UNIT I: INTRO TO PHARMACOLOGY Common Poisons & their Antidote 3.

DIAGNOSTIC AGENTS
Agents used to determine presence or
PHARMACOLOGY absence of a condition or disease.
1. Branch of medical science Edrophonium (Tensilon) - Myasthenia
2. Science that deals with MOA, uses, A/E, gravis
and fate of drugs in animals and humans Histamine - allergies
3. Study of nature, actions & uses of drugs Technetium 99m Myocardial
4. Study of how drugs modify biochemical, perfusion scan
physiological and psychological processes
in health and disease 4. CHEMOTHERAPEUTIC AGENTS
5. Involves the study and description of the Agents used to kill or inhibit growth of
actions of drugs and chemicals on cells, cells or nucleic acid considered as foreign
tissues and the whole body to the body.
WHATARE DRUGS?
6. Includes researching on how drugs 1. Articles recognized in the official USP, official Anti-infectives
produce beneficial and adverse effects, and Homeopathic Pharmacopeia of the US or the Antineoplastics
improving the way drugs are tested to give official NF, or any supplements to any of them
greater benefit in the treatment of disease 2. Articles for use in the diagnosis, cure, THERAPEUTIC EFFECTS
mitigation, treatment, or prevention of disease in Category 0 disease prevention
PHARMACOLOGY VS. PHARMACY man or other animals. (vaccine)
PHARMACY - Involves manufacture, 3. Articles, other than food intended to affect the Category I disease etiology
structure or any function of the body of man or
preparation and dispensing of drugs (anti-pathogens)
other animals.
PHARMACOLOGY - Broad discipline 4. Articles intended for use as component of any Category II specific disease processes
encompassing all aspects of study of drugs, articles specified in clause 1, 2, or 3; but does not (antihistamines, anticancer drugs)
including their discovery, devt and actions include devices or their components parts or Category III specific disease
accessories. manifestations
BRANCHES OF PHARMACOLOGY (anti-diarrhea)
PHARMACODYNAMICS SOURCES & NATURE OF DRUGS Category IV non-specific disease
Study of what the drug does to the body Natural sources manifestations
PHARMACOKINETICS Animal sources (fever, vomiting, HA)
Study of what the body does to the drug Microbiological sources Category V non-therapeutic drug use
PHARMACOTHERAPEUTICS Mineral sources (anesthetics)
Study of drugs in tx & prevention of dse Semi-synthetic sources
pharmacodynamics + pharmacokinetics Synthetic sources STEPS IN DRUG DEVELOPMENT
CLINICAL PHARMACOLOGY Biosynthetic sources 1. Discovery or synthesis of a new
Study of the clinical pharmacological drug molecule and correlating it with a
evaluation of drugs in human use CLASSIFICATION OF DRUGS biological target
PHARMACOGENETICS/ 1. ORIGIN OR SOURCE: natural or 2. In vitro and animal studies to assess the
PHARMACOGENOMICS synthetic (70% of drugs) safety and efficacy of drugs
Study of genetic variation in response 2. CHEMICAL STRUCTURE: acids/bases 3. Human testing or clinical trials
to drug effects among individuals or 3. PHYSIOLOGIC USE: vitamins, lipid 4. Safety monitoring after approval for
population. lowering agents general use
PHARMACOVIGILANCE 4. THERAPEUTIC USE: best class
All scientific and data gathering activities 5. ANTI-PATHOGENS: antiviral, DEVELOPMENT PROCESS OF DRUGS
that relate to detection, assessment, anti-bacterial, antiparasitic, anti-
understanding and prevention of adverse chemotherapeutic
events 6. FUNCTION MODIFIERS: anti-HPN
PHARMACOECONOMICS 7. RESTORATIVES: replenish deficiencies
Study of economic use and management in the body
(treatment and prevention) of disease
Cost effectivity of drugs CLASSIFICATION OF DRUGS
TOXICOLOGY ACCDG TO GENERAL USE
Study of adverse effects of drugs 1. FUNCTIONAL MODIFIERS
Alters normal physiologic functions.
Withdrawals from the market as a result of Analgesics
spontaneous reporting Antipyretics fever response to PHASES OF CLINICAL TRIALS
presence of interleukin-1 (endopyrogen)
Anti-Inflammatories
blockers tachycardia, palpitations

2. REPLENISHERS
Supplement endogenous
substances that are lacking or deficient.
Insulin for Type 1DM
Water
Electrolyte Diarrhea
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