New Drugs 2019

Dr. Ranjan Kumar Patel

New Drug Mechanism of Action Use
Esketamine nasal NMDA antagonist Resistant depression
spray
Netarsudil + Netarsudil is a rho kinase inhibitor Open angle glaucoma
Latanoprost FDC and latanoprost is a prostaglandin
ophthalmic F2alpha analog
solution
Trastuzumab + Hyaluronidase increases Her2 positive breast cancer
Hyaluronidase absorption rate of trastuzumab
FDC
Triclabendazole Benzimidazole which inhibits Liver flukes
microtubules
Caplacizumab Anti von Willebrand factor Acquired
monoclonal antibody which blocks thrombocytopenic purpura
adhesion of platelets to blood
vessels
Parabotulinum Inhibits release of acetylcholine Temporary improvement
toxin A in glabellar lines associated
with corrugator and/or
procerus muscle activity in
adults
Brexanolone GABA-A receptor modulator Postpartum depression
Tafamidis Oral transthyretin stabilizer Cardiomyopathy of wild
meglumine type or hereditary
transthyretin-mediated
amyloidosis (ATTR-CM)
Risankizumab Anti IL-23 monoclonal antibody Plaque psoriasis
Onasemnogene Adeno-associated virus vector- Spinal muscular atrophy
abeparvovec based gene therapy (SMA) in children < 2 years

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 New Drugs 2019
Dr. Ranjan Kumar Patel
Polatuzumab Immunotoxin made up of Used along with
vedotin polatuzumab (anti CD 79b MAb) bendamustine and
and vedotin (toxin) rituximab for treatment of
diffuse large B cell
lymphoma
Venetoclax and Venetoclax is a BCL-2 inhibitor and Chronic lymphocytic
Obinutuzumab Obinutuzumab is an anti CD 20 leukemia and small
FDC monoclonal antibody lymphocytic lymphoma
Ramucirumab Anti VEGFR monoclonal antibody Hepatocellular carcinoma
in patients having alpha
feto protein levels > 400
ng/ml, despite being
treated with sorafenib
Amifampridine Potassium channel blocker Lambert Eaton myasthenic
syndrome in patients of 6-
17 years age
Dengvaxia Recombinant live tetravalent Prevention of dengue
dengue vaccine caused by serotypes 1-4
only in age group 9-16
years with laboratory
confirmed previous dengue
infection
Ruxilotinib JAK 1 and 2 inhibitor Treatment of steroid
resistant acute GVHD in
age group more than 12
years
Certolizumab Anti TNF alpha drug Treatment of active non-
radiographic axial
spondylarthritis with
objective signs of
inflammation

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 New Drugs 2019
Dr. Ranjan Kumar Patel
Romosozumab Antisclerostin monoclonal antibody Osteoporosis in
postmenopausal females
with high risk of fracture
Cladribine Purine analog Relapsing form of multiple
sclerosis
Siponimod Sphingosine 1-phosphate receptor Relapsing form of multiple
modulator sclerosis
Avelumab plus Avelumab is an anti-programmed Combination therapy has
Axitinib death ligand 1 monoclonal been approved for
antibody and axitinib is a VEGFR treatment of renal cell
tyrosine kinase inhibitor carcinoma
Pembrolizumab Pembrolizumab is an anti- Renal cell carcinoma
programmed death ligand 1 Advanced endometrial
receptor monoclonal antibody carcinoma
Squamous cell cancer of
esophagus
Small and non-small cell
lung cancer

Intranasal GABA A receptor agonist Acute repetitive seizures in

midazolam spray age group > 12 years of age
Solriamfetol Dopamine and norepinephrine Excessive sleepiness
reuptake inhibitor associated with narcolepsy
and obstructive sleep
apnea
Alpelisib Phosphatidyl inositol 3 kinase Treatment of ER+ breast
(PI3K) inhibitor cancer in postmenopausal
females with PI3KCA
mutation in combination
with fluvestrant

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 New Drugs 2019
Dr. Ranjan Kumar Patel
Atezolizumab Anti-programmed death cell ligand Used along with paclitaxel
1 monoclonal antibody for treatment of triple
negative breast cancer
which is unresectable or
locally advanced
Erdafitinib Fibroblast growth factor receptor Locally advanced or
tyrosine kinase inhibitor metastatic urothelial
carcinoma
Apremilast Phosphodiesterase-4 inhibitor Oral ulcers associated with
Bechet’s syndrome
Oral semaglutide It is the first oral GLP-1 agonist. It is Type II diabetes mellitus
to be taken exactly 30 minutes
before the first food of the day.
Sodium caprylate is added to
semaglutide to increase its
intestinal absorption.
Tenapanor Sodium/hydrogen exchanger 3 IBS associated with
(NHE3) inhibitor. constipation
NHE3 is an antiporter that absorbs
sodium in the intestine in exchange
for proton. Hence its inhibition
increases sodium in intestine, that
draws water.
Relebactam Beta lactamase inhibitor Approved to be used with
imipenem + cilastatin for
treatment of complicated
UTI and intraabdominal
infections
Fedratinib Oral Janus Associated Kinase 2 Myelofibrosis
(JAK2) and FMS-like tyrosine kinase
3 (FLT3) inhibitor

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 New Drugs 2019
Dr. Ranjan Kumar Patel
Selinexor Nuclear export inhibitor Resistant multiple
By inhibition of export of tumor myeloma
suppressor proteins from nucleus
of cancer cells, it induces apoptosis
of cancer cells.
Nintedanib Multiple tyrosine kinase inhibitor Systemic sclerosis
associated interstitial lung
disease
Pretomanid Mycolic acid synthesis inhibitor Approved for treatment of
XDR TB along with
bedaquiline and linezolid
Lefamulin Protein synthesis inhibitor which Community acquired
acts by inhibiting peptidyl pneumonia
transferase
Upadacitinib Oral JAK inhibitor Methotrexate resistant
rheumatoid arthritis
Ixekizumab Anti-IL17A monoclonal antibody Active ankylosing
spondylitis
Pitolisant Histamine-3 (H3) receptor Narcolepsy
antagonist/inverse agonist
Istradefylline Adenosine A2A receptor antagonist On-off phenomena seen
with levodopa
Bremelanotide Melanocortin peptide receptors Hypoactive sexual desire
agonist disorder in premenopausal
females
Darolutamide Androgen receptor inhibitor Non-metastatic castration
resistant prostate cancer
Entrectinib Multiple kinase (RTL, ROS1, ALK) ROS1 positive metastatic
inhibitor non-small cell lung cancer

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 New Drugs 2019
Dr. Ranjan Kumar Patel
Pexidartinib Multi-kinase inhibitor Symptomatic tenosynovial
giant cell tumor

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