Phar Chem 1 OBTL

UNIVERSITY OF SANTO TOMAS
Faculty of Pharmacy
An Outcomes-based Teaching Learning Program for Phar. Chem 1
2nd semester, A.Y. 2014-2015
Course Title:
Course Number:
Pharmacy and Chemistry of Inorganic Medicinals

Phar. Chem 1
Credit Units:
Contact Hours:
5 units; 3 units lecture and 2 units laboratory

Three (3) hours lecture/week and 6 hours laboratory/week
Course Placement:
First year level, 2nd semester
Pre-requisite:
Course Facilitator:
Chemistry 100
Assoc. Prof. Ma. Elena J. Manansala, M.S.Phar..
Assoc. Prof. Cristina Doria, MS Phar

Asst.Prof. Mary Catherine Chua, M.Ed, M.S. Phar. Analysis
Asst. Prof. Marife Narcida, M.S. Phar. Analysis
Course Description:
Covers theories and principles in equilibrium pertinent to medicinal and pharmaceutical applications.
Summarizes the physical and Chemical properties of each element and group in the periodic table.
Provides the chemistry and pharmacy of inorganic medicinal official in the USP and NF with special
attention on their common names, properties, preparation, and the rationale of their therapeutic uses.
Approved by:
Assoc. Prof. Ma. Elena J. Manansala

Dean
Jan. 5, 2015
Date of Approval:
Intended Learning
Outcomes
Establish the relationship
between the principles of
chemical kinetics and
chemical equilibrium
(CILO1.1)
Formulate equilibrium
expressions as applied to
homogenous and
heterogenous systems.
(CILO 3)
Content
Unit I: Chemical Principles
Applicable
to
Pharmaceutical and
Medicinal Chemistry
1. Chemical Kinetics
Reaction rates and rate law
Collision Theory of reaction
rate
Le Chateliers Principle
Factors affecting reaction
rates
2. Chemical Equilibrium
2.2 Homogenous Equilibrium
Equlibrium Constant - Ke
Equilibrium Constant for
weak acids (Ka)
Equlbrium Constant for
weak base (Kb)
Equilbrium Constant for
Water (Kw)
pH and buffers
2.3 Heterogenous Equilbrium
Equlibrium constant for
Slightly soluble compounds
(Ksp)
Teaching-Learning
Activities
Assessment
Tasks
Lecture Demonstration
Tutorial
Objective test
Scientific Laboratory
Session (no.1)
Problem sets
Problem Solving Learning

Cooperative Group
Assignment
Lecture Demonstration
Tutorial
Objective test
Laboratory experiment
(no.2)
Problem sets
Problem Solving Learning

Cooperative Group
Assignment
Laboratory
reports
Compare and
Contrast chart
Laboratory
report
Distinguish and classify

elements on the basis of
atomic structure and come
up with their chemical
properties (CILO 1.2)
Using multimedia facilities,
search the economic and
medicinal uses of
elements(CILO 4)
Unit II: Chemistry of Elements in

the Periodic Table
1. Group Properties of Elements
Group I-A Alkali Metals
Group I-B Coinage

Metals
Group II-A Alkaline

Earth Metals
Group II-B Zn, Cd, Hg
Group III-A Boron Family
Group III-B Scandium

Family
Group IV-A Carbon

Family
Group IV-B Titanium

Family
Group V-A Nitrogen

Family
Group V-B Vanadium

Family
Group VI-A Oxygen

Family
Group VI-B Chromium

Family
Group VII-A Halogens
Group VII-B Manganese

Family
Group VIII Iron Triad

Platinum
Subgroup
Group VIII-A Inert Gases
Lecturedemonstration
Objective
test
Tutorial
Memory
matrix
Compare
and Contrast
Chart
Practical
exam
Laboratory
reports
Small Group Projects

utilizing on-line sources
of updated phar. and
medicinal uses of
elements/alloys
Session (nos. 3-10)
Discuss the importance

pharmaceutical aids and
necessities in the
preparation of
pharmaceutical products.
( CILO 1.3)
Relate the electrolytes to

metabolic functions and
human well being and their
interventions (CILO 5)
Discuss different official

inorganic compounds on the
basis of their therapeutic
uses and mechanisms of
action (CILO 1.3)
Recognize the different
preparations available in
the drugstore containing
inorganic compounds. (CILO
2)
Unit III: Classification of

Inorganic Compounds
According to their Uses
1. Pharmaceutical Aids and
Necessities
Acids and Bases
Buffers
Antioxidants
Waters
Pharmaceutically Acceptable
Glass
2. Major Intra- and Extra-cellular
Electrolytes
Major Physiological Ions
Electrolytes used in Acidbase Therapy
Physiological Acid-Base
Balance
Electrolytes used in AcidBase Therapy
Electrolytes Combination
therapy
3. Essential, Non-Essential and
Trace Ions
Essential Ions
Non-Essential ions
Trace Ions
4. Gastrointestinal Agents
Acidifying
Antacids
Protectives and Adsorbents
Saline Cathartics
5. Topical Agents
Lecture
Objective test
Course Preparation
Assignment
Memory matrix
Note taking
Small group project and
assignment
Audio-visual presentations
of currents medicinal uses of
inorganic preparations and
their mechanism of actions.
session(nos. 11-17)
Compare and
contrast chart
Laboratory reports
and
pharmaceutical
preparation
Protective Agents
Antibacterials and
Astringents
6. Dental Products
Anticaries Agents
Dentrifices
7. Miscellaneous Pharmaceutical
Agents
Inhalants
Respiratory Stimulus
Expectorants and Emetics
Antidotes
Tableting Aids
Suspending Agents
8. Radiopharmaceuticals and
Contrast Media
Radiopharmaceuticals
Radiopaque and Contrast
Media
Course Textbook:
Zumdahl, S.S and Zumdahl S.A, Chemistry: An Atomic First Approach. Australia:
Thomson Brooks/Cole, 2012.
Manansala, M.E., Lecture Notes in Phar. Chem 1.
Manansala,M.E., Doria, M.C., Laboratory Manual in Phar. Chem 1
Course References:
and Pharmaceutical
Block, John H.; Roche, Edward; Soine, Taito; Wilson, Charles, Inorganic Medicinal
Chemistry. Philadelphia: Lea and Febiger, 1974

Chang, Raymond. General Chemistry The Essential Concepts, 5th edition. McGraw
Hill 2008.
Remingtons Pharmaceutical Sciences
USP 36, NF 31
Grading System:
Lecture
Quizzes
Assignments/Proje
cts
Long Exams
Total
Ratio
Laboratory
Quizzes
Long Exams
Reports/Performan
ce
Practical/Preparati
ons
Monthly
Prelims
Finals
40%
40%
40%
10%
10%
10%
50%
100%
30%
50%
100%
30%
50%
100%
30%
Monthly
40%
40%
Prelims
40%
40%
Finals
40%
40%
10%
10%
10%
10%
10%
10%
100%
100%
100%
Comprehensive
Exam
Monthly Scope
20%
Prelim Scope
40%
Final Scope 40%
100%
10%

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UNIVERSITY OF SANTO TOMAS

Pharmacy and Chemistry of Inorganic Medicinals

5 units; 3 units lecture and 2 units laboratory

First year level, 2nd semester

Assoc. Prof. Cristina Doria, MS Phar

Assoc. Prof. Ma. Elena J. Manansala

Problem Solving Learning

Problem Solving Learning

Distinguish and classify

Unit II: Chemistry of Elements in

Group I-A Alkali Metals

Group I-B Coinage

Group II-A Alkaline

Group II-B Zn, Cd, Hg

Group III-A Boron Family

Group III-B Scandium

Group IV-A Carbon

Group IV-B Titanium

Group V-A Nitrogen

Group V-B Vanadium

Group VI-A Oxygen

Group VI-B Chromium

Group VII-A Halogens

Group VII-B Manganese

Group VIII Iron Triad

Small Group Projects

Discuss the importance

Relate the electrolytes to

Discuss different official

Unit III: Classification of

Chemistry. Philadelphia: Lea and Febiger, 1974

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