Aasld Practice Guidelines Management of Adult Patients With Ascites Due To Cirrhosis: An Update

AASLD PRACTICE GUIDELINES
Management of Adult Patients with Ascites Due to

Cirrhosis: An Update
Bruce A. Runyon
Preamble
This guideline has been approved by the AASLD and
represents the position of the Association. These recom-
mendations provide a data-supported approach. They are
based on the following: (1) formal review and analysis of
the recently-published world literature on the topic
(Medline search); (2) American College of Physicians
Manual for Assessing Health Practices and Designing
Practice Guidelines
1
; (3) guideline policies, including the
AASLD Policy on the Development and Use of Practice
Guidelines and the American Gastroenterological Associ-
ation Policy Statement on Guidelines
2
; and (4) the au-
thors decades of experience caring for patients with
cirrhosis and ascites.
Intended for use by physicians, these recommenda-
tions suggest preferred approaches to the diagnostic, ther-
apeutic, and preventive aspects of care. They are intended
to be exible, in contrast to standards of care, which are
inexible policies to be followed in every case. Specic
recommendations are based on relevant published infor-
mation. To more fully characterize the quality of evidence
supporting recommendations, the Practice Guidelines
Committee of the AASLD requires a Class (reecting
benet versus risk) and Level (assessing strength or cer-
tainty) of Evidence to be assigned and reported with each
recommendation (Table 1, adapted from the American
College of Cardiology and the American Heart Associa-
tion Practice Guidelines
3
).
4
These guidelines were developed for the care of adult
patients with clinically detectable ascites. Although the
general approach may be applicable to children, the pedi-
atric database is much smaller and there may be unantic-
ipated differences between adults and children. Patients
with ascites detected only by imaging modalities but not
yet clinically evident are excluded because of the lack of
published information regarding the natural history of
this entity.
A Medline search from 1966 through 2007 was per-
formed; search terms included ascites, hepatorenal syn-
drome, diet therapy, drug therapy, radiotherapy, surgery,
and therapy. The search involved only articles published
in English and involving humans. A manual search of the
authors les and recent abstracts was also performed. The
search yielded 2115 articles including 153 published since
a similar search was performed in 2002 in preparation for
writing the previous guideline on ascites.
Introduction
Cirrhosis was the twelfth leading cause of death in the
United States, according to a 2006 Vital Statistics Report
in which data were collected through 2004.
5
Ascites is the
most common of the three major complications of cirrho-
sis; the other complications are hepatic encephalopathy
and variceal hemorrhage.
6
Approximately 50% of pa-
tients with compensated cirrhosis, i.e., without having
developed one of these complications, develop ascites
during 10 years of observation.
6
Ascites is the most com-
mon complication of cirrhosis that leads to hospital ad-
mission.
7
The pathophysiology of ascites and hepatorenal
syndrome have been reviewed elsewhere.
8
Development
of uid retention in the setting of cirrhosis is an important
landmark in the natural history of chronic liver disease:
approximately 15% of patients with ascites succumb in 1
year and 44% succumb in 5 years.
9
Many patients are
referred for liver transplantation after development of as-
cites.
Evaluation and Diagnosis
History
Most patients (approximately 85%) with ascites in the
United States have cirrhosis (Table 2).
10
In about 15% of
Abbreviations: AASLD, American Association for the Study of Liver Diseases;
LDH, lactate dehydrogenase; PMN, polymorphonuclear leukocyte; SAAG, serum-
ascites albumin gradient; SBP, spontaneous bacterial peritonitis; TIPS, transjugu-
lar intrahepatic portasystemic stent-shunt.
From the Liver Service, Loma Linda University Medical Center, Loma Linda,
CA.
Received January 15, 2009; accepted January 16, 2009.
Address reprint requests to: Bruce A. Runyon, M.D., Chief, Liver Service, Loma
Linda University Medical Center, 11234 Anderson Street, Room 1556, Loma
Linda, CA 92354. E-mail: brunyon@llu.edu; fax: 909-558-0274.
All American Association for the Study of Liver Diseases (AASLD) Practice
Guidelines are updated annually. If you are viewing a Practice Guideline that is
more than 12 months old, please visit www.aasld.org for an update in the material.
This is a revised and updated guideline based on the previously published
version. (HEPATOLOGY 2004;39:841-856).
Copyright 2009 by the American Association for the Study of Liver Diseases.
Published online in Wiley InterScience (www.interscience.wiley.com).
DOI 10.1002/hep.22853
Potential conict of interest: Dr. Runyon is a consultant for Novashunt.
2087
patients with ascites, there is a nonhepatic cause of uid
retention. Successful treatment is dependent on an accu-
rate diagnosis of the cause of ascites; e.g., peritoneal car-
cinomatosis does not respond to diuretic therapy. Patients
with ascites should be questioned about risk factors for
liver disease. Those who lack an apparent cause for cirrho-
sis should also be questioned about lifetime body weight;
nonalcoholic steatohepatitis has been concluded to be
causative in many of these patients.
11
Past history of can-
cer, heart failure, renal disease, or tuberculosis is also rel-
evant. Hemophagocytic syndrome can masquerade as
cirrhosis with ascites.
12
These patients have fever, jaun-
dice, and hepatosplenomegaly, usually in the setting of
lymphoma or leukemia.
12
Physical Examination
The presence of a full, bulging abdomen should lead to
percussion of the anks. If the amount of ank dullness is
greater than usual (i.e., if the percussed tympany-dullness
interface is higher than normally found on the lateral
aspect of the abdomen with the patient supine), one
should test for shifting. The presence of shifting dull-
ness has 83% sensitivity and 56% specicity in detecting
ascites.
13
Approximately 1500 mL of uid must be
present before ank dullness is detected.
13
If no ank
dullness is present, the patient has less than a 10% chance
of having ascites.
13
The uid wave and puddle sign are
cumbersome and perform less well when compared to
shifting dullness.
13
Ascites due to alcoholic cardiomyop-
athy can mimic that due to alcoholic cirrhosis. Jugular
venous distension is present in the former but not in the
latter. Also measurement of a blood concentration of
brain natriuretic peptide or probrain natriuretic peptide
can help distinguish ascites due to heart failure from as-
cites due to cirrhosis.
14
The median probrain natriuretic
peptide concentration is 6100 pg/mL in the former and
only 166 pg/mL in the latter.
14
Giant cysts or pseudocysts can rarely mimic ascites.
Paracentesis may produce uid with unusual characteris-
tics. Imaging usually provides the correct diagnosis.
15
The physical examination for detecting ascites in the
obese patient is problematic. An abdominal ultrasound
may be required to determine with certainty if uid is
present. Ascites usually is present for only a few weeks
before the patient seeks medical attention. In contrast, a
slowly enlarging abdomen over months to years is most
likely due to obesity not ascites.
The diagnosis of new-onset ascites is suspected on the
basis of the history and physical examination and usually
conrmed by successful abdominal paracentesis and/or
ultrasound. The diagnosis of the etiology of ascites forma-
tion is based on the results of the history, physical exam-
ination, and ascitic uid analysis. In general, few other
tests are required. However, the liver is commonly imaged
to screen for hepatocellular carcinoma, portal vein throm-
bosis, and hepatic vein thrombosis.
Abdominal Paracentesis
Abdominal paracentesis with appropriate ascitic uid
analysis is probably the most rapid and cost-effective
method of diagnosing the cause of ascites.
16,17
Fluid due
to portal hypertension can be readily differentiated from
uid due to other causes.
10
Also, in view of the high prev-
alence of ascitic uid infection at the time of admission to
the hospital, an admission surveillance tap may detect
unexpected infection.
18
Although older published series reported a relatively
high morbidity, and even mortality, when trocars were
used for paracentesis, more recent studies regarding para-
Table 1. Grading System for Recommendations
Classication Description
Class I Conditions for which there is evidence and/or general
agreement that a given diagnostic evaluation, procedure
or treatment is benecial, useful, and effective.
Class II Conditions for which there is conicting evidence and/or a
divergence of opinion about the usefulness/efcacy of a
diagnostic evaluation, procedure or treatment.
Class IIa Weight of evidence/opinion is in favor of
usefulness/efcacy.
Class IIb Usefulness/efcacy is less well established by evidence/
opinion.
Class III Conditions for which there is evidence and/or general
agreement that a diagnostic
evaluation/procedure/treatment is not useful/effective
and in some cases may be harmful.
Level of
Evidence Description
Level A Data derived from multiple randomized clinical trials or meta-
analyses.
Level B Data derived from a single randomized trial, or nonrandomized
studies.
Level C Only consensus opinion of experts, case studies, or standard-
of-care.
Table 2. Differential Diagnosis of Ascites
Cirrhosis
Alcoholic hepatitis
Heart failure
Cancer (peritoneal carcinomatosis, massive liver metastases, etc)
Mixed ascites, i. e., cirrhosis plus another cause for ascites
Pancreatitis
Nephrotic syndrome
Tuberculous peritonitis
Acute liver failure
Budd-Chiari syndrome
Sinusoidal obstruction syndrome
Postoperative lymphatic leak
Myxedema
2088 RUNYON HEPATOLOGY, June 2009
centesis complications in patients with ascites docu-
mented no deaths or infections caused by the
paracentesis.
19
Complications were reported in only
about 1% of patients (abdominal wall hematomas), de-
spite the fact that 71% of the patients had an abnormal
prothrombin time.
19
Although more serious complica-
tions (hemoperitoneum or bowel entry by the paracente-
sis needle) occur,
20
they are sufciently unusual
(1/1000 paracenteses) that they should not deter per-
formance of this procedure. In a study of 4729 paracen-
teses, investigators reported that eight of nine bleeding
complications occurred in patients with renal failure; per-
haps the qualitative platelet abnormality in this setting
predisposes to more bleeding.
21
Although some physicians give blood products (fresh
frozen plasma and/or platelets) routinely before paracen-
tesis in patients with cirrhosis and coagulopathy, this pol-
icy is not data-supported.
19,22
Routine tests of coagulation
also do not reect bleeding risk in patients with cirrhosis;
these patients regularly have normal global coagulation
because of a balanced deciency of procoagulants and
anticoagulants.
23
In a recent survey of the use of blood
products in relation to paracentesis, 50% of approxi-
mately 100 hepatologists attending a conference on co-
agulopathy in liver disease indicated that they either never
used plasma before procedure or used it only if the inter-
national normalized ratio was 2.5.
24
The risks and costs
of prophylactic transfusions may exceed the benet. Co-
agulopathy should preclude paracentesis only when there
is clinically evident hyperbrinolysis (three-dimensional
ecchymosis/hematoma) or clinically evident disseminated
intravascular coagulation. A shortened (120 minutes)
euglobulin clot lysis time documents hyperbrinolysis.
25
However, this test may not be routinely available. Epsilon
aminocaproic acid can be used to treat hyperbrinolysis;
paracentesis can be performed after the lysis time has nor-
malized on treatment.
26
Bleeding conditions occur in less
than 1/1000 patients who require paracentesis. There is
no data-supported cutoff of coagulation parameters be-
yond which paracentesis should be avoided.
19
In a study
of 1100 large-volume paracenteses, there were no hemor-
rhagic complications despite (1) no prophylactic transfu-
sions, (2) platelet counts as low as 19,000 cells/mm
3
(19 10
6
/L) (54%50,000), and (3) international nor-
malized ratios for prothrombin time as high as 8.7 (75%
1.5 and 26.5%2.0).
22
In the past, the avascular midline, midway between the
pubis and the umbilicus, was usually chosen as the site for
paracentesis. Now, because many paracenteses are per-
formed to remove a large volume of uid and abdominal
obesity increases the midline wall thickness, the left lower
quadrant is the preferred location (Fig. 1). The abdominal
wall in the left lower quadrant, 2 nger breadths (3 cm)
cephalad and 2 nger breadths medial to the anterior
superior iliac spine, has been shown to be thinner and
with a larger pool of uid than the midline and is usually
a good choice for needle insertion for performance of a
therapeutic paracentesis.
27
The right lower quadrant may
be a suboptimal choice in the setting of a dilated cecum
(due to lactulose) or an appendectomy scar. The area of
the inferior epigastric arteries should be avoided; these
vessels are located midway between the pubis and anterior
superior iliac spines and then run cephalad in the rectus
sheath. Visible collaterals should also be avoided. A lapa-
roscopic study found that collaterals can be present in the
midline and thus present a risk for rupture during para-
centesis.
28
If the uid is difcult to localize by examination be-
cause of obesity, ultrasonography can be a useful adjunct
in locating uid and visualizing the spleen and other
structures to be avoided. There are few contraindications
to paracentesis. The procedure should be performed by a
provider who has been trained in its performance.
Recommendations:
1. Abdominal paracentesis should be performed
and ascitic uid should be obtained from inpatients
and outpatients with clinically apparent new-onset
ascites. (Class I, Level C)
2. Because bleeding is sufciently uncommon, the
routine prophylactic use of fresh frozen plasma or
platelets before paracentesis is not recommended.
(Class III, Level C)
Fig. 1. Diagram of the abdomen showing the three usual sites for
abdominal paracentesis. The author prefers the left lower quadrant site.
Reproduced from Thomsen TW, Shaffer RW, White B, Setnik GS. Para-
centesis. N Engl J Med 2006;355:e21, with permission from the Mas-
sachusetts Medical Society. Copyright (2006) Massachusetts Medical
Society. All rights reserved.
HEPATOLOGY, Vol. 49, No. 6, 2009 RUNYON 2089
Ascitic Fluid Analysis
An algorithm approach seems preferable to ordering a
large number of tests on most specimens (Table 3). If
uncomplicated ascites due to cirrhosis is suspected, only
screening tests (e.g., cell count and differential, albumin
and total protein concentration) are performed on the
initial specimen. If the results of these tests are unexpect-
edly abnormal, further testing can be performed on an-
other ascitic uid sample. Also, many laboratories save an
aliquot of uid for a fewdays; this uid can be tested if the
specimen has been handled properly. However, because
most specimens are consistent with uncomplicated cir-
rhotic ascites, no further testing will be needed in the
majority of patients.
If ascitic uid infection is suspected (fever, abdominal
pain, unexplained encephalopathy, acidosis, azotemia,
hypotension, or hypothermia), bacterial culture of the
uid in blood culture bottles inoculated at the bedside
should be performed. Use of a urine dipstick to detect
neutrophils in ascitic uid takes only 90 seconds to 2
minutes.
29,30
However, the largest study of a urine dip-
stick (2123 paracenteses) demonstrated a sensitivity of
only 45%.
31
Development of an ascites-specic dipstick
in contrast to a urine dipstick is needed. Automated cell
counting has been shown to be accurate in one study; the
result is rapidly available and could replace the manual
cell count if it is further validated.
32
Additional testing,
e.g., for total protein, lactate dehydrogenase (LDH), and
glucose to assist in differentiating spontaneous from sec-
ondary bacterial peritonitis, can be performed on the ini-
tial specimen based on clinical judgment.
33
An ascitic
uid carcinoembryonic antigen 5 ng/mL or ascitic uid
alkaline phosphatase 240 U/L has also been shown to be
accurate in detecting gut perforation into ascitic uid.
34
The serum-ascites albumin gradient (SAAG) has been
proved in prospective studies to categorize ascites better
than the total-proteinbased exudate/transudate concept
and better than modied pleural uid exudate/transudate
criteria.
11,35
Calculating the SAAG involves measuring
the albumin concentration of serumand ascitic uid spec-
imens obtained on the same day and subtracting the as-
citic uid value from the serum value. If the SAAG is
1.1 g/dL (11 g/L), the patient has portal hypertension,
with approximately 97% accuracy.
11
Patients who have
portal hypertension plus a second cause for ascites forma-
tion also have a SAAG 1.1 g/dL.
Patients undergoing serial outpatient therapeutic para-
centeses probably should be tested only for cell count and
differential
36,37
(the author has detected eight episodes of
spontaneous bacterial peritonitis [SBP] in approximately
400 paracenteses in a paracentesis clinic in 2 years [un-
published observations]). Bacterial culture is not neces-
sary in asymptomatic patients undergoing serial large-
volume paracenteses.
The most expensive tests are the cytology and smear
and culture for mycobacteria; these tests should probably
be ordered only when there is a high pretest probability of
occurrence of the disease under consideration. The ascitic
uid cytology is positive only in the setting of peritoneal
carcinomatosis.
38
The sensitivity of cytology in detecting
peritoneal carcinomatosis is 96.7% if three samples are
sent and processed promptly; the rst sample is positive in
82.8% and at least one of two samples is positive in
93.3%.
38
In this study, 50 mL of fresh warm ascitic uid
were hand-carried to the laboratory for immediate pro-
cessing. Use of DNA cytometry or magnetic enrichment
may improve the sensitivity of cytology further.
39,40
Pa-
tients with peritoneal carcinomatosis usually have a his-
tory of a breast, colon, gastric, or pancreatic primary
carcinoma. The sensitivity of smear for mycobacteria is
approximately 0%; the sensitivity of uid culture for my-
cobacteria is approximately 50%.
41
Only patients at high
risk for tuberculous peritonitis (e.g., recent immigration
froman endemic area or acquired immunodeciency syn-
drome)
42
should have testing for mycobacteria on the rst
ascitic uid specimen. Laparoscopy with biopsy and my-
cobacterial culture of tubercles are the most rapid and
accurate methods of diagnosing tuberculous peritonitis.
Multiple prospective trials have shown that bacterial
growth occurs in only about 50% of instances when as-
citic uid with a polymorphonuclear leukocyte (PMN)
count 250 cells/mm
3
(0.25 10
9
/L) is cultured by
older methods, i.e., sending a syringe or tube of uid to
the laboratory, as compared to approximately 80% if the
Table 3. Ascitic Fluid Laboratory Data*
Routine Optional Unusual Unhelpful
Cell count and differential Culture in blood culture bottles AFB smear and culture pH
Albumin Glucose Cytology Lactate
Total protein Lactate dehydrogenase Triglyceride Cholesterol
Amylase Bilirubin Fibronectin
Grams stain Glycosaminoglycans
Abbreviation: AFB, acid-fast bacteria. *Adapted from Runyon.
17
Reprinted with permission from W.B. Saunders.
uid is inoculated into blood culture bottles at the bedside
and prior to administration of antibiotics.
43,44
Differential Diagnosis
Although cirrhosis is the cause of ascites formation in
most patients, approximately 15%have a cause other than
liver disease, including cancer, heart failure, tuberculosis,
or nephrotic syndrome (Table 3).
10
Approximately 5%of
patients with ascites have two or more causes of ascites
formation, i.e., mixed ascites.
10
Usually, these patients
have cirrhosis plus one other cause, e.g., peritoneal carci-
nomatosis or peritoneal tuberculosis. Many patients with
enigmatic ascites are eventually found to have two or even
three causes for ascites formation (e.g., heart failure, dia-
betic nephropathy, and cirrhosis due to nonalcoholic ste-
atohepatitis). In this setting, the sum of predisposing
factors leads to sodium and water retention when each
individual factor might not be severe enough to cause
uid overload.
The cancer antigen 125 (CA125) warrants mention.
Essentially all patients, including men with ascites or
pleural uid of any cause, have an elevated serumCA125;
when ascites is controlled, the CA125 level decreases dra-
matically.
45,46
This test is elevated when mesothelial cells
are under pressure from the presence of uid; it is very
nonspecic. When this test is found to be abnormal, the
female patient may be unnecessarily referred for gyneco-
logic surgery even if the ovaries were removed decades
earlier; cirrhosis is regularly detected at laparotomy as the
cause for ascites formation (because it is most common
cause) rather than ovarian cancer, and the patient may die
postoperatively. Patients with ascites should not have se-
rum tested for CA125.
Recommendations:
3. The initial laboratory investigation of ascitic
uid should include an ascitic uid cell count and
differential, ascitic uid total protein, and SAAG.
(Class I, Level B)
4. If ascitic uid infection is suspected, ascitic uid
should be cultured at the bedside in blood culture
bottles prior to initiation of antibiotics. (Class I, Level
B)
5. Other studies of ascitic uid can be ordered
based on pretest probability of disease (Table 3).
(Class IIa, Level C)
6. Testing serum for CA125 is not helpful in the
differential diagnosis of ascites. Its use is not recom-
mended in patients with ascites of any type. (Class III,
Level B)
Treatment of Ascites
Appropriate treatment of patients with ascites depends
on the cause of uid retention. SAAG can be helpful
diagnostically as well as in decision-making regarding
treatment. Patients with low SAAG (1.1 g/dL) ascites
usually do not have portal hypertension and, with the
exception of nephrotic syndrome, do not respond to salt
restriction and diuretics.
17
In contrast, patients with a
high SAAG (1.1 g/dL) have portal hypertension and
usually are responsive to these measures.
17
The remainder of this guideline is applicable only to
patients with cirrhosis as the cause of their ascites. Im-
provement in the outcome of patients with nonportal-
hypertensionrelated ascites depends on successful
treatment of the underlying disorder.
Alcohol-induced liver injury is one of the most revers-
ible causes of liver disease that leads to high SAAG as-
cites.
17
One of the most important steps in treating ascites
in this setting is to treat the underlying liver disease by
ceasing alcohol consumption. In a period of months, ab-
stinence can result in dramatic improvement in the revers-
ible component of alcoholic liver disease. One recent
study demonstrates that patients who have Child-Pugh
class C cirrhosis due to alcohol and who stop drinking
have an approximately 75% 3-year survival, but all those
who continue to drink die in 3 years.
47
Ascites may resolve
or become more responsive to medical therapy with ab-
stinence and time. Decompensated hepatitis B cirrhosis
can also have a dramatic response to antiviral treatment.
48
Liver diseases other than those that are related to alcohol,
hepatitis B, and autoimmune hepatitis are less reversible;
by the time ascites is present, these patients may be best
served by referral for liver transplantation evaluation
rather than protracted medical therapy.
The mainstays of treatment of patients with cirrhosis
and ascites include (1) education regarding dietary so-
dium restriction (2000 mg/day [88 mmol/day]) and (2)
oral diuretics.
16,17
More stringent dietary sodium restric-
tion can speed mobilization of ascites, but is not recom-
mended because it is less palatable and may further
worsen the malnutrition that is usually present in these
patients. Fluid loss and weight change are directly related
to sodium balance in patients with portal hypertension
related ascites. It is sodium restriction, not uid restric-
tion, which results in weight loss, as uid follows sodium
passively.
49
Measurement of urinary sodiumexcretion is a
helpful parameter to followwhen rapidity of weight loss is
less than desired.
16,17
Randomurinary sodiumconcentra-
tions are of value when they are 0 mmol/L or 100
mmol/L but are much less helpful when they are interme-
diate because of lack of uniformity of sodium excretion
during the day and lack of knowledge of total urine vol-
ume, which may vary from 300 mL to greater than 3000
mL. Twenty-four-hour collections of urine for determi-
nation of sodium excretion are much more informative
than random specimens; however, full-day collections are
cumbersome. Providing patients with verbal and written
instructions, a container, and a lab order slip to turn in
with the completed specimen helps insure compliance.
Completeness of collection of the 24-hour specimen can
be assessed by measurement of urinary creatinine. Men
with cirrhosis should excrete more than 15 mg creatinine
per kilogram of body weight per day, and women with
cirrhosis should excrete more than 10 mg/kg/day. Less
creatinine is indicative of an incomplete collection. Total
nonurinary sodium excretion is less than 10 mmol/day in
afebrile patients with cirrhosis without diarrhea.
50
One of
the goals of treatment is to increase urinary excretion of
sodium so that it exceeds 78 mmol/day (88 mmol intake/
day 10 mmol nonurinary excretion per day). Only the
10%-15% of patients who have spontaneous natriuresis
78 mmol/day can be considered for dietary sodium re-
striction alone (i.e., without diuretics). However, when
given a choice, most patients would prefer to take some
diuretics and have a more liberal sodium intake than take
no pills and have a more severe sodium restriction.
A random spot urine sodium concentration that is
greater than the potassiumconcentration correlates with a
24-hour sodiumexcretion greater than 78 mmol/day with
approximately 90%accuracy.
51
This urine sodium/potas-
sium ratio may replace the cumbersome 24-hour collec-
tion.
Fluid restriction is not necessary in treating most pa-
tients with cirrhosis and ascites. The chronic hyponatre-
mia usually seen in patients with cirrhosis and ascites is
seldom morbid unless it is rapidly corrected in the oper-
ating room at the time of liver transplantation.
52
A study
of 997 patients with cirrhosis and ascites demonstrates
that the serum sodium is 120 mmol/L in only 1.2% of
patients and 125 mmol/L in only 5.7%.
53
Attempts to
rapidly correct hyponatremia in this setting with hyper-
tonic saline can lead to more complications than the hy-
ponatremia itself.
54
Preliminary data suggest that
aquaretic drugs have the promise of correcting hyponatre-
mia. The intravenous aquaretic agent conivaptan has been
studied in patients with cirrhosis and is approved for use
for treatment of euvolemic and hypervolemic hyponatre-
mia in hospitalized patients.
55
Caution is advised by the
manufacturer in the use of this drug in patients with cir-
rhosis. An oral preparation tolvaptan increases serum so-
dium in patients who have pretreatment values 130
mmol/L.
56
However, whether these agents will be effec-
tive without side effects in the subset of patients with
cirrhosis who are more in need of correction of hypona-
tremia (serum sodium 120 mmol/L) remains un-
proven. Cost-effectiveness also warrants investigation.
Unfortunately, many drugs that have theoretical promise
in treating ascites, e.g., angiotensin-converting enzyme
inhibitors, have been shown to aggravate hypotension and
have not been clinically useful. Severe hyponatremia does
warrant uid restriction in the patient with cirrhosis and
ascites; however, there is no data-supported specic
threshold for initiating uid restriction. A serum sodium
120-125 mmol/L is a reasonable threshold. Patients
with cirrhosis do not usually have symptoms from hypo-
natremia until the sodium is 110 mmol/L or unless the
decline in sodium is very rapid.
Although it is traditional to recommend bed rest
(based on extrapolation fromheart failure), this is imprac-
tical and there are no controlled trials to support this
practice. Upright posture may aggravate the plasma renin
elevation found in patients with cirrhosis with ascites.
Theoretically, this may increase sodium avidity. This the-
oretical concern would have to translate into clinically
relevant outcomes before bed rest could be advocated.
The usual diuretic regimen consists of single morning
doses of oral spironolactone and furosemide, beginning
with 100 mg of the former and 40 mg of the latter.
16,17
Previously, single-agent spironolactone was advocated,
but hyperkalemia and the long half-life of this drug have
resulted in its use as a single agent only in patients with
minimal uid overload.
57
Single-agent furosemide has
been shown in a randomized controlled trial to be less
efcacious than spironolactone.
58
The good oral bioavail-
ability of furosemide in the patient with cirrhosis, to-
gether with the acute reductions in glomerular ltration
rate associated with intravenous furosemide, favor use of
the oral route of administration.
59,60
A randomized trial
purports to demonstrate that spironolactone should be
used as a single agent, with furosemide added only for
refractory patients.
61
Diuresis was slower in the single-
agent spironolactone group with a lesser need for dose
adjustments; thus, this approach may be useful for outpa-
tients.
61
However, another randomized trial indicates that
initial combination treatment shortens the time to mobi-
lization of moderate ascites.
62
Most patients require com-
bination treatment eventually. The largest study ever
performed (involving 3860 patients with cirrhosis and
ascites) used combination therapy from the beginning.
63
Starting with both drugs appears to be the preferred ap-
proach in achieving rapid natriuresis and maintaining
normokalemia. An alternative approach would be to start
with single-agent spironolactone, in particular in the out-
patient setting.
The doses of both oral diuretics can be increased simul-
taneously every 3-5 days (maintaining the 100 mg:40 mg
ratio) if weight loss and natriuresis are inadequate. In
general, this ratio maintains normokalemia. Usual maxi-
mum doses are 400 mg/day of spironolactone and 160
mg/day of furosemide.
16,17
Furosemide can be tempo-
rarily withheld in patients presenting with hypokalemia;
this is very common in the setting of alcoholic hepatitis.
Patients with parenchymal renal disease (e.g., diabetic ne-
phropathy or immunoglobulin A nephropathy or those
having undergone liver transplantation) may tolerate less
spironolactone than usual because of hyperkalemia. Sin-
gle morning dosing maximizes compliance. Amiloride
(10-40 mg/day) can be substituted for spironolactone in
patients with tender gynecomastia. However, amiloride is
more expensive and has been shown to be less effective
than an active metabolite of spironolactone in a random-
ized controlled trial.
64
Triamterene, metolazone, and hy-
drochlorothiazide have also been used to treat ascites.
65-67
Hydrochlorothiazide can also cause rapid development of
hyponatremia when added to the combination of spi-
ronolactone and furosemide.
67
Eplenerone is a new aldo-
sterone antagonist that has been used in heart failure.
68
It
has not been studied in the setting of cirrhosis and ascites.
Newer loop diuretics must be proven to be superior to
current drugs before their expense can be justied. Al-
though an intravenous dose of 80 mg furosemide can
cause an acute reduction in renal perfusion and subse-
quent azotemia in patients with cirrhosis and ascites, this
same dose has been shown in one study to separate diuret-
ic-resistant (50 mmol urine sodium in 8 hours) from
diuretic-sensitive patients (50 mmol).
69
Another study
has conrmed this observation.
70
This intravenous furo-
semide test may help speed detection of diuretic-resis-
tant patients so that they can more rapidly be given
second-line treatment options.
69
However, intravenous
furosemide can cause azotemia (see below), and its re-
peated use should probably be minimized until its safety
and efcacy are evaluated in randomized trials.
In the largest, multicenter, randomized controlled trial
performed in patients with ascites, dietary sodiumrestric-
tion and a dual diuretic regimen with spironolactone and
furosemide has been shown to be effective in more than
90%of patients in achieving a reduction in the volume of
ascites to acceptable levels.
63
An unblinded randomized controlled trial in patients
with new-onset ascites demonstrates that weekly 25 g in-
fusions of albumin for 1 year followed by infusions every
2 weeks improved survival compared to diuretics alone.
71
However, further studies including cost-effectiveness
analysis in the United States are required before this ex-
tremely expensive treatment can be advocated.
Outpatient treatment can be attempted initially. How-
ever, some patients with cirrhosis and ascites also have
gastrointestinal hemorrhage, hepatic encephalopathy,
bacterial infection, and/or hepatocellular carcinoma, and
may require hospitalization for denitive diagnosis and
management of their liver disease as well as management
of their uid overload. Frequently, intensive education is
required to ensure patient understanding that the diet and
diuretics are actually effective and worth the effort.
There is no limit to the daily weight loss of patients
who have massive edema. Once the edema has resolved,
0.5 kg is probably a reasonable daily maximum.
72
Uncon-
trolled or recurrent encephalopathy, serumsodium120
mmol/L despite uid restriction, or serum creatinine
2.0 mg/dL (180 mol/L) should lead to cessation of
diuretics, reassessment of the situation, and consideration
of second-line options.
In the past, patients with ascites frequently occupied
hospital beds for prolonged periods of time because of
confusion regarding diagnosis and treatment and because
of iatrogenic problems. Although an abdomen without
clinically detectable uid is a reasonable ultimate goal, it
should not be a prerequisite for discharge from the hospi-
tal. Patients who are stable, with ascites as their major
problem, can be discharged to the clinic after it has been
determined that they are responding to their medical reg-
imen. However, in order for patients to be discharged
early from the hospital, they should be seen in the outpa-
tient setting promptly, ideally within approximately 1
week of discharge.
Management of Tense Ascites
An initial large-volume paracentesis rapidly relieves
tense ascites. A prospective study has demonstrated that a
single 5-L paracentesis can be performed safely without
post-paracentesis colloid infusion in the patient with di-
uretic-resistant tense ascites.
73
Larger volumes of uid
have been safely removed with the administration of in-
travenous albumin (8 g/L of uid removed).
74
However,
large-volume paracentesis does nothing to correct the un-
derlying problem that led to ascites formation, i.e., so-
dium retention. Large-volume paracentesis predictably
removes the uid more rapidly (minutes) than does care-
ful diuresis (days to weeks).
75
A single large-volume para-
centesis followed by diet and diuretic therapy is
appropriate treatment for patients with tense ascites.
73,75
In the diuretic-sensitive patient, to serially remove uid
by paracentesis when it could be removed with diuretics
seems inappropriate.
In order to prevent reaccumulation of uid, sodium
intake should be reduced and urinary sodium excretion
should be increased with diuretics. Determining the op-
timal diuretic doses for each patient, by titrating the doses
upward every 3-5 days until natriuresis and weight loss are
achieved, can take some time. The intravenous furo-
semide test may shorten this time. However, this should
be tested in the context of a randomized trial.
69
Although
a controlled trial has demonstrated that large-volume
paracentesis is predictably faster than diuretic therapy for
patients with cirrhosis and tense ascites, it should not be
viewed as rst-line therapy for all patients with ascites.
75
In the outpatient clinic, body weight, orthostatic
symptoms, and serum electrolytes, urea, and creatinine
are monitored. If weight loss is inadequate, a randomspot
urine sodium/potassium ratio or 24-hour urine sodium
can be measured. Patients who are excreting urine sodi-
um/potassium1 or 24-hour urine sodium78 mmol/
day and are not losing weight are consuming more
sodium in their diet than 88 mmol/day and should be
counseled further about dietary sodiumrestriction. These
patients should not be labeled as diuretic-resistant and
should not proceed to second-line therapy until it is doc-
umented that they are compliant with the diet.
Patients who do not lose weight and excrete 78
mmol sodium/day should receive an attempt at a higher
dose of diuretics. Frequency of follow-up is determined
by response to treatment and stability of the patient.
Some patients warrant evaluation every 2-4 weeks until it
is clear that they are responding to treatment and not
developing problems. Thereafter, evaluation every few
months may be appropriate. Intensive outpatient treat-
ment, in particular with regard to diet education, may
help prevent subsequent hospitalizations.
Development of ascites as a complication of cirrhosis is
associated with a poor prognosis.
9
Liver transplantation
should be considered in the treatment options for these
patients.
Recommendations:
7. Patients with ascites who are thought to have an
alcohol component to their liver injury should abstain
from alcohol consumption. (Class I, Level B)
8. First-line treatment of patients with cirrhosis
and ascites consists of sodium restriction (88 mmol/
day [2000 mg/day]) and diuretics (oral spironolactone
with or without oral furosemide). (Class IIa, Level A)
9. Fluid restriction is not necessary unless serum
sodium is less than 120-125 mmol/L. (Class III, Level
C)
10. An initial therapeutic abdominal paracentesis
should be performed in patients with tense ascites.
Sodium restriction and oral diuretics should then be
initiated. (Class IIa, Level C)
11. Diuretic-sensitive patients should preferably be
treated with sodium restriction and oral diuretics
rather than with serial paracenteses. (Class IIa, Level
C)
12. Liver transplantation should be considered in
patients with cirrhosis and ascites. (Class I, Level B)
Refractory Ascites
Refractory ascites is dened as uid overload that (1) is
unresponsive to sodium-restricted diet and high-dose di-
uretic treatment (400 mg/day spironolactone and 160
mg/day furosemide) or (2) recurs rapidly after therapeutic
paracentesis.
76
Prostaglandin inhibitors such as nonste-
roidal anti-inammatory drugs can reduce urinary so-
dium excretion in patients with cirrhosis and can induce
azotemia.
77
These drugs can convert patients fromdiuret-
ic-sensitive to refractory and should be avoided in this
setting. Failure of diuretic therapy may be manifested by
(1) minimal to no weight loss together with inadequate
(78 mmol/day) urinary sodium excretion despite di-
uretics or (2) development of clinically signicant com-
plications of diuretics, e.g., encephalopathy, serum
creatinine 2.0 mg/dL, serumsodium120 mmol/L, or
serum potassium 6.0 mmol/L. Randomized trials have
shown that fewer than 10% of patients with cirrhosis and
ascites are refractory to standard medical therapy.
58,63
Op-
tions for patients refractory to routine medical therapy
include (1) serial therapeutic paracenteses, (2) liver trans-
plantation, (3) transjugular intrahepatic portasystemic
stent-shunt (TIPS), (4) peritoneovenous shunt, and (5)
experimental medical therapy.
Serial therapeutic paracenteses are effective in control-
ling ascites. This has been known since the time of the
ancient Greeks. Controlled trials demonstrating the safety
of this approach have now been published.
75
Even in pa-
tients with no urine sodium excretion, paracenteses per-
formed approximately every 2 weeks control ascites.
16,17
Frequency of paracentesis provides insight into the pa-
tients degree of compliance with the diet. The sodium
concentration of ascitic uid is approximately equivalent
to that of plasma in these patients: 130 mmol/L. A 6-L
paracentesis removes 780 mmol of sodium (130 mmol/
L 6 L 780 mmol). A10-L paracentesis removes 1300
mmol. Patients consuming 88 mmol of sodium per day,
excreting approximately 10 mmol/day in nonurinary
losses, and excreting no urinary sodium retain a net of 78
mmol/day. Therefore, a 6-L paracentesis removes 10 days
(780 mmol or 78 mmol/day) of retained sodium and a
10-L paracentesis removes approximately 17 days of re-
tained sodium(1300 mmol or 78 mmol/day 16.7 days)
in patients with no urinary sodium excretion. Patients
with some urinary sodium excretion should require para-
centeses even less frequently. Patients requiring paracen-
teses of approximately 10 L more frequently than every 2
weeks are clearly not complying with the diet.
In recent years, newparacentesis equipment (e.g., mul-
tihole, large-bore needle and a pump) has become avail-
able that may improve the ease and speed of paracentesis.
Although one might predict that therapeutic paracentesis
would have a higher complication rate than diagnostic
paracentesis, this has not been borne out by prospective
studies.
19,22
One controversial issue regarding therapeutic paracen-
tesis is that of colloid replacement. In one study, 105
patients with tense ascites were randomized to receive
albumin (10 g/L of uid removed) versus no albumin,
after therapeutic paracentesis.
78
Being refractory to di-
uretic treatment was not a prerequisite for entry into this
study; in fact, 31.4% of patients had not received diuret-
ics.
78
The group that received no albumin developed sta-
tistically signicantly more (although asymptomatic)
changes in electrolytes, plasma renin, and serum creati-
nine than the albumin group, but no more clinical mor-
bidity or mortality.
78
Although another study has
documented that the subset of patients who develop a rise
in plasma renin after total paracentesis have decreased life
expectancy, there has been no study large enough to dem-
onstrate decreased survival in patients who are given no
plasma expander compared to patients given albumin af-
ter paracentesis.
79
Furthermore, the activation in vaso-
constrictor systems that can follow large-volume
paracentesis may not be related to a decreased intravascu-
lar volume.
80
Also, albumin infusions markedly increase
albumin degradation, and albumin is very expen-
sive.
74,81-83
In a study performed more than 40 years ago,
58% of infused albumin was accounted for by increased
degradation, and a 15% increase in serum albumin led to
a 39% increase in degradation.
81
Additionally, in vitro
studies have shown that increasing albumin concentra-
tion in cell culture media has been shown to decrease
albumin synthesis.
83
Asystematic reviewof 79 randomized trials of albumin
use in multiple settings, including 10 trials in patients
with ascites, did not make denitive statements about its
use except in the setting of SBP (see section below).
84
The
American Thoracic Societys consensus statement in-
cluded the 7000-patient Saline versus Albumin Fluid
Evaluation (SAFE) trial, which demonstrated no differ-
ence in 28-day mortality in the critical care setting.
85
In
view of the extremely high cost of albumin, future studies
also should include cost analyses. Nevertheless, albumin is
being used after therapeutic paracentesis. While more
studies are awaited, it is reasonable although not manda-
tory to give it for paracenteses greater than 5 L.
78
Studies have infused between 5 and 10 g of albumin
per liter of uid removed.
78-80
No study has compared
doses. If albumin is infused, providing 6-8 g/L of uid
removed seems appropriate. In Europe, only a 20%intra-
venous solution is available. In the United States, 5% and
25% intravenous solutions are available. Both are iso-
tonic. Infusion of the 5% solution increases the sodium
load ve-fold.
Nonalbumin plasma expanders such as dextran 70, hy-
droxyethylstarch, and even saline have been advocated,
also without demonstration of a survival advantage.
79,86
Hydroxyethylstarch can ll Kupffer cells and cause portal
hypertension even in patients without underlying liver
disease.
87
Terlipressin appears to be as effective as albu-
min in suppressing plasma renin elevation in a random-
ized trial; this drug is not currently available in the United
States.
88
Part of the controversy regarding post-paracentesis
plasma expanders relates to study design. More studies are
needed, in particular studies that target survival as the
specic study endpoint in patients with truly diuretic-
resistant ascites. Chronic therapeutic paracenteses should
be reserved for the 10% of patients who truly fail diuretic
treatment. Some patients may benet from albumin in-
fusion after large-volume paracentesis. What are needed
are risk factors that permit preparacentesis identication
of the subset of patients who are at higher risk of postpara-
centesis circulatory dysfunction. Serial paracenteses also
deplete proteins, may aggravate malnutrition, and predis-
pose to infection.
89
Liver transplantation should be considered in the treat-
ment options of patients with ascites. Once patients be-
come refractory to routine medical therapy, 21% die
within 6 months.
90
Referral should not be delayed in
patients with refractory ascites.
TIPS is a side-to-side portacaval shunt that is usually
placed by an interventional radiologist using local anes-
thesia.
91-96
In some centers, especially in Europe, the pro-
cedure may be performed by hepatologists. General
anesthesia is used in some centers. One randomized trial
comparing TIPS to large-volume paracentesis demon-
strated higher mortality in the TIPS group, but this study
was very small and took place very early in our experience
with this relatively new technique.
93
Four large-scale,
multicenter randomized controlled trials comparing
TIPS to sequential large-volume paracenteses have been
completed and published.
91,92,94,95
(Table 4). All of these
report better control of ascites in the TIPS group. One
reports no survival advantage by univariate analysis but a
statistically signicant survival advantage for the TIPS
group by multivariate analysis.
91
Another reports preven-
tion of hepatorenal syndrome but with higher costs in the
TIPS group: there were similar rates of encephalopathy
overall but more severe hepatic encephalopathy in the
TIPS group.
92
Another study shows no survival advantage
with TIPS, but a trend (P 0.058) toward more moder-
ate or severe encephalopathy in the TIPS group and no
effect on quality of life.
94
The most recently published
study reports a survival advantage in the TIPS group with
similar hospitalization rates but more severe encephalop-
athy with TIPS.
95
Multiple meta-analyses have been pub-
lished regarding these trials.
96-101
They all report better
control of ascites and more encephalopathy in the TIPS
group. Unfortunately recurrent tense ascites is frequently
a manifestation of noncompliance on the part of the pa-
tient rather than refractory ascites. The most recent meta-
analysis, which used individual patient data, reports
signicantly (P 0.035) improved transplant-free sur-
vival with TIPS and similar cumulative probability of
developing a rst episode of encephalopathy.
101
Only one trial required a specic cutoff of cardiac ejec-
tion fraction (50%) for eligibility for enrollment.
94
Due
to their hyperdynamic circulation, the ejection fraction of
the patient with cirrhosis is usually greater than 70%-
75%.
102
An ejection fraction of greater than 60% may be
more appropriate as an inclusion criterion for entry into a
TIPS study, because patients with an ejection fraction
between 50% and 60% and those with diastolic dysfunc-
tion may have a higher risk of post-TIPS heart failure and
reduced survival.
103,104
Patients with parenchymal renal disease, especially
those on dialysis, may not respond as well to TIPS as those
with functional renal insufciency.
105
Meanwhile, a polytetrauoroethylene-covered stent
has been developed that has more than twice the interval
of patency of the uncoated stent at 1 year in a randomized
trial; this shunt is associated with a greater 2-year survival
than that seen with uncoated stents in a retrospective
multicenter study.
106,107
Also, a scoring system, Model for
End-Stage Liver Disease (MELD), has been developed
and validated to predict 3-month mortality after TIPS.
108
All of the trials mentioned above were initiated before the
coated shunt was available and before this scoring system
was popularized. Furthermore, some investigators and
some trials have withheld diuretics after TIPS. This fur-
ther limits its efcacy. TIPS usually converts diuretic-
resistant patients into diuretic-sensitive patients. Giving
diuretics after TIPS and titrating the doses to achieve
natriuresis is appropriate.
As the experience with TIPS continues, the level of
sophistication of patient screening improves (e.g., ejec-
tion fraction and MELD), and the technology of the stent
itself improves, the results of future trials may be better
than past trials. More randomized trials are planned.
Meanwhile, TIPS should be second-line therapy. There is
a more detailed discussion of TIPS in the practice guide-
line on this topic.
109
Peritoneovenous shunt, e.g., LeVeen or Denver, was
popularized in the 1970s as a physiologic treatment of
ascites. Shunt placement has been shown in controlled
trials to decrease the duration of hospitalization, decrease
the number of hospitalizations, and decrease the dose of
diuretics.
63,110
However, poor long-term patency, exces-
sive complications, and no survival advantage compared
to medical therapy in controlled trials have led to near
abandonment of this procedure.
70,110
A randomized con-
trolled trial of uncoated TIPS versus peritoneovenous
shunt reports better long-term efcacy in the TIPS
group.
111
There are no trials of coated TIPS versus peri-
toneovenous shunt. Shunt-related brous adhesions and
even cocoon formation after peritoneous shunt can
make subsequent liver transplantation difcult. Peritone-
ovenous shunting should probably now be reserved for
diuretic-resistant patients who are not candidates for
transplant or TIPS, and who are not candidates for serial
therapeutic paracenteses because of multiple abdominal
Table 4. Large-Scale Randomized Controlled Trials of TIPS Versus Serial Large-Volume Paracenteses
Ref.
Number Inclusion Criteria
Method of Randomization
and Analysis N Control of Ascites Survival Encephalopathy
91 Tense ascites and
failure of 4
weeks of therapy
No details 60 61% vs. 18% (P 0.006) 69% vs. 52% (P 0.11) 58% vs. 48%*
92 Ascites refractory to
medical therapy
Sealed opaque envelope; 70 51% vs. 17% (P 0.003) 41% vs. 35%* All 77% vs. 66% (P 0.29)
Intention to treat Severe 60% vs. 34% (P
0.03)
94 Refractory ascites No details; Intention to
treat
109 58% vs. 16% (P 0.001) 40% vs. 37%* Moderate-severe 38% vs. 12%
(P 0.058)
95 Refractory or
recidivant
No details 66 79% vs. 42% (P 0.0012) 77% vs. 52% (P 0.021) Severe (P 0.039)
*P value not signicant.
surgical scars or distance from a physician willing to per-
form and capable of performing paracenteses. Peritone-
ovenous shunting could also be considered before
transplant in patients who are not candidates for TIPS,
with the realization that surgery in the right upper quad-
rant can make subsequent transplant more difcult. Re-
cent experience in shunt insertion by the surgeon may also
be a factor in optimizing results in the rare patient who is
selected to undergo this procedure.
Interventional radiologists have reported the possibil-
ity of performing a peritoneovenous shunt without the
participation of a surgeon.
112
Radiologists are also placing
plastic subcutaneous access ports for paracentesis.
113
Ra-
diologists and surgeons have collaborated to develop a
device that drains ascitic uid into the urinary bladder.
114
None of these new techniques has been studied in ran-
domized trials. We await the results of such studies before
placing these innovations into our algorithm.
There are several experimental treatment options for
patients with refractory ascites. In addition to the un-
blinded randomized controlled trial (mentioned above) of
regular albumin infusion in patients with new-onset as-
cites, there is a retrospective study demonstrating efcacy
of weekly albumin infusions of 50 g in reducing body
weight in patients with refractory ascites who were not
candidates for TIPS.
71,115
Regular infusions of albumin
for treatment of new-onset or refractory ascites should be
considered experimental until more studies demonstrate
efcacy and cost-effectiveness. A pilot randomized trial of
0.075 mg of oral clonidine twice per day versus placebo in
patients with cirrhosis, ascites, and a plasma norepineph-
rine level of 300 pg/mL demonstrated more rapid mo-
bilization of ascites with fewer complications.
116
Another
pilot randomized trial of paracentesis plus albumin versus
clonidine plus spironolactone in patients with cirrhosis,
refractory ascites, and a plasma norepinephrine level of
300 pg/mL demonstrated fewer hospitalizations in the
latter group.
117
A pilot study of subcutaneous octreotide
in two patients with refractory ascites demonstrated an
improvement in renal function and hemodynamics and a
reduction in renin and aldosterone.
118
Clearly, more data
are needed before these experimental options can be
placed in the treatment algorithm.
Recommendations
13. Serial therapeutic paracenteses are a treatment
option for patients with refractory ascites. (Class I,
Level C)
14. Postparacentesis albumin infusion may not be
necessary for a single paracentesis of less than 4-5 L.
(Class I, Level C)
15. For large-volume paracenteses, an albumin in-
fusion of 6-8 g/L of uid removed can be considered.
(Class IIa, Level C)
16. Referral for liver transplantation should be
expedited in patients with refractory ascites. (Class
IIa, Level C)
17. TIPS may be considered in appropriately se-
lected patients who meet criteria similar to those of
published randomized trials. (Class I, Level A)
18. Peritoneovenous shunt, performed by a surgeon
experienced with this technique, should be considered
for patients with refractory ascites who are not can-
didates for paracenteses, transplant, or TIPS. (Class
IIb, Level A)
Hepatorenal Syndrome
Diagnosis
The major criteria for the diagnosis of hepatorenal syn-
drome in the setting of cirrhosis were updated in 2007
and include (1) cirrhosis with ascites; (2) serumcreatinine
1.5 mg/dL; (3) no improvement of serum creatinine
(decrease to a level of 1.5 mg/dL or less) after at least 2
days with diuretic withdrawal and volume expansion with
albumin
119
(The recommended dose of albumin is 1 g/kg
body weight/day up to a maximum of 100 g/day); (4)
absence of shock; (5) no current or recent treatment with
nephrotoxic drugs; and (6) absence of parenchymal kid-
ney disease as indicated by proteinuria 500 mg/day,
microhematuria (50 red blood cells per high power
eld), and/or abnormal renal ultrasonography.
119
Many
of the older studies did not involve measurement of car-
diac lling pressures to exclude the possibility of intravas-
cular volume depletion. A more recent study used
albumin to achieve a central venous pressure of 3 cm of
water.
120
Two types of hepatorenal syndrome have been
described. Type I is characterized by rapidly progressive
reduction in renal function as dened by a doubling of the
initial serum creatinine to a level 2.5 mg/dL or a 50%
reduction of the initial 24-hour creatinine clearance to a
level 20 mL/minute in less than 2 weeks. Type II does
not have a rapidly progressive course and is a common
cause of death in patients who do not die of other com-
plications of cirrhosis.
119
Treatment
Hemodialysis is frequently used to control azotemia
and maintain electrolyte balance before liver transplanta-
tion. Many patients require it for a variable interval after
transplant. Hypotension during dialysis is a common
problem. However, without transplantation, survival is
dismal; one older series reported no survivors out of 25
patients.
121
A more recent study reports that eight of 30
patients with hepatorenal syndrome survived 30 days
with use of hemodialysis or continuous venovenous he-
modialysis in the intensive care unit setting.
122
Continu-
ous venovenous hemoltration/hemodialysis causes less
hypotension but requires the continuous involvement of a
dialysis nurse.
123
In a study that screened 3860 patients
with cirrhosis and ascites and included an armfor patients
with hepatorenal syndrome, peritoneovenous shunting
was not shown to improve survival in hepatorenal syn-
drome; however, there were only 33 patients with hepa-
torenal syndrome, and a type II error could not be
excluded.
63
Furthermore, this study was performed before
the types of hepatorenal syndrome were delineated.
Many pharmaceutical treatments, predominantly va-
soconstrictors, including some that are not available in the
United States, have been studied. Usually, short case se-
ries with or without historical controls are reported. Re-
cently, treatments have been much more successful for
type I hepatorenal syndrome. Dopamine is the traditional
drug that has been used clinically. The drug combination,
along with albumin infusion, that has been reported from
Europe and the United States is octreotide and mido-
drine.
124,125
In the initial study, ve patients received
10-20 g intravenous albumin per day for 20 days, plus
octreotide with a target dose of 200 g subcutaneously
three times per day, and midodrine titrated up to a max-
imum of 12.5 mg orally three times per day to achieve an
increase in mean blood pressure of 15 mm Hg.
124
Results
were superior to those of eight patients treated with do-
pamine and albumin.
124
This regimen can be adminis-
tered outside of an intensive care unit and can even be
given at home.
124
A retrospective study from the United
States involving 60 patients treated with octreotide/mido-
drine/albumin and 21 concurrent nonrandomized albu-
min-treated controls reported reduced mortality in the
treatment group (43% versus 71%, P 0.05).
125
An
uncontrolled pilot study of this drug combination fol-
lowed by TIPS reported improved renal function and
natriuresis.
126
Two studies, including one with random-
ization and crossover design, demonstrate that octreotide
alone is not benecial for hepatorenal syndrome; mido-
drine appears to be required in addition.
127,128
Another
pilot study, this one using norepinephrine plus albumin,
reports 83%(10 of 12 patients) success in reversing type I
hepatorenal syndrome; this treatment requires that the
patient be in an intensive care unit.
129
An uncontrolled
trial using terlipressin (not available in the United States)
also reports success with type I hepatorenal syndrome.
130
A U.S. multicenter, randomized, controlled trial of terli-
pressin versus placebo in 112 patients with type I hepato-
renal syndrome nearly achieved signicance (P 0.059)
in its primary endpoint (survival at 14 days with serum
creatinine 1.5 mg/dL on two occasions); unfortunately,
there was no survival advantage.
131
A European multi-
center, randomized, controlled trial of terlipressin and
albumin versus albumin alone in 46 patients with type I
or type II hepatorenal syndrome demonstrated an im-
provement in renal function but no survival advantage at
3 months.
132
A meta-analysis of studies of terlipressin
demonstrated a 52% efcacy in reversing hepatorenal
syndrome.
133
Whether terlipressin will become available
in the United States remains to be seen. TIPS alone has
also been reported to be effective in treatment of type I
hepatorenal syndrome in an uncontrolled study of seven
patients.
134
Two studies have now been published involving pa-
tients with type II hepatorenal syndrome. One uncon-
trolled study involved terlipressin treatment of 11 patients
followed by TIPS in nine; renal function improved sig-
nicantly compared to pretreatment levels.
135
Another
pilot uncontrolled study of TIPS in 18 patients awaiting
liver transplantation reported total remission of ascites
in eight patients and partial response. . .without the need
of paracentesis in 10 patients.
136
Enthusiasm is high for these new treatments.
137
What
are needed are more well-designed, randomized con-
trolled trials before we know where to place these options
in the treatment algorithm. Until further data are avail-
able, albumin, octreotide, and midodrine should be con-
sidered in the treatment of type I hepatorenal syndrome.
It has been known for 30 years that liver transplan-
tation is an effective treatment for hepatorenal syndrome;
this will probably never be studied in a randomized tri-
al.
138
Recommendations:
19. Albumin infusion plus administration of vaso-
active drugs such as octreotide and midodrine should
be considered in the treatment of type I hepatorenal
syndrome. (Class IIa, Level B)
20. Patients with cirrhosis, ascites, and type I he-
patorenal syndrome should have an expedited referral
for liver transplantation. (Class I, Level B)
Spontaneous Bacterial Peritonitis
Diagnosis
Ascitic uid infection is sufciently common (12% in
a recent series) at the time of admission of a patient with
cirrhosis and ascites to justify a diagnostic paracentesis.
18
The diagnosis of SBP is made when there is a positive
ascitic uid bacterial culture and an elevated ascitic uid
absolute PMN count (i.e., 250 cells/mm
3
[0.25 10
9
/
L]) without an evident intra-abdominal, surgically treat-
able source of infection.
139
An abdominal paracentesis
must be performed and ascitic uid must be analyzed
before a condent diagnosis of ascitic uid infection can
be made. A clinical diagnosis of infected ascitic uid
without a paracentesis is not adequate. Empiric treatment
of suspected infection without a sample for testing does
not permit narrowing the spectrumof coverage compared
to the situation when an organism is cultured that is sus-
ceptible to a narrow-spectrum antibiotic. Even a single
dose of an effective broad-spectrum drug causes the cul-
ture to produce no growth in 86% of cases; only resistant
ora are detected.
33
Dipstick testing of ascitic uid and
automated cell counts may improve early detection of this
infection.
29-32
Empiric Treatment
Patients with ascitic uid PMN counts 250 cells/
mm
3
(0.25 10
9
/L) in a clinical setting compatible with
ascitic uid infection should receive empiric antibiotic
therapy (Table 5).
17,139
An elevated ascitic uid PMN
count probably represents evidence of failure of the rst
line of defense, the peritoneal macrophages, to kill invad-
ing bacteria. Most of the bacterial cultures of these uid
samples will grow bacteria if (1) the uid is cultured in
blood culture bottles, (2) there has been no prior antibi-
otic treatment, and (3) there is no other explanation for an
elevated PMNcount, e.g., hemorrhagic ascites, peritoneal
carcinomatosis, pancreatitis, or peritoneal tuberculo-
sis.
17,43,140
The patients who meet the above criteria but
have negative cultures have been labeled with a diagnosis
of culture-negative neutrocytic ascites.
140
The initial
threshold PMN count for making this diagnosis was 500
cells/mm
3
(0.5 10
9
/L).
140
However, subsequent studies
have revised this threshold to 250 cells/mm
3
(0.25
10
9
/L).
141
Patients with culture-negative neutrocytic as-
cites have similar signs, symptoms, and mortality as pa-
tients with SBP and warrant empiric antibiotic
treatment.
140
A prospective study in which two paracen-
teses were performed in rapid sequence (approximately 8
hours apart) before initiation of antibiotic therapy has
demonstrated that only 8% of patients with culture-pos-
itive ascitic uid with an elevated PMN count become
culture-negative spontaneously.
142
The majority of pa-
tients with culture-positive neutrocytic ascites demon-
strate rising bacterial counts and rising PMNcounts when
serial samples are obtained in rapid sequence before initi-
ation of antibiotic therapy.
142
The majority of patients
with culture-negative neutrocytic ascites continue with
this pattern of ascitic uid analysis when serial samples are
obtained in rapid sequence before initiation of antibiotic
therapy; 34.5% become culture-positive.
143
The ascitic uid PMN count is more rapidly available
than the culture and appears to be accurate in determin-
ing who really needs empiric antibiotic treatment.
17,139
Delaying treatment until the ascitic uid culture grows
bacteria may result in the death of the patient from over-
whelming infection. In some patients, infection is de-
tected at the bacterascites stage before there is a neutrophil
response, i.e., 250 cells/mm
3
(0.25 10
9
/L); this has
been labeled monomicrobial nonneutrocytic bacteras-
cites.
143
Most patients62% in one studyresolve the
colonization without antibiotics and without a neutrophil
response.
143
Patients with bacterascites who do not re-
solve the colonization and who progress to SBP have signs
or symptoms of infection at the time of the paracentesis
that documents bacterascites.
142,143
Therefore, patients
with cirrhosis and ascites who have convincing signs or
symptoms of infection (fever, abdominal pain, or unex-
Table 5. Treatment of Spontaneous Bacterial Peritonitis (SBP)
Ref
No. Study Design
Method of
Randomization and
Analysis N Results P Mortality P
145 Cefotaxime vs. ampicillin/ Random number table 73 Cure of infection 0.02 Infection-related mortality 19% vs 31% NS
Tobramycin for severe
infections
85% vs 56% Hospitalization mort 33% vs 43% NS
148 Cefotaxime 5 days vs. 10 days Sealed opaque envelope 100 Cure 93% vs.
91%
NS Infection-related mortality 0% vs 4% NS
For SBP Intention to treat Recurrence 12%
vs 13%
Hospitalization NS
Mortality 33% vs. 43% NS
150 Oral ooxacin vs Sealed envelope 123 Resolution NS Hospitalization NS
Cefotaxime for SBP 84 vs 85% mortality 19% vs 19% NS
152 Cefotaxime with or without
albumin for SBP
Sealed envelope 126 Resolution 98%
vs 94%
NS Hospitalization mortality 10% vs 29% .01
Renal failure
0.002
10% vs 33%
Abbreviations: AFTP, ascitic uid total protein; NS, not signicant; HRS, hepatorenal syndrome.
plained encephalopathy) should receive empiric treat-
ment until the culture results are known regardless of the
PMN count in ascitic uid.
The patient with alcoholic hepatitis represents a special
case. These patients may have fever, leukocytosis, and
abdominal pain that can masquerade as SBP. In addition,
they can develop SBP. These patients do not develop
false-positive elevated ascitic uid PMN counts because
of peripheral leukocytosis
144
; an elevated PMN count
must be presumed to represent SBP. Empiric antibiotic
treatment (for presumed ascitic uid infection) of patients
with alcoholic hepatitis who have fever and/or peripheral
leukocytosis can be discontinued after 48 hours if ascitic
uid, blood, and urine cultures demonstrate no bacterial
growth.
Relatively broad-spectrum therapy is warranted in pa-
tients with suspected ascitic uid infection until the re-
sults of susceptibility testing are available. Cefotaxime, a
third-generation cephalosporin, has been shown to be su-
perior to ampicillin plus tobramycin in a controlled
trial.
145
Cefotaxime or a similar third-generation cepha-
losporin appears to be the treatment of choice for sus-
pected SBP; it covers 95% of the ora including the three
most common isolates: Escherichia coli, Klebsiella pneu-
moniae, and pneumococci
145
(Table 5). Widespread use
of quinolones to prevent SBP in high-risk subgroups of
patients (see below) has led to a change in ora with more
gram-positives and quinolone-resistant bacteria in recent
years.
146
Dosing of cefotaxime 2 g intravenously every 8
hours has been shown to result in excellent ascitic uid
levels (20-fold killing power after one dose).
147
After sen-
sitivities are known, the spectrum of coverage can usually
be narrowed. Arandomized controlled trial involving 100
patients has demonstrated that 5 days of treatment is as
efcacious as 10 days in the treatment of carefully charac-
terized patients with SBP.
148
An uncontrolled study dem-
onstrated that 5 days of ceftriaxone 1 g intravenously
twice per day was effective in treating culture-negative
neutrocytic ascites.
149
Ceftriaxone is highly protein
bound; this is a potential limitation in its ability to pene-
trate low protein ascitic uid.
Oral Treatment. Oral ooxacin (400 mg twice per
day for an average of 8 days) has been reported in a ran-
domized controlled trial to be as effective as parenteral
cefotaxime in the treatment of SBP in patients without
vomiting, shock, grade II (or higher) hepatic encephalop-
athy, or serum creatinine 3 mg/dL.
150
Only 61% of
patients with SBP met study inclusion criteria. All treat-
ment was given in hospitalized patients.
150
Intravenous
ciprooxacin followed by oral administration of this drug
was found to be more cost-effective compared to intrave-
nous ceftazidime in a randomized trial in patients who
had not received quinolone prophylaxis.
151
Patients who
have received quinolone prophylaxis may become in-
fected with ora resistant to quinolones and should be
treated with alternative agents.
Intravenous Albumin Infusion in Addition to Ce-
fotaxime. One controlled trial randomized patients with
SBP to receive cefotaxime alone versus cefotaxime plus
1.5 g albumin per kilogrambody weight within 6 hours of
enrollment and 1.0 g/kg on day 3.
152
A decrease in mor-
tality from 29% to 10% was reported.
152
Improving con-
trol of a complication of advanced cirrhosis is commonly
reported; however, dramatically improving survival is sel-
domshown. A more recent study has shown that albumin
should be given when the serum creatinine is 1 mg/dL,
blood urea nitrogen 30 mg/dL, or total bilirubin 4
mg/dL, but is not necessary in patients who do not meet
these criteria.
153
Albumin has been shown to be superior
to hydroxyethylstarch in treatment of SBP.
154
Distinction from Secondary Bacterial Peritonitis
Secondary bacterial peritonitis, i.e., ascitic uid infec-
tion caused by a surgically treatable intra-abdominal
source, can masquerade as SBP. Secondary peritonitis can
be divided into two subsets: those with free perforation of
a viscus (e.g., duodenal ulcer) and those with loculated
abscesses in the absence of perforation (e.g., perinephric
abscess). Signs and symptoms do not help separate pa-
tients who need surgical intervention (both subsets of
secondary peritonitis) fromthose who have SBP and need
only antibiotic treatment.
33
In contrast, the initial ascitic
uid analysis and the response to treatment can assist with
this important distinction.
33
The characteristic analysis in
the setting of free perforation is PMN count 250 cells/
mm
3
(usually many thousands), multiple organisms (fre-
quently including fungi and enterococcus) on Gramstain
and culture, and at least two of the following criteria: total
protein 1 g/dL, lactate dehydrogenase greater than the
upper limit of normal for serum, and glucose 50 mg/
dL.
33
It is useful to order an ascitic uid Gram stain,
culture, total protein, LDH, and glucose in patients with
cirrhosis and ascites and an ascitic uid PMN count
250 cells/mm
3
. These criteria have been shown to have
100% sensitivity but only 45% specicity in detecting
perforation in a prospective study.
33
An ascitic uid car-
cinoembryonic antigen 5 ng/mL or ascitic uid alkaline
phosphatase 240 U/L has also been shown to be accu-
rate in detecting gut perforation into ascitic uid with a
sensitivity of 92% and specicity of 88%; these criteria
would not be predicted to be useful in nonperforation
secondary peritonitis.
34
Patients who fulll either set of
criteria for gut perforation should undergo emergent
plain and upright lms, water-soluble contrast studies of
the gut, and/or computed tomographic scanning.
33,34
The total protein, LDH, and glucose criteria are only
50% sensitive in detecting nonperforation secondary
peritonitis; the follow-up PMN count after 48 hours of
treatment assists in detecting these patients.
33
The 48-
hour PMN count is essentially always below the pretreat-
ment value in SBP when an appropriate antibiotic is used;
in contrast, the PMN count rises despite treatment in
nonperforation secondary peritonitis.
21
Patients documented to have free perforation or non-
perforation secondary peritonitis should receive anaerobic
coverage in addition to a third-generation cephalosporin
and should undergo laparotomy.
33
The mortality of sec-
ondary peritonitis treated with antibiotics and surgery is
similar to that of SBP treated with antibiotics.
33
Follow-Up Paracentesis
A follow-up ascitic uid analysis is not needed in many
patients with infected ascites.
155
The majority of patients
have SBP in the typical setting (i.e., advanced cirrhosis)
with typical symptoms, typical ascitic uid analysis (total
protein 1 g/dL, LDH less than the upper limit of nor-
mal for serum, and glucose 50 mg/dL), a single organ-
ism, and a dramatic clinical response.
17,155
Repeat
paracentesis can be performed to document sterility of
culture and dramatic decrease in PMN count in patients
with SBP; however, it is not necessary. In contrast, if the
setting, symptoms, analysis, organism(s), or response are
atypical, repeat paracentesis can be helpful in raising the
suspicion of secondary peritonitis and prompting further
evaluation and surgical intervention when appropriate.
33
Recommendations:
21. Patients with ascites admitted to the hospital
should undergo abdominal paracentesis. Paracentesis
should be repeated in patients (whether in the hospital
or not) who develop signs or symptoms or laboratory
abnormalities suggestive of infection (e.g., abdominal
pain or tenderness, fever, encephalopathy, renal fail-
ure, acidosis, or peripheral leukocytosis). (Class I,
Level B)
22. Patients with ascitic uid PMN counts >250
cells/mm
3
(0.25 10
9
/L) should receive empiric an-
tibiotic therapy, e.g., an intravenous third-generation
cephalosporin, preferably cefotaxime 2 g every 8
hours. (Class I, Level A)
23. Oral ooxacin (400 mg twice per day) can be
considered a substitute for intravenous cefotaxime in
inpatients without prior exposure to quinolones, vom-
iting, shock, grade II (or higher) hepatic encephalop-
athy, or serum creatinine >3 mg/dL. (Class IIa, Level
B)
24. Patients with ascitic uid PMN counts <250
cells/mm
3
(0.25 10
9
/L) and signs or symptoms of
infection (temperature >100F or abdominal pain or
tenderness) should also receive empiric antibiotic ther-
apy, e.g., intravenous cefotaxime 2 g every 8 hours,
while awaiting results of cultures. (Class I, Level B)
25. When the ascitic uid of a patient with cirrho-
sis is found to have a PMN count >250 cells/mm
3
(0.25 10
9
/L) and there is high suspicion of second-
ary peritonitis, it should also be tested for total pro-
tein, LDH, glucose, Gram stain, carcinoembryonic
antigen, and alkaline phosphatase to assist with the
distinction of SBP from secondary peritonitis. (Class
IIa, Level B)
26. Patients with ascitic uid PMN counts >250
cells/mm
3
(0.25 10
9
/L) and clinical suspicion of
SBP, who also have a serum creatinine >1 mg/dL,
blood urea nitrogen >30 mg/dL, or total bilirubin >4
mg/dL should receive 1.5 g albumin/kg body weight
within 6 hours of detection and 1.0 g/kg on day 3.
(Class IIa, Level B)
Prevention of SBP
The identication of risk factors for development of
SBP (including ascitic uid protein concentration 1.0
g/dL, variceal hemorrhage, and prior episode of SBP) has
led to randomized controlled trials of prophylactic anti-
biotics
156-162
(Table 6). Noroxacin 400 mg/day orally
has been reported to successfully prevent SBP in (1) pa-
tients with low-protein ascites and (2) patients with prior
SBP.
157-158
Noroxacin 400 mg orally twice per day for 7
days helps prevent infection in patients with variceal hem-
orrhage.
159
An antibiotic can be given intravenously while
the patient is actively bleeding; ooxacin (400 mg/day)
has been validated for this purpose.
160
Ceftriaxone given
intravenously 1 g/day for 7 days has been shown to be
superior to oral noroxacin in a randomized trial.
161
Ad-
ministering ve doses of double-strength trimethoprim/
sulfamethoxazole or a single oral dose of 750 mg
ciprooxacin per week has also been reported to be effec-
tive in preventing SBP in patients with cirrhosis and as-
cites.
162,163
However, intermittent dosing may select
resistant ora more rapidly.
164
Daily dosing of this drug
combination may be better than intermittent dosing. Se-
lective intestinal decontamination with noroxacin or tri-
methoprim/sulfamethoxazole has not been shown to
prolong survival in humans in individual trials. However,
these studies were not designed to detect a survival advan-
tage. Ameta-analysis of ve trials in patients with cirrhosis
and gastrointestinal bleeding has shown a survival advan-
tage of 9.1% in the treated group.
165
A group in France reported a reduction in hospitaliza-
tion mortality for patients with variceal hemorrhage from
43% 20 years ago to 15% recently; much of the reduced
mortality was attributed to use of antibiotics to prevent
infections.
166
Selective intestinal decontamination does select resis-
tant gut ora, which can subsequently cause spontaneous
infection; fortunately, infection-causing bacteria that are
resistant to quinolones are usually sensitive to cefo-
taxime.
167
A report from a center in which selective intes-
tinal decontamination has been routine in high-risk
patients for many years documents a change in the ora of
bacterial infections with a predominance of gram-positive
organisms, compared to a predominance of gram-nega-
tive organisms in the past.
146
This is cause for concern and
emphasizes the importance of limiting selective intestinal
decontamination to patients at high risk. Selective intes-
tinal decontamination with noroxacin or trimethoprim/
sulfamethoxazole in patients with prior SBP or low-
protein ascitic uid does appear to be cost-effective.
168,169
One trial in which patients with low-protein (1
g/dL) ascitic uid or bilirubin 2.5 mg/dL were random-
ized either to continuous noroxacin or to inpatient-only
noroxacin demonstrated that continuous noroxacin re-
duced SBP compared to inpatient-only prophylaxis.
170
However, patients receiving continuous noroxacin had a
higher risk of resistant ora when they did develop infec-
tion.
170
A more recent randomized trial of daily noroxa-
cin versus placebo in patients with ascitic uid protein
1.5 g/dL and at least one of the following: serum creat-
inine 1.2 mg/dL, blood urea nitrogen 25 mg/dL, se-
rumsodium130 mEq/L or Child-Pugh 9 points with
bilirubin 3 mg/dL demonstrated prevention of SBP as
well as hepatorenal syndrome and a survival advantage in
the noroxacin group.
171
Based on the available literature,
it is reasonable to give noroxacin (or trimethoprim/sul-
famethoxazole) continuously to patients who meet these
criteria.
162,170,171
In a report of liver transplant infections, one risk factor
for posttransplant fungal infection was prolonged ther-
apy with ciprooxacin.
172
There are no published ran-
domized trials of selective intestinal decontamination
versus placebo in preventing infections in patients await-
ing liver transplantation. Use of long-term selective intes-
tinal decontamination in this setting in the absence of
prior SBP is not data-supported.
Parenteral antibiotics to prevent sclerotherapy-related
infections do not appear to be warranted, based on a con-
trolled trial.
173
It is the active bleeding that appears to be
the risk factor for infection, not sclerotherapy.
174
Variceal
banding has largely replaced sclerotherapy; antibiotics
would be even less likely to be of benet in the setting of
banding.
Recommendations:
27. Intravenous ceftriaxone for 7 days or twice-
daily noroxacin for 7 days should be given to prevent
bacterial infections in patients with cirrhosis and gas-
trointestinal hemorrhage. (Class I, Level A)
Table 6. Prevention of Spontaneous Bacterial Peritonitis (SBP)
Ref
No. Study Design
Method of
Randomization and
Analysis N Results P Mortality P
157 Noroxacin vs. no drug No details 63 SBP 0% vs. 23% 0.05 Infection-related mortality (0% vs. 13%) NS
In inpatients with AFTP Hospitalization mortality (6% vs. 16%) NS
158 Noroxacin vs. placebo in
patients with prior SBP
No details 80 SBP recurrence
12% vs. 35%
0.014 18% vs. 25% NS
159 Noroxacin vs. no drug in
patients with cirrhosis and
gut hemorrhage
No details 119 Infection 10% vs.
37%
0.001 7% vs. 12% NS
161 Noroxacin vs ceftriaxone Computer-generated 111 Infection 0.003 9% vs 11% NS
In patients with cirrhosis and
gut hemorrhage
envelopes 33% vs 11%
162 Trimethoprim/sulfamethoxazole
vs. no drug in patients with
cirrhosis and ascites
No details 67 SBP or bacteremia
(3% vs. 27%)
0.025 7% vs. 20% .15
165 Meta-analysis of antibiotic
prevention of infection in
patients with cirrhosis and
gut hemorrhage
Meta-analysis 534 32% reduction in
infection
0.001 9% increase in survival .004
171 Noroxacin vs placebo in
patients who met criteria
Computer-generated
envelopes
68 SBP 7% vs 61% 0.001 3-mo 94% vs 62% 0.003
HRS 28% vs 7% 0.02 12-mo 60% vs 48% 0.05
Abbreviations: AFTP, ascitic uid total protein; NS, not signicant; HRS, hepatorenal syndrome.
28. Patients who have survived an episode of SBP
should receive long-term prophylaxis with daily nor-
oxacin (or trimethoprim/sulfamethoxazole) because
this is the most data-supported indication for long-
term outpatient prophylaxis. (Class I, Level A)
29. In patients with cirrhosis and ascites but no
gastrointestinal bleeding, long-term use of noroxacin
(or trimethoprim/sulfamethasoxazole) can be justied
if the ascitic uid protein <1.5 g/dL and at least one
of the following is present: serum creatinine >1.2
mg/dL, blood urea nitrogen >25 mg/dL, serum so-
dium <130 mEq/L or Child-Pugh >9 points with
bilirubin >3 mg/dL. (Class I, Level B)
30. Intermittent dosing of antibiotics to prevent
bacterial infections may be inferior to daily dosing
(due to the development of bacterial resistance) and
thus daily dosing should preferentially be used. (Class
IIb, Level C)
Acknowledgment: This guideline was commissioned
and approved by the AASLD and represents the position
of the Association. This guideline was produced in collab-
oration with the AASLDPractice Guidelines Committee.
Members of the AASLD Practice Guidelines Committee
included Margaret C. Shuhart, M.D., M.S., Chair; Gary
L. Davis, M.D. (Board Liaison); Kiran Bambha, M.D.;
Andres Cardenas, M.D., M.M.Sc.; Timothy J. Davern,
M.D.; Christopher P. Day, M.D., Ph.D.; Steven-Huy B.
Han, M.D.; Charles D. Howell, M.D.; Lawrence U. Liu,
M.D.; Paul Martin, M.D.; Nancy Reau, M.D.; Bruce A.
Runyon, M.D.; Jayant A. Talwalkar, M.D., M.P.H.;
John B. Wong, M.D.; and Colina Yim, RN, MN.
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