Kabiven: (Amino Acids, Electrolytes, Dextrose and Lipid Injectable Emulsion), For Intravenous Use
Kabiven: (Amino Acids, Electrolytes, Dextrose and Lipid Injectable Emulsion), For Intravenous Use
Kabiven: (Amino Acids, Electrolytes, Dextrose and Lipid Injectable Emulsion), For Intravenous Use
KABIVEN®
(amino acids, electrolytes, dextrose and lipid
injectable emulsion), for intravenous use
--------------------------DRUG INTERACTIONS-------------------------
Coumarin and coumarin derivatives, including warfarin:
Anticoagulant activity may be counteracted; monitor laboratory
parameters. (7.1)
Revised: 10/2016
Limitations of Use:
KABIVEN® is not recommended for use in pediatric patients
under the age of 2 years, including preterm infants because the
fixed content of the formulation does not meet the nutritional
requirements of this age group [see Warnings and Precautions
(5.1) and Use in Specific Populations (8.4)].
1. Overpouch Notch
2. Handle
3. Hole (For hanging the bag)
4. Vertical Seals (Must break to activate)
5. Bends in Vertical Seals
6. Horizontal Seal (May remain unopened)
7. Blind Port (NEVER use this port)
8. WHITE Additive Port
9. BLUE Infusion Port
10. Oxygen Absorber (Present between bag and inside
overpouch-position may vary)
An instructional video is available at www.KabivenUSA.com.
2c 2. REMOVE OVERPOUCH.
a) Place bag on a clean, flat surface.
b) Tear from Overpouch Notch,
located close to the ports.
c) Tear long sides open to access the
inner bag.
d) Discard Overpouch and Oxygen
Absorber.
3. ACTIVATE BAG.
3a a) Place bag on a clean, flat surface
with text side up and ports
pointing away from you.
b) Roll tightly from top of bag down
toward ports.
c) Apply pressure until both Vertical
Seals break and entire contents are
white. It may take up to 5 seconds
of continued pressure to break
Vertical Seals.
NOTE: Both Vertical Seals must
3b
be broken from bends to ports.
Upper section of Vertical Seals
and Horizontal Seal may remain
unbroken.
d) After both Vertical Seals are
broken, mix contents thoroughly
by inverting the bag at least three
times to ensure a homogenous
mixture.
7 DRUG INTERACTIONS
7.1 Coumarin and Coumarin Derivatives
The soybean oil present in KABIVEN® has vitamin K1. Vitamin K1
can reverse the anticoagulant activity of coumarin and coumarin
derivatives, including warfarin, which work by blocking recycling
of vitamin K1. Monitor laboratory parameters for anticoagulant
activity in patients who are on both KABIVEN® and coumarin or
coumarin derivatives.
HO
OH OH•H2O
HO
OH
Electrolytes
Sodium Acetate Trihydrate,
USP CH3COONax3H2O
Potassium Chloride, USP KCl
Sodium Glycerophosphate C3H5(OH)2PO4Na2xH2O
Magnesium Sulfate
Heptahydrate, USP MgSO4x7H2O
Calcium Chloride Dihydrate, USP CaCl2x2H2O
Essential Amino Acids
Lysine (added as the H2N(CH2)4CH(NH2)COOH.HCl
hydrochloride salt)
Phenylalanine CH2CH(NH2)COOH
Leucine (CH3)2CHCH2CH(NH2)COOH
Valine (CH3)2CHCH(NH2)COOH
Threonine CH3CH(OH)CH(NH2)COOH
Methionine CH3S(CH2)2CH(NH2)COOH
Isoleucine CH3CH2CH(CH3)CH(NH2)COOH
H
N
Tryptophan CH2CH(NH2)COOH
where R1C‑, R2C‑ and R3C‑ are saturated and unsaturated fatty
acid residues. The major component fatty acids are linoleic (48 to
58 %), oleic (17 to 30%), palmitic (9 to 13%), linolenic (5 to 11%) and
stearic acid (2.5 to 5%).
These fatty acids have the following chemical and structural
formulas:
0
H2 H2 H H H H H2 H2 H2
Linoleic acid C C C C C C C C C C OH
/\ ⁄ \ / \ / \ /\ /\ /\ /
C18H32O2
H3C C C C
C C C C
H2 H2 H2
H2 H2 H2 H2
0
H2 H2 H2 H H H2 H2 H2
Oleic acid H3C C C C C C C C C C OH
\/\ ⁄ \ /\ / \ / \ /\ /\ /
C18H34O2 C C C C C C C C
H2 H2 H2 H2 H2 H2 H2 H2
0
H2 H2 H2 H2 H2 H2 H2
Palmitic acid C C C C C C C C OH
/\ ⁄ \ / \ / \ /\ /\ /\ /
C16H32O2 H3C C C C C C C C
H2 H2 H2 H2 H2 H2 H2
0
H H H H H H H2 H2 H2
Linolenic acid H3C C C C C C C C C C C OH
\ / \ ⁄ \ / \ / \ /\ /\ /
C18H30O2 C C C
C C C C
H2 H2 H2
H2 H2 H2 H2
0
H2 H2 H2 H2 H2 H2 H2 H2
Stearic acid C C C C C C C C C OH
/\ ⁄ \ / \ / \ /\ /\ /\ /\ /
C18H36O2 H3C C C C C C C C C
H2 H2 H2 H2 H2 H2 H2 H2
Uppsala, Sweden
www.fresenius-kabi.us 451206C