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    Patient A (Click On The Link To "Complete Patient A's Karyotype")

    Uploaded by

    ZzaiRra
    This document summarizes information from completing a virtual karyotyping activity. It provides details on three patients: Patient A had Down Syndrome with an extra chromosome 21; Patient B had Klinefelter Syndrome with an extra X chromosome; Patient C died shortly after birth with Trisomy 13 Syndrome and an extra chromosome 13. The document also reviews key features for reading chromosomes and describes several genetic disorders associated with specific chromosome abnormalities.

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    Patient A (Click On The Link To "Complete Patient A's Karyotype")

    Uploaded by

    ZzaiRra
    319 views2 pages
    This document summarizes information from completing a virtual karyotyping activity. It provides details on three patients: Patient A had Down Syndrome with an extra chromosome 21; Patient B had Klinefelter Syndrome with an extra X chromosome; Patient C died shortly after birth with Trisomy 13 Syndrome and an extra chromosome 13. The document also reviews key features for reading chromosomes and describes several genetic disorders associated with specific chromosome abnormalities.

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    karyotyping.docx

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    This document summarizes information from completing a virtual karyotyping activity. It provides details on three patients: Patient A had Down Syndrome with an extra chromosome 21; Patient B had Klinefelter Syndrome with an extra X chromosome; Patient C died shortly after birth with Trisomy 13 Syndrome and an extra chromosome 13. The document also reviews key features for reading chromosomes and describes several genetic disorders associated with specific chromosome abnormalities.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    319 views2 pages

    Patient A (Click On The Link To "Complete Patient A's Karyotype")

    Uploaded by

    ZzaiRra
    This document summarizes information from completing a virtual karyotyping activity. It provides details on three patients: Patient A had Down Syndrome with an extra chromosome 21; Patient B had Klinefelter Syndrome with an extra X chromosome; Patient C died shortly after birth with Trisomy 13 Syndrome and an extra chromosome 13. The document also reviews key features for reading chromosomes and describes several genetic disorders associated with specific chromosome abnormalities.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    You are on page 1of 2

    Click on Karyotyping under human biology and read the Introduction page:

    1. What causes a dark band on the chromosome? __ Giemsa dye _


    2. What is a centromere? __________ areas where the two chromatids are joined _____

    Patient Histories: *Click on Patient Histories. You will be completing a karyotype for Patient A,
    B&C

    Patient A ( Click on the link to "Complete Patient A's Karyotype" )

    *Match the chromosome to its homolog. After all the matches are complete you'll analyze your
    patient. (Scroll down to view your completed karyotype).

    3. What is patient A's history (summarize) _______nearly full term fetus of a 40 year old
    female______________
    4. How many total chromosomes are in your karyotype - count them _47__
    The last set of chromosomes is the sex chromosomes, if you have two large chromosomes, your
    patient is XX (female), one large and one small indicates and XY (male) . What sex
    chromosomes does your patient have _XX___
    Which chromosome set has an extra + __21____
    5. What diagnosis would you give this patient (what disease)? ___Down Syndrome______

    Patient B - click on the link to go to Patient B and repeat the above process.

    6. What is Patient B's history (summarize) _______28 year old male,


    infertile____________________________
    7. How many total chromosomes are in your karyotype - count them ___47____
    What sex chromosomes does your patient have _XXY____
    Which chromosome set has an extra + __X____
    8. Finish the notation for this patient's karyotype : 47 X _XY___
    9. What is the diagnosis? ______Klinefelter's Syndrome_______________

    Patient C - click on the link to go to Patient C and repeat the above process.

    10. What is patient C's history (summarize)? _____died shortly after


    birth_________________________
    11. How many total chromosomes are in your karyotype - count them ___47_____
    What sex chromosomes does your patient have __XY____
    Which chromosome set has an extra + _13____
    12. Write out the correct notation for this karyotype. ___47 XY +13____
    13. What is the diagnosis? ____Trisomy 13 Syndrome_______________

    Go to "heredity and traits" --> "How Do Scientists Read Chromosomes"


    (Find the answers to the following questions in this area. Browse all sections)

    1. What are the three key features used to read chromosomes?


    ____size___________
    ____banding pattern_______________
    ____centromere position_____________

    2. Sketch or describe: metacentric, submetacentric, acrocentric

    metacentric - centromere is near the center


    submetacentric - one arm is much shorter than the other
    acrocentric - centromere lies at one end

    3. Got to Make a Karyotype - Try it yourself - Create your own karyotype - turning on hints is
    okay.
    Check this box when your karyotype is complete
    What did you find difficult about matching the chromosomes? __answers vary, chromsomes can
    be difficult to match________

    4. Go to - Using Karyotypes to Predict Genetic Disorders


    What is trisomy? ______extra chromosome, individual has 3 instead of 2 for a
    group______________
    What is monosomy? ____missing chromosome, only one in a pair is
    present____________________
    What is a terminal deletion? ___a chromosome is missing a piece, usually the
    tip________________

    5. For each of the Disorders, describe the chromosome abnormality and the symptoms.

    Cri Du Chat - name of this syndrome is French for "cry of the cat," caused by a delection of
    chromosome #5

    Turner Syndrome - missing or incomplete X chromosome, girls with this disorder are shorter
    than normal, and may fail to start puberty when they should.

    Klinefelter Syndrome - males who have Klinefelter syndrome have an extra X chromosome
    (XXY), males have less muscular body, and grow very little facial or body hair, also infertile

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