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    Neurofibromatosis in Pregnancy

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    Dwi Wahyu Apriani
    This case report describes a woman with neurofibromatosis (NF) who became pregnant. At 30 weeks, she was diagnosed with placenta praevia based on ultrasound. She later experienced bleeding and underwent a cesarean section at 38 weeks, delivering a baby boy. Lesions indicative of NF were noticed on the newborn three days after delivery, suggesting transmission from mother to child. NF is a genetic disorder that can increase obstetric risks like miscarriage and preterm delivery. While pregnancy outcomes for women with NF are often complicated, this case highlights the possibility of normal pregnancy and transmission of NF to the baby.

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    Neurofibromatosis in Pregnancy

    Uploaded by

    Dwi Wahyu Apriani
    142 views2 pages
    This case report describes a woman with neurofibromatosis (NF) who became pregnant. At 30 weeks, she was diagnosed with placenta praevia based on ultrasound. She later experienced bleeding and underwent a cesarean section at 38 weeks, delivering a baby boy. Lesions indicative of NF were noticed on the newborn three days after delivery, suggesting transmission from mother to child. NF is a genetic disorder that can increase obstetric risks like miscarriage and preterm delivery. While pregnancy outcomes for women with NF are often complicated, this case highlights the possibility of normal pregnancy and transmission of NF to the baby.

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    This case report describes a woman with neurofibromatosis (NF) who became pregnant. At 30 weeks, she was diagnosed with placenta praevia based on ultrasound. She later experienced bleeding and underwent a cesarean section at 38 weeks, delivering a baby boy. Lesions indicative of NF were noticed on the newborn three days after delivery, suggesting transmission from mother to child. NF is a genetic disorder that can increase obstetric risks like miscarriage and preterm delivery. While pregnancy outcomes for women with NF are often complicated, this case highlights the possibility of normal pregnancy and transmission of NF to the baby.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    142 views2 pages

    Neurofibromatosis in Pregnancy

    Uploaded by

    Dwi Wahyu Apriani
    This case report describes a woman with neurofibromatosis (NF) who became pregnant. At 30 weeks, she was diagnosed with placenta praevia based on ultrasound. She later experienced bleeding and underwent a cesarean section at 38 weeks, delivering a baby boy. Lesions indicative of NF were noticed on the newborn three days after delivery, suggesting transmission from mother to child. NF is a genetic disorder that can increase obstetric risks like miscarriage and preterm delivery. While pregnancy outcomes for women with NF are often complicated, this case highlights the possibility of normal pregnancy and transmission of NF to the baby.

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    IJAIMS

    10.5005/jp-journals-10050-10031
    Neurofibromatosis in Pregnancy: A Case Report
    Case Report

    Neurofibromatosis in Pregnancy
    1
    Sonika Dahiya, 2Shobha Mukherjee, 3HK Premi

    ABSTRACT ultrasonography (USG), placenta praevia was diagnosed


    Neurofibromatosis (NF) is one of the most frequent genetic and patient was managed conservatively at that time and
    diseases in humans. It is less common to find pregnancy in NF was put on Mcafee Johnson regimen. Skin lesions were
    patients. It may not reflect the real situation as most current noticed all over the body, and the patient had history of
    information on pregnancy and NF is derived from case reports. development of nodular lesions on her body since the age
    In the past 15 years only two series of pregnant NF patients
    were reported in English language literature. of 5 years (Figs 1A and B). With age, these have gradu-
    Neurofibromatosis is a genetic disorder which increases ally increased in number and size. Skin reference was
    the risk of obstetric complications as well as aggravation of done and the patient was diagnosed as a case of NF and
    maternal disease. However, here is a case of NF in which discharged under satisfactory condition after 2 weeks
    transmission to baby has also occurred, which is very rare.
    of hospitalization, with the advice to report to hospital
    Keywords: Neurofibromatosis, Obstetric complications, immediately if she has any bleeding p/v. After that, the
    Pregnancy.
    patient was presented in obstetrics ward with complaint of
    How to cite this article: Dahiya S, Mukherjee S, Premi HK. bleeding p/v at 38 weeks of gestation. A repeat USG was
    Neurofibromatosis in Pregnancy. Int J Adv Integ Med Sci 2016; done, and in view of placenta praevia, her lower segment
    1(2):91-92.
    cesarian section was done and a male baby, weighing 3 kg,
    Source of support: Nil was delivered. Neurofibromatosis lesions were noticed on
    Conflict of interest: None the newborn on the 3rd day of delivery (Fig. 2).

    INTRODUCTION
    Neurofibromatosis (NF) is a distinct genetic disorder
    with a multitude of clinical manifestations. Its incidence
    in pregnancy varies from 1/5,000 to 1/18,500 deliveries.1
    Most of the current obstetric literature indicates that preg-
    nant women with NF type 1 (NF1) have increased risk
    of complications like spontaneous miscarriage, preterm
    delivery, preeclampsia, intrauterine growth restriction,
    stillbirths, and maternal disease aggravation.
    The present case study describes a case of NF in
    pregnancy in Rohilkhand Medical College and Hospital,
    Bareilly, Uttar Pradesh, India, in which transmission to
    A
    baby also occurred at postoperative day 3.

    CASE REPORT
    A 28-year-old Gravida 3, Para 2, Live 1 woman, who had
    been married for 8 years, came to OPD at 30 weeks of ges-
    tation with a complaint of bleeding per vaginum (p/v). On

    1
    Postgraduate Student, 2Associate Professor, 3Professor and
    Head
    1-3
    Department of Obstetrics and Gynecology, Rohilkhand
    Medical College and Hospital, Bareilly, Uttar Pradesh, India
    Corresponding Author: Sonika Dahiya, Postgraduate Student
    Department of Obstetrics and Gynecology, Rohilkhand Medical B
    College and Hospital, Bareilly, Uttar Pradesh, India, Phone:
    +919458625746, e-mail: sonika1905@gmail.com Figs 1A and B: Neurofibromatosis lesions on the back and
    abdomen of the patient

    International Journal of Advanced & Integrated Medical Sciences, April-June 2016;1(2):91-92 91


    Sonika Dahiya et al

    a result of spontaneous mutations or could be inherited


    from the parents. The management of these women with
    NF during pregnancy remains controversial, as some
    authors recommend early termination of pregnancy in
    view of the pregnancy complications, listed earlier, and
    possible transmission to the fetus. But then, there are
    others, who suggest that there may not be associated
    significant obstetric complications and therefore may
    have a normal pregnancy outcome.
    The present case bears testimony to the later view.
    An increased rate of cesarean section is also reported,
    which could be due to fetal distress, malpresentation and
    cephalopelvic disproportion due to undiagnosed pelvic
    NF and pelvic contractures, including cases of kypho-
    Fig. 2: Neurofibromatosis lesions on the newborn
    scoliosis, affecting the lower spine (sequelae of NF1).2

    DISCUSSION REFERENCES

    Neurofibromatosis is an autosomal dominant condition, 1. Oh YM, Koh MS, Yeu JE, Park CS, Cho SJ. A case report of
    vertebral artery aneurysm and preeclampsia complicating a
    which includes the more common NF1 caused by muta-
    pregnancy with neurofibromatosis. Korean J Obstet Gynecol
    tion in NF1 tumor suppressor gene on chromosome 17 2000 Jun;43(6):1114-1118.
    and less frequent NF2 caused by mutation in NF2 gene 2. Dugoff L, Sujansky E. Neurofibromatosis type 1 and preg-
    on chromosome 22. The condition could occur de novo as nancy. Am J Med Genet 1996 Dec 2;66(1):7-10.

    92

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