals and their New Families After Two Scientists Bring Them Back