Hiertensi
Hiertensi
Hiertensi
I. Background
Along with the many problems in adherence to taking medication in hypertensive patients,
making efficacy of antihypertensive treatment in preventing cardiovascular complications is
hampered. The aim of this study was to examine medication adherence and its relationship to
blood pressure control (BP), cardiovascular disease (CVD) hospitalization, and all causes of
hospitalization.
II. Method
Medical and pharmaceutical claims were obtained from the Taiwan National Health Insurance
(NHI) database. To determine the level of adherence to taking medication, we calculated the
proportion of closed days (PDC) by filling a prescription. Treatment association with BP control,
CVD hospitalization, and all hospital care were examined using several logistic regression
models.
III. Result
The subjects studied were 29,685 hypertensive patients. Of the total, 40.1% of patients had a
hypertensive history of more than 5 years and 39.7% of patients had multiple comorbidities.
Overall, 85.5% of patients were categorized as adherent, with PDC more than equal to 80; 60%
of adherent patients have good BP control. Poor treatment adherence was associated with poor
BP control (odds ratio (OR) = 1.20, 1.13-1.29), CVD hospitalization (OR = 1.43, 1.14-1.81), and
all causes of hospitalization (OR = 1.47, 1.21-1.78).
IV. Conclusion
From the observational studies we have done clearly show that lower medication adherence is
associated with poor BP control and higher CVD risk and all causes of hospitalization in
hypertensive patients.
The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and
Treatment of High Blood Pressure identifies the main cause for poor control of BP is poor adherence
to treatment. In addition to so low treatment rates, low levels of BP control illustrate poor adherence
to treatment. With the limited data that is available from the National Taiwan Health Insurance
program (NHI) and electronic records of disease management programs, a retrospective cohort of
patients was observed to investigate medication adherence and its relationship to BP control, CVD
hospitalization, and all-cause hospitalization.
METHODS
The mandatory NHI system has been implemented in Taiwan since 1995. This system requires all
claims, including outpatient, inpatient and pharmaceutical claims, to be submitted electronically.
Compliance with taking medication. To determine the level of medication adherence, the proportion
of closed days (PDC) was calculated by filling the prescription, which was measured as the number
of days given with the prescribed filled divided by the total day of each patient's observation period.
RESULTS
Univariate analysis of predictors for poor BP control, CVD hospitalization, and all causes of
hospitalization. Adherence levels, male gender, current smoking, current drinking, obesity,
hyperlipidemia, history of hypertension, Charlson's comorbidity index, and number of drugs were
potential predictors of poor BP control. Adherence, age, history of hypertension over 5 years,
Charlson comorbidity index, and number of drugs were potential predictors of CVD and all causes
of hospitalization.
DISCUSSION
Only from a number of observational studies have shown that medication adherence benefits are
related to reduced mortality or risk of hospitalization for hypertensive patients. Termination of the
use of antihypertensive drugs is associated with an increased risk of coronary heart disease. All the
risks of hospitalization in reality are lower in obedient patients, compared to patients who are not
adherent. The latest, high adherence to antihypertensive drugs has been found to reduce the risk of
cerebrovascular disease in the context of real practice.