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Topical Spironolactone

This document provides a recipe and instructions for creating a 2% topical spironolactone solution. It involves crushing 12 100mg spironolactone tablets and dissolving them in 60ml of a carrier solution. It then discusses filtering out the binders from the tablets before adding the solution to a carrier of 60% ethanol, 10% propylene glycol, 20% purified water, and 10% aloe vera. Concerns are raised about using propylene glycol on sensitive skin, and alternatives like isopropyl myristate are suggested. It is also clarified that this would be a solution, not a gel, which would require additional thickening agents.

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aymen
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974 views2 pages

Topical Spironolactone

This document provides a recipe and instructions for creating a 2% topical spironolactone solution. It involves crushing 12 100mg spironolactone tablets and dissolving them in 60ml of a carrier solution. It then discusses filtering out the binders from the tablets before adding the solution to a carrier of 60% ethanol, 10% propylene glycol, 20% purified water, and 10% aloe vera. Concerns are raised about using propylene glycol on sensitive skin, and alternatives like isopropyl myristate are suggested. It is also clarified that this would be a solution, not a gel, which would require additional thickening agents.

Uploaded by

aymen
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOC, PDF, TXT or read online on Scribd
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Topical spironolactone

The recipe for 2% Topical Spiro:


12 100mg Spironlactone tablets
60ml of carrier solution (ethyl alcohol, emu oil, jojoba oil, OR etc)
http://www.anagen.net/spiroin.htm
Hmm internally that recipe would be a 6 12 day supply or a 1 3 month supply
topically.

Personally I would use my favorite Toner or natural solution (like the Vinegar-asprin
or Emu-Manuka oil) and add in the spiro. Then apply all over occasionally and spot
treat becaue Im guessing it will be pretty powerful formula
Spironolactone smells bad once in solution, so youd better use that stuff only at
night,As for the pills with all the binders the solution will have a poor efficiency, so I
would filter first the binders, the binders may also clog your pores.
Spironolactone dissolve in ethanol (ethyl alcohol) at 25 mg per ml, but dont forget
the binders so I would first buy 100 ml of ethanol throw the pills in it (not crushed)
then shake from time to time to completely dissolve.
Then you take a funnel (or a glass that can go to the oven) and put a coffee filter on
it, Ill pour the solution and wait till all the liquid is filtered, the binders (they dont
dissolve in alcohol) will stay in the filter while the spironolactone will be in the
ethanol solution. Then Ill take the funnel (or glass) and put it for 90 minutes in the
oven (ELECTRIC one) at 71C, the ethanol will evaporate and you will be left with
pure dry spironolactone powder (1,2 g), at 71C spiro doesnt degrade. . Then
youll need:

60 % of ethanol
10 % of propylene glycol (as a carrier)
20 % of purified (distilled) water
10 % of aloe vera

To be honest I wouldnt use this formula on my face and its the first time I heard of
spiro used topically to treat acne, but Im gonna use it to prevent hairloss while on
steroids (I already made the solution but without the aloe vera)

Mari added:

why would you need the ethanol (when preparing the gel) and okay i understand
the propylene glycol but what I could use instead of PG because my skin is sensitive
to propylene glycol!

mod added:

Ethanol is an alcohol and spiro like all fats needs an alcohol solution to stay in
suspension. Plus ethanol is a penetration enhancer that will act synergistically with
the propylene glycol. Ethanol will also evaporate fast once on the skin and you
wont get a residue on it.

As for the propylene glycol you can change it by any other PE (penetration
enhancer) such as isopropyl myristate (15-30%) or oleic acid or glycerol. But
propylene glycol is the best one to use after DMSO (not to be used on the face). I
have a doc that treats on transdermals and topicals and penetration enhancers, do
you want me to send it to you??

PS : its a solution not a gel, to have a gel youll need top add thickening agent such
as carbomers and adjust the ph for it to stay a gel.

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