Dolly Madan Synopsis Lay Out

APPLICATION FOR REGISTRATION OF TITLE OF THESIS FOR
M.D.(PAEDIATRICS)EXAMINATION
1.a. Name of candidate : DR. DOLLY MADAN
b.Name of the course: M.D. (Pediatrics)
c.Year and month of registration: May 2017
d.Year and month of examination: April 2020
2.TITLE OF THE PROPOSED THESIS: Study of Lipid Profile during

chemotherapy in children with Acute Lymphoblastic Leukemia.
3. NAME AND DESIGNATION OF THE GUIDE:
Prof. VINEETA GUPTA
Head of Department
Department of Pediatrics,
Institute of medical sciences,
Banaras Hindu University,
Varanasi,
Uttar Pradesh,
India.
4. NAME AND DESIGNATION OF THE CO-GUIDE
Dr. Priyanka Agrawal
Department of Pediatrics
Institute of medical sciences,
Varanasi,
Uttar Pradesh,
India.
5.a. Department where thesis work wil be carried out: Department of

Paediatrics,
Institute of Medical Sciences,
Varanasi,
Uttar Pradesh,
India.
b.Which other departments of the institute will co- opertate in the

thesis work:
None
6. STATE BRIEFLY THE OBJECTIVES AND SCOPE OF THE PROPOSED
RESEARCH WORK
Acute Lymphoblastic Leukemia is the most common cancer of

childhood and is the first disseminated cancer shown to be curable. The
advent of chemotherapy has increased the survival rate dramatically.
However effective therapy can cause adverse interactions and
complications. Significant changes in lipid levels have been observed in
patients of ALL receiving chemotherapy. Hypertriglyceridemia also
correlates with pancreatitis in such patients. The study focuses on
evaluating the alterations in lipid levels in patient of ALL receiving
chemotherapy. Secondary outcomes of the study include correlation
of lipid levels with nutritional status , risk stratification , development of
pancreatitis and occurrence of thromboembolism and osteonecrosis.
7. LACUNAE IN THE KNOWLEDGE ON SUBJECT:
No similar study has been done on lipid profiles during ALL

chemotherapy in our country , although some studies are
available in western literature . So by this study we will be able to
comment on lipid levels in Indian children receiving
chemotherapy for ALL and also compare the results with studies
done world wide.
8. STATE THE PRELLIMINARY WORK YOU HAVE ALREADY DONE ON
THIS PROBLEM eg. Selection of subjects , standardization of methods
etc, giving results, if any:
A brief review of literature has been done.
Inclusion and Exclusion criteria has been decided
INCLUSION CRITERIA : Newly diagnosed
ALL patients in 2 to 14 years age group giving consent to

participate.
EXCLUSION CRITERIA : Previously diagnosed cases already receiving

chemotherapy, relapsed and refractory cases.
9.STATE BRIEFLY WHETHER ANY WORK PERTAINING TO THE

PROPOSED WORK HAS BEEN DONE IN THE DEPARTMENT EARLIER :
NO
10. BRIEF RESUME OF RELEVANT LITERATURES ON THE PROPOSED

PROBLEMS AND LIST OF IMPORTANT REFERENCES: I
In patients of ALL receiving chemotherapy significant changes in lipid
levels have been observed. Triglycerides , LDL , VLDL, Cholesterol, Apo B
100 ,Apo C2 levels have been observed to be increased. HDL and ApoA1
levels have been found to be decreased. These changes have been
attributed to altered nutritional status, altered lipid metabolism,
defective LDL receptors and L asparaginase specific interactions.
* Nelson Textbook of Pediatrics
* Bhojwani D et al. Severe Hypertriglyceridemia during therapy for

childhood Acute Lymphoblastic Leukemia
Eur J Cancer. 2014 october ;50(15):2685-
2694.doi:10.1016/j.ejca.2014.06.023
*Hasan JG et al. Lipid profil hypertriglyceridemia es in children with

Acute Lymphoblastic Leukemia on L- asparaginase therapy , The
Medical Journal of Basrah University, 2010
* Einollahi et al.Serum Lipid Profile Alterations in Acute Leukemia

Before and After Chemotherapy
Einollahi N1, Alizadeh Sh2, Dashti N*1, Nabatchian Fa1, Zare Bovani
M1, Abbasi S3, Mohamadian M4, Kashani Khatib Z2
Clinical laboratory sciences department, Allied Medical School, Tehran

University of Medical sciences, Tehran, Iran.
Hematology Department, Allied Medical School, Tehran University of

Medical sciences, Tehran, Iran.
*Steinherz PG. Transient, severe hyperlipidemia in patients with ALL

treated with Prednisone and Asparaginase . Cancer1994;74(12)3234-
9[PubMed:7982187
11. Details of procedures and methods proposed to be used in the
study:
A total of 75 newly diagnosed patients completing induction of

remission will be included in the study
Lipid levels including HDL, LDL, Triglycerides and Cholesterol will be

obtained in ALL patients at the time of diagnosis , at 1 month after
start of therapy and at 6 months .
Lipid level are measured by blood chemistry analyser machine in CCI

Lab of SS Hospital.
Serum amylase and lipase will be done at baseline and 1 month.
Similarly lipid levels are obtained for control group but only once.
A comparison is made amongst the levels obtained at baseline and at

1 month and 6 months.
Signature of the Guide Candidate- Dr Dolly Madan
Prof. Vineeta Gupta
Professor and Head of Department

Varanasi.
Signature of the HOD
Prof. Vineeta Gupta
Professor and H.O,D

Varanasi.

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APPLICATION FOR REGISTRATION OF TITLE OF THESIS FOR

1.a. Name of candidate : DR. DOLLY MADAN

b.Name of the course: M.D. (Pediatrics)

c.Year and month of registration: May 2017

d.Year and month of examination: April 2020

2.TITLE OF THE PROPOSED THESIS: Study of Lipid Profile during

3. NAME AND DESIGNATION OF THE GUIDE:

Prof. VINEETA GUPTA

Institute of medical sciences,

Banaras Hindu University,

Dr. Priyanka Agrawal

Institute of medical sciences,

Banaras Hindu University,

5.a. Department where thesis work wil be carried out: Department of

Institute of Medical Sciences,

Banaras Hindu University,

b.Which other departments of the institute will co- opertate in the

Acute Lymphoblastic Leukemia is the most common cancer of

7. LACUNAE IN THE KNOWLEDGE ON SUBJECT:

No similar study has been done on lipid profiles during ALL

A brief review of literature has been done.

Inclusion and Exclusion criteria has been decided

INCLUSION CRITERIA : Newly diagnosed

ALL patients in 2 to 14 years age group giving consent to

EXCLUSION CRITERIA : Previously diagnosed cases already receiving

9.STATE BRIEFLY WHETHER ANY WORK PERTAINING TO THE

10. BRIEF RESUME OF RELEVANT LITERATURES ON THE PROPOSED

* Nelson Textbook of Pediatrics

* Bhojwani D et al. Severe Hypertriglyceridemia during therapy for

*Hasan JG et al. Lipid profil hypertriglyceridemia es in children with

* Einollahi et al.Serum Lipid Profile Alterations in Acute Leukemia

Clinical laboratory sciences department, Allied Medical School, Tehran

Hematology Department, Allied Medical School, Tehran University of

*Steinherz PG. Transient, severe hyperlipidemia in patients with ALL

A total of 75 newly diagnosed patients completing induction of

Lipid levels including HDL, LDL, Triglycerides and Cholesterol will be

Lipid level are measured by blood chemistry analyser machine in CCI

Serum amylase and lipase will be done at baseline and 1 month.

A comparison is made amongst the levels obtained at baseline and at

Prof. Vineeta Gupta

Professor and Head of Department

Signature of the HOD

Prof. Vineeta Gupta

Professor and H.O,D

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