ADHDMedsandDrugAbuse 2008 06 AsktheExpert Volkow

ask the expert
AD/HD Medication and Drug Abuse

Bryan Goodman, MA, with Nora D. Volkow, MD
The results of two recent studies indicated that treating children as early as age six or seven
with stimulants for attention-deficit/hyperactivity disorder is not likely to increase the risk of substance abuse when they are adults. The studies, both sponsored by the National Institute of Drug
Abuse (NIDA) at the National Institutes of Health (NIH), also showed treatment with stimulants did
not prevent substance abuse later in adulthood. The studies, conducted by researchers at New York
University School of Medicine and the Massachusetts General Hospital/Harvard Medical School
were published in the April 2008 issue of the American Journal of Psychiatry. Bryan Goodman, MA,
executive editor of Attention magazine, talked with Nora Volkow, MD, director of NIDA, about what
the results of the studies mean to parents and their children with AD/HD.
Nora D. Volkow, MD
What do you see as the newspaper

headline for this story?
Methylphenidate treatment for children with
AD/HD does not increase their risk for later substance abuse. However, the data also show that treatment does not decrease the risk of substance abuse.
This highlights the importance of addressing not
only the treatment of AD/HD, but also of implementing prevention or treatment interventions for
substance abuse concomitantly.
And the take-away for parents
who have children with AD/HD?
As long as their children are properly diagnosed,
there does not seem to be any increased risk of their
developing substance abuse problems as a result of
exposure to stimulant medications during childhood or very early adolescence. That said, more
research is needed, especially when medication is
started in adolescence (not the focus of these studies) to ensure that this is also the case for this age
group. And, because some children with AD/HD
do develop problems with substance abuse, it is important to be watchful for early signs, to intervene
early if problems start to emerge, and to treat both
conditions simultaneously.
The study found that while medication does
not seem to increase the risk of drug abuse in
adulthood, neither does it decrease the risk of
drug abuse at that stage of life. But one would
10
Attention
think that treatment with stimulant medication

would play some role in preventing people
from becoming substance abusers.
Was there any indication from the study
why this wasnt the case? Would you care to
offer a hypothesis on why it wasnt?
My hypothesis as to why these studies did not see
a benefit in preventing substance abuse in adulthood reflects the fact that treatment of AD/HD with
stimulant medications alone may not be sufficient
to prevent the risk of drug abuse in many of these
children who, because of the disease, are at greater
risk for substance abuse.
Why did NIDA think this particular issue
was a priority?
One of the most controversial issues in childhood psychiatry today stems from the fear that
widespread use of stimulant medications to treat
children with AD/HD could increase the risk of
substance abuse in adulthood. Part of the rationale
for this is that stimulant medications, such as methylphenidate and amphetamine, share with drugs of
abuse the ability to increase dopamine concentrations in the nucleus accumbens, which is the neural
mechanism considered crucial for their reinforcing
effects. Indeed, methylphenidate and amphetamine
are sometimes abused and as a result can produce
dependence. Another rationale is related to timing
of exposure: Human epidemiological studies have
shown that the earlier an individuals exposure to
patricia marroquin / shutterstock, bonotom studio
substances with abuse potential, such as alcohol and nicotine, the greater the risk of drug abuse and dependence in
adulthood. However, an opposite perspective has also been
proposed, according to which stimulant treatment of children and adolescents with AD/HD may reduce the risk of
later substance abuse. Considering that individuals with
AD/HD are at higher-than-normal risk for substance abuse,
it is urgent for us to discriminate between the two alternatives
in order to properly address this issue.
The complex nature of the research needed in this area has
resulted in ambiguous, sometimes even contradictory, conclusions. Different investigators have found positive, negative, and even non-significant correlations between stimulant
treatment of AD/HD and the subsequent risk of substance use
disorders. These studies help to clarify some of these issues.
Were there any limitations with this research
that parents should know about? Are there plans
to replicate this study?
Yesthere are almost always limitations to any study. For
these, the most notable is that the samples are clinically referred; therefore, medication status is not randomized. The
gold standard for addressing this type of question would be
a randomized study in which some children receive medication and others do not (but receive a placebo), with a longitudinal design to measure various outcomes over time. However, this type of study would be not just extremely costly,
but also ethically untenable unless an equally effective alternative treatment for AD/HD could be offered to the comparison group. Thus, these current studies add to a growing
body of knowledge on the long-term outcomes associated
with stimulant treatment of AD/HD, but many questions

remain. Of particular importance is whether adolescents
being treated for AD/HD with stimulant medications are
protected or at greater risk of subsequent substance abuse.
Preliminary research in rats suggest that outcomes may be
different based on the age of exposure to these medications.
Given the continued high rate of stimulant medication use
The new data provide important clinical evidence

and support the current consensus about the
appropriateness of the long-established clinical
practices for the use of stimulant medication to
treat children with AD/HD.
in this country and the important nature of the remaining
questions, particularly on long-term trajectories of treated
children, I would hope that researchers will continue to step
forward to investigate these issues.
I have to ask, given your role, what you see as
some other priorities for research involving AD/HD?
Among the most important questions I see are the long-term
outcomes of treatment with AD/HD medicationson brain
development, the trajectory of the disorder, and co-occurring
problems such as substance abuse. Moreover, it is important
that we continue to evaluate behavioral therapies in addition to pharmacotherapies, and to identify the genetic, environmental, and developmental factors that influence the
June 2008
11
prevalence and course of the disorder, and the therapeutic efficacy of its treatments.
A second priority that I feel very strongly about stems
from the rapid growth of diagnosed cases (which has
stabilized in recent years in children and adolescents,
but continues to increase in adults) that has led to a dramatic surge in the availability of stimulant medications
in the market with the concomitant risk of diversion
and abuse. In my opinion, the keys to addressing this
critical issue are (a) tightening and ensuring medical
standards of diagnosis and (b) continuing to educate
the public about the dangers of nonmedical use of
stimulant medications.
Who makes the decision that one research project
is more important than another?
In addition to the peer review process, designed to evaluate the scientific merit and significance of a proposed
research project, there is a constant dialogue between
NIDAs leadership, the research community, NIDAs
12
Attention
Advisory Council (comprising scientists and members

of the public), and relevant constituency organizations.
The research agenda emerges naturally from an iterative process that consists of (a) assessing the knowledge
gaps, patients needs, and current public health challenges; (b) supporting and carrying out the basic and
clinical research needed to address them; and finally (c)
developing and testing the tools produced so that they
can be deployed and further evaluated in the health care
system.
Is there anything that we havent asked you
that you think would help parents affected by
the disorder?
I would take this opportunity to reiterate and highlight
that the new data provide important clinical evidence
and support the current consensus about the appropriateness of the long-established clinical practices for
the use of stimulant medication to treat children with
A
AD/HD.
CHADD does not endorse products, services, publications, medications or treatments, including those advertised in this magazine.

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ask the expert

AD/HD Medication and Drug Abuse

What do you see as the newspaper

think that treatment with stimulant medication

patricia marroquin / shutterstock, bonotom studio

with stimulant treatment of AD/HD, but many questions

The new data provide important clinical evidence

Advisory Council (comprising scientists and members

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