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    BIOFARrr

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    Filzah Falvika Putri
    This document contains pharmacokinetic data from an absorption and elimination study. It presents the concentration of a drug in plasma (Cp) over time, along with the natural log of the concentrations and pharmacokinetic parameters calculated from the data such as the elimination rate constant (Ke), half-life, and area under the curve. A linear regression analysis of the log concentration versus time data was performed to determine Ke.

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    BIOFARrr

    Uploaded by

    Filzah Falvika Putri
    14 views3 pages
    This document contains pharmacokinetic data from an absorption and elimination study. It presents the concentration of a drug in plasma (Cp) over time, along with the natural log of the concentrations and pharmacokinetic parameters calculated from the data such as the elimination rate constant (Ke), half-life, and area under the curve. A linear regression analysis of the log concentration versus time data was performed to determine Ke.

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    BIOFARrr.xlsx

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    This document contains pharmacokinetic data from an absorption and elimination study. It presents the concentration of a drug in plasma (Cp) over time, along with the natural log of the concentrations and pharmacokinetic parameters calculated from the data such as the elimination rate constant (Ke), half-life, and area under the curve. A linear regression analysis of the log concentration versus time data was performed to determine Ke.

    Copyright:

    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
    Download as xlsx, pdf, or txt
    14 views3 pages

    BIOFARrr

    Uploaded by

    Filzah Falvika Putri
    This document contains pharmacokinetic data from an absorption and elimination study. It presents the concentration of a drug in plasma (Cp) over time, along with the natural log of the concentrations and pharmacokinetic parameters calculated from the data such as the elimination rate constant (Ke), half-life, and area under the curve. A linear regression analysis of the log concentration versus time data was performed to determine Ke.

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    © All Rights Reserved
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    You are on page 1of 3

    T (hr) Cp (mg/mL) Ln Cp Ke r t1/2

    1 4.82 1.572774 0.20359 -0.99949 3.4039


    2 4.26 1.449269
    3 3.420 1.229641
    4 2.680 0.985817
    6 1.840 0.609766
    10 0.810 -0.21072
    12 0.53 -0.63488

    1.5 f(x) = - 0.203593554x + 1.8197459646


    R = 0.9989925213

    0.5

    0
    0 2 4 6 8 10 12 14

    -0.5

    -1
    i.
    waktu Cp ln Cp slope Kel AUC]tn-1-tn [AUC]0-tn k[AUC]0-tn Cp + k[AUC]0-tn
    0 0
    0.25 0.76 -0.27444 0.09500 0.095 0.0137142 0.7737142
    0.5 1.025 0.024693 0.223125 0.318125 0.04592453 1.070924525
    0.75 1.123 0.116004 0.26850 0.586625 0.08468519 1.207685185
    1 1.118 0.111541 0.28013 0.86675 0.12512403 1.24312403
    1.5 1.066 0.063913 0.54600 1.41275 0.20394459 1.26994459
    3 0.847 -0.16605 1.43475 2.8475 0.4110651 1.2580651
    6 0.552 -0.59421 -0.14436 0.14436 2.09850 4.946 0.71400456 1.26600456
    12 0.232 -1.46102 2.35200 7.298 1.05353928 1.28553928
    18 0.098 -2.32279 0.99000 8.288 1.19645568 1.29445568
    24 0.041 -3.19418 0.41700 8.705 1.2566538 1.2976538

    0.5

    0
    0 5 10 15 20 25 30
    f(x) = - 0.1441878057x + 0.2691162048
    -0.5 R = 0.9999951205

    -1 f(x) = - 3.5839741489x + 0.0021652343 T vs Ln Cp


    R = 0.9989509719 Ke
    -1.5 Linear (Ke)
    Ka
    -2 Linear (Ka)

    -2.5

    -3

    -3.5
    [AUC]t'-~ [AUC]0-~ k[AUC]0-~ FAbsorpsi FTA ln FTA slope ka

    0.6788584095 8.966858 1.29445568 0.597714 0.402286064 -0.9105918425 -3.58397 3.583974


    0.6788584095 8.966858 1.29445568 0.827316 0.172683514 -1.7562947611
    0.6788584095 8.966858 1.29445568 0.932968 0.067032419 -2.7025789169
    0.6788584095 8.966858 1.29445568 0.960345 0.039655008 -3.2275380404
    0.6788584095 8.966858 1.29445568 0.981065 0.018935442 -3.9667198933
    0.6788584095 8.966858 1.29445568 0.971887 0.02811265 -3.5715356115
    0.6788584095 8.966858 1.29445568 0.978021 0.021979215 -3.8176580343
    0.6788584095 8.966858 1.29445568 0.993112 0.006888146 -4.9779532838
    0.6788584095 8.966858 1.29445568 1 0 Err:502
    0.6788584095 8.966858 1.29445568 1.002471 -0.002471 Err:502

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