Anaphylaxis

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CHAPTER 2

Life-threatening emergencies

Treatment algorithm for adults with


anaphylaxis1
Anaphylactic reaction?
Airway, Breathing, Circulation, Disability, Exposure
Diagnosis - look for:
Acute onset of illness
Life-threatening airway and/or breathing
and/or circulation problems1
And usually skin changes
Call for help
Lie patient flat
Raise patients legs
Adrenaline2

When skills and equipment available:


Establish airway
High flow oxygen
Monitor:
IV fluid challenge3
Pulse oximetry
Chlorphenamine4
ECG
Hydrocortisone5
Blood pressure

1 Life-threatening problems:
Airway:
Swelling, hoarseness, stridor
Breathing:
Rapid breathing, wheeze, fatigue, cyanosis, SpO2 < 92%, confusion
Circulation: Pale, clammy, low blood pressure, faintness, drowsy/coma
2 Adrenaline (give IM unless experienced with IV adrenaline)
IM doses of 1:1000 adrenaline (repeat after 5 min if no better)
Adult:
500 micrograms IM (0.5 mL)
Child more than 12 years: 500 micrograms IM (0.5 mL)
Child 612 years:
300 micrograms IM (0.3 mL)
Child less than 6 years: 150 micrograms IM (0.15 mL)
Adrenaline IV to be given only by experienced specialists
Titrate: Adults 50 micrograms; Children 1 microgram/kg

Adult or child more than 12 years


Child 612 years
Child 6 months to 6 years
Child less than 6 months
See also:

3 IV fluid challenge:
Adult - 5001000 mL
Child - crystalloid 20 mL/kg
Stop IV colloid
if this might be the cause
of anaphylaxis

4 Chlorphenamine
(IM or slow IV)
10 mg
5 mg
2.5 mg
250 micrograms/kg

Anaphylactic reactions Initial treatment

Fig. 2.1 Anaphylaxis algorithm.


1 Resuscitation Council (UK) guidelines, 2008. See: www.resus.org.uk

5 Hydrocortisone
(IM or slow IV)
200 mg
100 mg
50 mg
25 mg

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