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    Agri-Varisty - Scientistsdiscover A New Cure

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    Hikmat Ullah
    Parturient hemoglobinuria is a metabolic disease affecting high-yielding pregnant buffaloes and cows in Pakistan and other countries. It causes hemoglobin in the urine (hemoglobinuria), anemia, and can be fatal. Standard treatment uses sodium dihydrogen phosphate, but has variable results and side effects. Researchers in Pakistan tested a new antioxidant therapy using intravenous and oral N-acetylcysteine and vitamin C. In an initial study of 25 animals, 23 recovered with this treatment, which took only 2 days and had no discernable side effects. While more research is needed, results so far are encouraging compared to standard therapy.

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    Agri-Varisty - Scientistsdiscover A New Cure

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    Hikmat Ullah
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    Parturient hemoglobinuria is a metabolic disease affecting high-yielding pregnant buffaloes and cows in Pakistan and other countries. It causes hemoglobin in the urine (hemoglobinuria), anemia, and can be fatal. Standard treatment uses sodium dihydrogen phosphate, but has variable results and side effects. Researchers in Pakistan tested a new antioxidant therapy using intravenous and oral N-acetylcysteine and vitamin C. In an initial study of 25 animals, 23 recovered with this treatment, which took only 2 days and had no discernable side effects. While more research is needed, results so far are encouraging compared to standard therapy.

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    Parturient hemoglobinuria is a metabolic disease affecting high-yielding pregnant buffaloes and cows in Pakistan and other countries. It causes hemoglobin in the urine (hemoglobinuria), anemia, and can be fatal. Standard treatment uses sodium dihydrogen phosphate, but has variable results and side effects. Researchers in Pakistan tested a new antioxidant therapy using intravenous and oral N-acetylcysteine and vitamin C. In an initial study of 25 animals, 23 recovered with this treatment, which took only 2 days and had no discernable side effects. While more research is needed, results so far are encouraging compared to standard therapy.

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    27 views2 pages

    Agri-Varisty - Scientistsdiscover A New Cure

    Uploaded by

    Hikmat Ullah
    Parturient hemoglobinuria is a metabolic disease affecting high-yielding pregnant buffaloes and cows in Pakistan and other countries. It causes hemoglobin in the urine (hemoglobinuria), anemia, and can be fatal. Standard treatment uses sodium dihydrogen phosphate, but has variable results and side effects. Researchers in Pakistan tested a new antioxidant therapy using intravenous and oral N-acetylcysteine and vitamin C. In an initial study of 25 animals, 23 recovered with this treatment, which took only 2 days and had no discernable side effects. While more research is needed, results so far are encouraging compared to standard therapy.

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    © All Rights Reserved
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    Discovery of a new cure for parturient hemoglobinuria in buffaloes and cows

    Prof. (R) Dr. Ghulam Muhammad, Dr. M. Saqib, and Dr. Imaad Rashid
    Department of Clinical Medicine and Surgery, University of Agriculture, Faisalabad, 38040
    – Pakistan
    Parturient hemoglobinuria (red water; colloquially known as Rut Mootra) is one of the
    major and economically important metabolic diseases of dairy animals in Pakistan, India,
    Egypt and elsewhere in the world. It is an acute disease of high yielding/pregnant buffaloes
    and cows characterized by hypophosphatemia, intravascular hemolysis, hemoglobinuria
    (reddish urine), anemia and death. Buffaloes in advanced pregnancy or within first few
    months of calving are particularly susceptible. The disease is far more common in buffaloes
    than in cows. In a survey conducted during 1996 in Punjab (Pakistan), 9% mortality due to
    hemoglobinuria in buffaloes was reported which translated into estimated annual losses of
    Rs. 490.0 millions. Given a steep escalation of prices of dairy animals over the past 19
    years, the magnitude of current pecuniary losses associated with this disease may run into
    several billion rupees annually in Pakistan.

    Standard treatment of parturient hemoglobinuria is based on parenteral and oral


    administration of sodium dihydrogen phosphate (NaH2PO4), popularly known as sodium
    acid phosphate. Response to sodium acid phosphate therapy can be described as variable at
    best and cure rate almost never exceeds 50%. Another flip side of the sodium acid
    phosphate therapy is that treated animals become off feed and thus sustain a considerable
    loss of body weight and milk yield. It follows that an alternative effective treatment without
    these side effects is warranted.

    Taking cues from observation of Indian investigators (Chugh S.K., R.M. Bhardwaj and
    M.M. Mata, 1998. Lowered antioxidant status of red blood cells in post-parturient
    hemoglobinuria of buffaloes. Vet. Res. Communication., 22: 385-388) that there is a
    significant decrease in antioxidant status in parturient hemoglobinuria affected animals, we
    recently tested the efficacy of an antioxidant therapy in the treatment of this disease. This de
    novo therapy is based on intravenous administration of 2.4 to 4g of N-acetylcysteine in 1
    liter of 5% dextrose followed by a similar dose per os 12 hours later. Ten grams of vitamin
    C is also administered orally on daily basis. Of the 25 cows ad buffaloes treated thus far
    with this regimen, 23 animals recovered and survived. In 2 animals, urine color returned to
    normal but death ensued as the animals were recruited for treatment at an advanced stage of
    the disease. A 2 days therapy with acetylcysteine + vitamin C generally suffices. This new
    treatment is bereft of any discernable untoward effect and considerably less costly than the
    standard treatment given ut supra. At the moment, results though seemingly encouraging
    and much better than those with standard therapy should be construed as preliminary only
    and lack the backing of carefully controlled scientific trials. As far as could be ascertained,
    the use of acetylcysteine (a potent antidoxidant) has not as yet been evaluated in the
    treatment of parturient hemoglobinuria in cow and buffaloes anywhere in the world. The
    investigations conducted thus far were in a private capacity. Investigations aimed at
    determining the mechanistic specificity of N-acetylcysteine through carefully controlled
    clinical trial in hemoglobinuria and other oxidative stress associated clinical disorders of
    animals are in the offing.

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